Versatile magnetic microdiscs for the radio enhancement and mechanical disruption of glioblastoma cancer cells.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
24 Feb 2020
24 Feb 2020
Historique:
received:
07
01
2020
accepted:
06
02
2020
entrez:
13
5
2022
pubmed:
25
2
2020
medline:
25
2
2020
Statut:
epublish
Résumé
This study describes the use of highly versatile, lithographically defined magnetic microdiscs. Gold covered magnetic microdiscs are used in both radiosensitizing cancer cells, acting as intracellular emitters of secondary electrons during radiotherapy, and as well as inducing mechanical damage by exerting a mechanical torque when exposed to a rotating magnetic field. This study reveals that lithographically defined microdiscs with a uniform size of 2 microns in diameter highly increase the DNA damage and reduce the glioblastoma colony formation potential compared to conventional radiation therapy. Furthermore, the addition of mechanical disruption mediated by the magnetic component of the discs increased the efficiency of brain cancer cell killing.
Identifiants
pubmed: 35558340
doi: 10.1039/d0ra00164c
pii: d0ra00164c
pmc: PMC9092955
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8161-8171Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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