Maternal vitamin D status in pregnancy and molar incisor hypomineralisation and hypomineralised second primary molars in the offspring at 7-9 years of age: a longitudinal study.
Dental caries
Enamel hypomineralisation
HSPM
MIH
Pregnancy
Vitamin D
Journal
European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
ISSN: 1996-9805
Titre abrégé: Eur Arch Paediatr Dent
Pays: England
ID NLM: 101277157
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
21
12
2021
accepted:
12
04
2022
pubmed:
14
5
2022
medline:
3
8
2022
entrez:
13
5
2022
Statut:
ppublish
Résumé
The study aimed to investigate associations between maternal vitamin D status during pregnancy and molar incisor hypomineralisation (MIH) and hypomineralised second primary molars (HSPM) among children. The study had a longitudinal design using prospectively collected data from 176 mother and child pairs. Mothers were initially recruited in a randomised controlled trial to assess a pregnancy exercise programme. Along with the 7-year follow-up, we invited the children to a dental examination. The exposure variable was maternal serum 25-hydroxyvitamin D in gestational weeks 18-22 and 32-36, categorised as insufficient (< 50 nmol/l) and sufficient (≥ 50 nmol/l). Negative binomial hurdle models were used to analyse potential associations between the exposure variables and MIH or HSPM. The models were adjusted for potential confounders. Among the children (7-9 years old), 32% and 22% had at least one tooth with MIH or HSPM, respectively. A significant association was found between insufficient maternal vitamin D measured in gestational weeks 18-22 and the number of affected teeth among those with MIH at 7-9 years (adjusted RR = 1.82, 95% CI 1.13-2.93). Considering any limitations of the present study, it has been shown that insufficient maternal serum vitamin D at mid-pregnancy was associated with a higher number of affected teeth among the offspring with MIH at 7-9 years of age. Further prospective studies are needed to investigate whether this finding is replicable and to clarify the role of maternal vitamin D status during pregnancy and MIH, as well as HSPM, in children.
Identifiants
pubmed: 35553398
doi: 10.1007/s40368-022-00712-y
pii: 10.1007/s40368-022-00712-y
pmc: PMC9338139
doi:
Substances chimiques
Vitamin D
1406-16-2
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
557-566Subventions
Organisme : Fysiofondet
ID : 7/370-00/05
Organisme : Samarbeidsorganet
ID : 2006/9264-95
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022. The Author(s).
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