Blood B Cell Depletion Reflects Immunosuppression Induced by Live-Attenuated Infectious Bursal Disease Vaccines.
B cells
IBDV
immunosuppression
live-attenuated vaccine
replication
vaccine safety
Journal
Frontiers in veterinary science
ISSN: 2297-1769
Titre abrégé: Front Vet Sci
Pays: Switzerland
ID NLM: 101666658
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
02
2022
accepted:
08
03
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
14
5
2022
Statut:
epublish
Résumé
Immunosuppression in poultry production is a recurrent problem worldwide, and one of the major viral immunosuppressive agents is Infectious Bursal Disease Virus (IBDV). IBDV infections are mostly controlled by using live-attenuated vaccines. Live-attenuated Infectious Bursal Disease (IBD) vaccine candidates are classified as "mild," "intermediate," "intermediate-plus" or "hot" based on their residual immunosuppressive properties. The immunosuppression protocol described by the European Pharmacopoeia (Ph. Eur.) uses a lethal Newcastle Disease Virus (NDV) infectious challenge to measure the interference of a given IBDV vaccine candidate on NDV vaccine immune response. A Ph. Eur.-derived protocol was thus implemented to quantify immunosuppression induced by one mild, two intermediate, and four intermediate-plus live-attenuated IBD vaccines as well as a pathogenic viral strain. This protocol confirmed the respective immunosuppressive properties of those vaccines and virus. In the search for a more ethical alternative to Ph. Eur.-based protocols, two strategies were explored. First,
Identifiants
pubmed: 35558891
doi: 10.3389/fvets.2022.871549
pmc: PMC9087897
doi:
Types de publication
Journal Article
Langues
eng
Pagination
871549Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2022 Courtillon, Allée, Amelot, Keita, Bougeard, Härtle, Rouby, Eterradossi and Soubies.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Avian Dis. 1999 Jul-Sep;43(3):401-13
pubmed: 10494408
J Gen Virol. 2019 Jan;100(1):5-6
pubmed: 30484762
Immunology. 2006 Apr;117(4):558-65
pubmed: 16556270
Avian Dis. 2018 Sep;62(3):272-285
pubmed: 30339511
Arch Virol. 1997;142(2):255-70
pubmed: 9125042
Viruses. 2021 Jan 14;13(1):
pubmed: 33466596
Dev Biol Stand. 1992;79:147-52
pubmed: 1337527
Front Microbiol. 2021 Jun 11;12:678563
pubmed: 34177862
Vet Immunol Immunopathol. 2012 Jan 15;145(1-2):86-99
pubmed: 22088676
Clin Chim Acta. 2008 Feb;388(1-2):130-4
pubmed: 18023278
Avian Pathol. 2018 Apr;47(2):179-188
pubmed: 29039212
Avian Dis. 1980 Jul-Sep;24(3):715-25
pubmed: 6255926
Transbound Emerg Dis. 2021 Sep 28;:
pubmed: 34581009