What Causes Desmoplastic Reaction in Small Intestinal Neuroendocrine Neoplasms?
Desmoplasia
Fibrosis
Growth factors
Small intestinal neuroendocrine tumours
Tumour microenvironment
Journal
Current oncology reports
ISSN: 1534-6269
Titre abrégé: Curr Oncol Rep
Pays: United States
ID NLM: 100888967
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
accepted:
04
10
2021
pubmed:
14
5
2022
medline:
17
9
2022
entrez:
13
5
2022
Statut:
ppublish
Résumé
Mesenteric desmoplasia in small intestinal neuroendocrine neoplasms (SINENs) is associated with increased morbidity and mortality. In this paper, we discuss the development of desmoplasia in SINENs. The fibrotic reactions associated with these tumours could be limited to the loco-regional environment of the tumour and/or at distant sites. Mesenteric fibrotic mass forms around a local lymph node. Formation of desmoplasia is mediated by interactions between the neoplastic cells and its microenvironment via number of profibrotic mediators and signalling pathways. Profibrotic molecules that are mainly involved in the desmoplastic reaction include serotonin, TGFβ (transforming growth factor β) and CTGF (connective tissue growth factor), although there is some evidence to suggest that there are a number of other molecules involved in this process. Desmoplasia is a result of autocrine and paracrine effects of multiple molecules and signalling pathways. However, more research is needed to understand these mechanisms and to develop targeted therapy to minimise desmoplasia.
Identifiants
pubmed: 35554845
doi: 10.1007/s11912-022-01211-5
pii: 10.1007/s11912-022-01211-5
pmc: PMC9474437
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1281-1286Informations de copyright
© 2022. The Author(s).
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