Gradient and Acceleration of Decline in Physical and Cognitive Functions in Older Adults: A Disparity Analysis.

Acceleration Aged Aged, 80 and over Clinical Studies as Topic Cognition Cross-Sectional Studies Gait Humans Middle Aged Walking Speed
Aging Dual decliner Rate of decline cognition Rate of decline walking speed

Journal

The journals of gerontology. Series A, Biological sciences and medical sciences
ISSN: 1758-535X
Titre abrégé: J Gerontol A Biol Sci Med Sci
Pays: United States
ID NLM: 9502837

Informations de publication

Date de publication:
12 08 2022
Historique:
received: 26 08 2021
pubmed: 14 5 2022
medline: 17 8 2022
entrez: 13 5 2022
Statut: ppublish

Résumé

Substantive previous work has shown that both gait speed and global cognition decline as people age. Rates of their decline, as opposed to cross-sectional measurements, could be more informative of future functional status and other clinical outcomes because they more accurately represent deteriorating systems. Additionally, understanding the sex and racial disparity in the speed of deterioration, if any, is also important as ethnic minorities are at an increased risk of mobility disability and dementia. Data from 2 large longitudinal intervention studies were integrated. Rates of decline were derived from individual-level measures of gait speed of 400-m walk and scores on the Modified Mini Mental State Examination (3MSE). We also assessed age-associated declines and accelerations in changes across the ages represented in the studies (age range 53-90). The mean rate of decline in 400-m gait speed across individuals was 0.03 m/s per year, and multivariable analysis showed a significant acceleration in decline of -0.0013 m/s/y2 (p < .001). Both race and sex moderated the rate of decline. For global cognition, the mean rate of decline was 0.05 of a point per year on the 3MSE scale, and acceleration in the rate of decline was significant (-0.017 point/y2, p < .001), but neither sex nor race moderated the decline. Rate of decline in physical but not cognitive function appears moderated by sex and race. This finding, as well as rates and accelerations of decline estimated herein, could inform future intervention studies. NCT00017953 (Look AHEAD); NCT01410097 (Look AHEAD ancillary); NCT00116194 (LIFE).

Sections du résumé

BACKGROUND
Substantive previous work has shown that both gait speed and global cognition decline as people age. Rates of their decline, as opposed to cross-sectional measurements, could be more informative of future functional status and other clinical outcomes because they more accurately represent deteriorating systems. Additionally, understanding the sex and racial disparity in the speed of deterioration, if any, is also important as ethnic minorities are at an increased risk of mobility disability and dementia.
METHOD
Data from 2 large longitudinal intervention studies were integrated. Rates of decline were derived from individual-level measures of gait speed of 400-m walk and scores on the Modified Mini Mental State Examination (3MSE). We also assessed age-associated declines and accelerations in changes across the ages represented in the studies (age range 53-90).
RESULTS
The mean rate of decline in 400-m gait speed across individuals was 0.03 m/s per year, and multivariable analysis showed a significant acceleration in decline of -0.0013 m/s/y2 (p < .001). Both race and sex moderated the rate of decline. For global cognition, the mean rate of decline was 0.05 of a point per year on the 3MSE scale, and acceleration in the rate of decline was significant (-0.017 point/y2, p < .001), but neither sex nor race moderated the decline.
CONCLUSION
Rate of decline in physical but not cognitive function appears moderated by sex and race. This finding, as well as rates and accelerations of decline estimated herein, could inform future intervention studies.
CLINICAL TRIALS REGISTRATION NUMBER
NCT00017953 (Look AHEAD); NCT01410097 (Look AHEAD ancillary); NCT00116194 (LIFE).

Identifiants

DOI: 10.1093/gerona/glac109 PMID: 35562076 PMC: PMC9373944
pubmed: 35562076
pii: 6585683
doi: 10.1093/gerona/glac109
pmc: PMC9373944
doi:

Banques de données

ClinicalTrials.gov
['NCT01410097', 'NCT00116194', 'NCT00017953']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Intramural Research Support, U.S. Gov't, P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1603-1611

Subventions

Organisme : NIA NIH HHS
ID : P30 AG024827
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : NHLBI NIH HHS
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000056
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK056992
Pays : United States
Organisme : VA
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK092237
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG059624
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR001066
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025758
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072947
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG021332
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK048520
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024153
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK57136
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK046204
Pays : United States
Organisme : NINR NIH HHS
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR002719
Pays : United States
Organisme : NIH HHS
ID : UO1AG22376
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG031679
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025744
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000051
Pays : United States
Organisme : NIA NIH HHS
ID : 3U01AG022376-05A2S
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000142
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR001346
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003142
Pays : United States
Organisme : CDC HHS
Pays : United States

Informations de copyright

© The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Références

BMJ. 2010 Sep 09;341:c4467
pubmed: 20829298
Neurobiol Aging. 2009 Apr;30(4):507-14
pubmed: 19231028
J Gerontol A Biol Sci Med Sci. 2021 Mar 31;76(4):710-715
pubmed: 32841312
Aging Clin Exp Res. 2017 Apr;29(2):215-221
pubmed: 27068303
J Gerontol B Psychol Sci Soc Sci. 2003 Nov;58(6):S327-37
pubmed: 14614120
BMC Geriatr. 2019 Jul 5;19(1):186
pubmed: 31277579
Int J Epidemiol. 2016 Aug;45(4):1135-1145
pubmed: 27272182
J Appl Gerontol. 2020 May;39(5):502-508
pubmed: 29909728
Geroscience. 2020 Apr;42(2):585-593
pubmed: 32002783
J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1194-200
pubmed: 17167162
Neuropsychology. 2021 Feb;35(2):141-156
pubmed: 33764108
Alzheimer Dis Assoc Disord. 2021 Jan-Mar 01;35(1):23-29
pubmed: 33629977
J Gerontol A Biol Sci Med Sci. 2009 Aug;64(8):896-901
pubmed: 19349593
Age Ageing. 2009 Sep;38(5):509-14
pubmed: 19549981
Gerontology. 2018;64(3):212-221
pubmed: 29232671
J Gerontol A Biol Sci Med Sci. 2013 Apr;68(4):456-64
pubmed: 23051974
J Gerontol A Biol Sci Med Sci. 2006 Oct;61(10):1059-64
pubmed: 17077199
J Gerontol A Biol Sci Med Sci. 2017 Jul 01;72(suppl_1):S5-S10
pubmed: 28575265
Age Ageing. 2020 Oct 23;49(6):995-1002
pubmed: 32559288
Neurobiol Aging. 2021 Jan;97:49-55
pubmed: 33152563
J Am Geriatr Soc. 2001 Dec;49(12):1646-50
pubmed: 11843998
Am J Geriatr Psychiatry. 2017 Aug;25(8):889-899
pubmed: 28433548
Epidemiology. 2018 Jan;29(1):151-159
pubmed: 28863046
Arch Clin Neuropsychol. 2002 Feb;17(2):171-7
pubmed: 14589746
Med Sci Sports Exerc. 1988 Apr;20(2):161-6
pubmed: 3367751
J Am Geriatr Soc. 2015 Jun;63(6):1129-36
pubmed: 26096387
J Gerontol A Biol Sci Med Sci. 2002 Apr;57(4):M228-35
pubmed: 11909888
J Consult Clin Psychol. 1987 Feb;55(1):96-100
pubmed: 3571664
Health Aff (Millwood). 2014 Apr;33(4):580-6
pubmed: 24711318
J Gerontol A Biol Sci Med Sci. 2010 Oct;65(10):1093-100
pubmed: 20581339
J Gerontol A Biol Sci Med Sci. 2014 Sep;69(9):1101-8
pubmed: 24619151
J Gerontol A Biol Sci Med Sci. 2013 Sep;68(9):1059-67
pubmed: 23666944
BMC Geriatr. 2021 Jun 2;21(1):340
pubmed: 34078276
Int Psychogeriatr. 2019 May;31(5):693-701
pubmed: 30021667
Hypertension. 2019 Feb;73(2):310-318
pubmed: 30624986
J Gerontol B Psychol Sci Soc Sci. 2012 Mar;67(2):238-48
pubmed: 22391749
J Am Geriatr Soc. 2017 May;65(5):966-972
pubmed: 28067945
Diabetes Care. 2016 May;39(5):764-71
pubmed: 27208378
N Engl J Med. 2013 Jul 11;369(2):145-54
pubmed: 23796131
J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):943-948
pubmed: 29917045
Psychol Aging. 2003 Jun;18(2):318-31
pubmed: 12825779
J Alzheimers Dis. 2020;75(4):1437-1446
pubmed: 32417775
J Gerontol A Biol Sci Med Sci. 2017 May 01;72(5):669-675
pubmed: 27449140
Geriatr Gerontol Int. 2014 Jan;14(1):23-31
pubmed: 23682773
J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):784-791
pubmed: 31825084
J Am Geriatr Soc. 2012 May;60(5):922-6
pubmed: 22587854
JAMA. 2014 Jun 18;311(23):2387-96
pubmed: 24866862

Auteurs

Edward H Ip (EH)

Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
ORCID: 0000-0002-4811-4205

Shyh-Huei Chen (SH)

Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

W Jack Rejeski (WJ)

Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina, USA.

Karen Bandeen-Roche (K)

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Kathleen M Hayden (KM)

Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
ORCID: 0000-0002-7745-3513

Christina E Hugenschmidt (CE)

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

June Pierce (J)

Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Michael E Miller (ME)

Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Jaime L Speiser (JL)

Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
ORCID: 0000-0003-0679-8730

Stephen B Kritchevsky (SB)

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
ORCID: 0000-0003-3336-6781

Denise K Houston (DK)

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Robert L Newton (RL)

Population and Public Health, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.

Stephen R Rapp (SR)

Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Dalane W Kitzman (DW)

Sections of Cardiovascular and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiques › Déplacement › Accélération › Gradient and Acceleration of Decline in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Gradient and Acceleration of Decline in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Gradient and Acceleration of Decline in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Gradient and Acceleration of Decline in...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Gradient and Acceleration of Decline in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Gradient and Acceleration of Decline in...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Locomotion › Démarche › Gradient and Acceleration of Decline in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gradient and Acceleration of Decline in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Gradient and Acceleration of Decline in...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Locomotion › Démarche › Vitesse de marche › Gradient and Acceleration of Decline in...