The Role and Mechanism of Lysine Methyltransferase and Arginine Methyltransferase in Kidney Diseases.
acute kidney injury
arginine methyltransferase
chronic kidney diseases
epigenetic modification
lysine methyltransferase
renal cell carcinoma
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
28
02
2022
accepted:
08
04
2022
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
14
5
2022
Statut:
epublish
Résumé
Methylation can occur in both histones and non-histones. Key lysine and arginine methyltransferases under investigation for renal disease treatment include enhancer of zeste homolog 2 (EZH2), G9a, disruptor of telomeric silencing 1-like protein (DOT1L), and protein arginine methyltransferases (PRMT) 1 and 5. Recent studies have shown that methyltransferases expression and activity are also increased in several animal models of kidney injury, such as acute kidney injury(AKI), obstructive nephropathy, diabetic nephropathy and lupus nephritis. The inhibition of most methyltransferases can attenuate kidney injury, while the role of methyltransferase in different animal models remains controversial. In this article, we summarize the role and mechanism of lysine methyltransferase and arginine methyltransferase in various kidney diseases and highlight methyltransferase as a potential therapeutic target for kidney diseases.
Identifiants
pubmed: 35559246
doi: 10.3389/fphar.2022.885527
pii: 885527
pmc: PMC9086358
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
885527Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK113256
Pays : United States
Informations de copyright
Copyright © 2022 Zhou, Chen, Li, Shi, Zhuang and Liu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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