Impact of cerebral blood flow and amyloid load on SUVR bias.
Alzheimer’s disease
Amyloid PET
Cerebral blood flow
Quantification
SUVR bias
Journal
EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946
Informations de publication
Date de publication:
12 May 2022
12 May 2022
Historique:
received:
14
01
2022
accepted:
25
04
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
14
5
2022
Statut:
epublish
Résumé
Despite its widespread use, the semi-quantitative standardized uptake value ratio (SUVR) may be biased compared with the distribution volume ratio (DVR). This bias may be partially explained by changes in cerebral blood flow (CBF) and is likely to be also dependent on the extent of the underlying amyloid-β (Aβ) burden. This study aimed to compare SUVR with DVR and to evaluate the effects of underlying Aβ burden and CBF on bias in SUVR in mainly cognitively unimpaired participants. Participants were scanned according to a dual-time window protocol, with either [ Despite high correlations (GCA: R The present findings demonstrate that bias in SUVR relative to DVR is strongly related to underlying Aβ burden. Furthermore, in a cohort consisting mainly of cognitively unimpaired individuals, the effect of relative CBF on bias in SUVR appears limited. EudraCT Number: 2018-002277-22, registered on: 25-06-2018.
Sections du résumé
BACKGROUND
BACKGROUND
Despite its widespread use, the semi-quantitative standardized uptake value ratio (SUVR) may be biased compared with the distribution volume ratio (DVR). This bias may be partially explained by changes in cerebral blood flow (CBF) and is likely to be also dependent on the extent of the underlying amyloid-β (Aβ) burden. This study aimed to compare SUVR with DVR and to evaluate the effects of underlying Aβ burden and CBF on bias in SUVR in mainly cognitively unimpaired participants. Participants were scanned according to a dual-time window protocol, with either [
RESULTS
RESULTS
Despite high correlations (GCA: R
CONCLUSION
CONCLUSIONS
The present findings demonstrate that bias in SUVR relative to DVR is strongly related to underlying Aβ burden. Furthermore, in a cohort consisting mainly of cognitively unimpaired individuals, the effect of relative CBF on bias in SUVR appears limited. EudraCT Number: 2018-002277-22, registered on: 25-06-2018.
Identifiants
pubmed: 35553267
doi: 10.1186/s13550-022-00898-8
pii: 10.1186/s13550-022-00898-8
pmc: PMC9098761
doi:
Types de publication
Journal Article
Langues
eng
Pagination
29Subventions
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : RYC-2013-13054
Organisme : Innovative Medicines Initiative
ID : 115372
Organisme : Innovative Medicines Initiative
ID : 115952
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 320030_169876
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 320030_185028
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : IZSEZ0_188355
Organisme : Velux Stiftung
ID : 1123
Informations de copyright
© 2022. The Author(s).
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