Remote effects and biodistribution of pulmonary instilled silver nanoparticles in mice.
Biodistribution
Coating
Organ toxicity
Silver nanoparticles
Journal
NanoImpact
ISSN: 2452-0748
Titre abrégé: NanoImpact
Pays: Netherlands
ID NLM: 101676795
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
03
09
2020
revised:
27
02
2021
accepted:
09
03
2021
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
18
5
2022
Statut:
ppublish
Résumé
Silver nanoparticles (AgNPs) are the most commonly used nanoparticles (NPs) owing to their anti-microbial properties, and the pulmonary system provides a major portal of entry for these NPs used in aerosolized products. AgNPs have the potential to cause pulmonary toxicity, cross the alveolar-capillary barrier, and distribute to remote organs following pulmonary exposure. The mechanism underlying the effects of AgNPs, secondary to lung exposure, on the major organs including liver, spleen, kidney and brain, however, is still not completely understood. The aim of this study was to analyze the organ toxicity and distribution of pulmonary exposure to single dose of 5 mg/kg AgNPs (10 nm) with varying coatings (polyvinylpyrrolidone and citrate), at different time points (1 and 7 days), in Balb/C mice. Silver ions (Ag
Identifiants
pubmed: 35559967
pii: S2452-0748(21)00019-7
doi: 10.1016/j.impact.2021.100310
pii:
doi:
Substances chimiques
Interleukin-6
0
Ions
0
Tumor Necrosis Factor-alpha
0
Silver
3M4G523W1G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100310Informations de copyright
Copyright © 2021. Published by Elsevier B.V.