Periventricular gradient of T
Atlas-based assessment
Gradient of tissue damage
MP2RAGE
Multiple sclerosis
T(1)-relaxometry
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2022
2022
Historique:
received:
20
01
2022
revised:
24
03
2022
accepted:
12
04
2022
pubmed:
14
5
2022
medline:
20
5
2022
entrez:
13
5
2022
Statut:
ppublish
Résumé
Pathology in multiple sclerosis is not homogenously distributed. Recently, it has been shown that structures adjacent to CSF are more severely affected. A gradient of brain tissue involvement was shown with more severe pathology in periventricular areas and in proximity to brain surfaces such as the subarachnoid spaces and ependyma, and hence termed the "surface-in" gradient. Here, we study whether (i) the surface-in gradient of periventricular tissue alteration measured by T Forty-seven patients with early multiple sclerosis, 52 with progressive multiple sclerosis, and 92 healthy controls were included in the study. Isotropic 3D T Patients with early and progressive multiple sclerosis demonstrated a periventricular gradient of T Our results suggest that the surface-in white matter gradient of tissue alteration is detectable with T1 relaxometry and is already present at clinical disease onset. The periventricular gradients correlate with clinical disability. The periventricular gradient in normal-appearing white matter may thus qualify as a promising biomarker for monitoring of disease activity from an early stage in all phenotypes of multiple sclerosis.
Identifiants
pubmed: 35561554
pii: S2213-1582(22)00074-2
doi: 10.1016/j.nicl.2022.103009
pmc: PMC9112026
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT03706118']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103009Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
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