Ovulation induction is associated with altered growth but with preservation of normal metabolic function in murine offspring.
Agouti mice
DNA methylation
DOHaD
glucose metabolism
superovulation
Journal
F&S science
ISSN: 2666-335X
Titre abrégé: F S Sci
Pays: United States
ID NLM: 101765857
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
08
04
2021
revised:
03
06
2021
accepted:
04
06
2021
entrez:
13
5
2022
pubmed:
14
5
2022
medline:
20
5
2022
Statut:
ppublish
Résumé
To study the effects of ovulation induction on mouse postnatal health, with a focus on growth pattern and glucose tolerance. To study the effect of ovulation induction on DNA methylation, we took advantage of the agouti viable yellow (A Animal study. University Setting. Agouti viable yellow (A A Birth parameters and postnatal growth of the offspring were followed up to 29 weeks of age. Body composition analysis was performed by EchoMRI; fasting insulin, intraperitoneal glucose tolerance tests, and glucose-stimulated insulin secretion by beta cells were assessed to study glucose metabolism. Mice born to superovulated dams had lower survival rates, shorter anogenital distances, and shorter crown-rump lengths. Female mice generated by OI weighed less at birth, whereas male mice generated by OI had lower weight gain and had reduced lean mass. Glucose parameters, including islet functions, did not differ between the groups. No difference in agouti coat color was noted between the groups. Ovulation induction resulted in mice having increased morphometric differences at birth and male mice showing reduced weight gain but no difference in glucose tolerance or agouti coat color.
Identifiants
pubmed: 35560276
pii: S2666-335X(21)00048-3
doi: 10.1016/j.xfss.2021.06.002
pmc: PMC10434990
mid: NIHMS1920082
pii:
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
259-267Subventions
Organisme : NICHD NIH HHS
ID : R01 HD092267
Pays : United States
Informations de copyright
Copyright © 2021 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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