Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
20 Dec 2019
20 Dec 2019
Historique:
received:
04
10
2019
accepted:
14
12
2019
entrez:
13
5
2022
pubmed:
2
1
2020
medline:
2
1
2020
Statut:
epublish
Résumé
Protein kinases are crucial drug targets in cancer therapy. Kinase inhibitors are promiscuous in nature due to the highly conserved nature of the kinase ATP binding pockets. PERK has emerged as a potential therapeutic target in cancer. However, PERK inhibitors GSK2606414 and GSK2656157 also target RIPK1 whereas AMG44 is more specific to PERK. To understand the structural basis for the selectivity of PERK ligands to RIPK1 we have undertaken a detailed
Identifiants
pubmed: 35558862
doi: 10.1039/c9ra08047c
pii: c9ra08047c
pmc: PMC9092956
doi:
Types de publication
Journal Article
Langues
eng
Pagination
367-375Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
A. M. G., A. S. and L. A. E. are co-founders of Cell Stress Discoveries, Ltd. The authors declare no conflicting interests.
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