Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study.
Mendelian randomization
Smoking
infertility
Journal
Fertility and sterility
ISSN: 1556-5653
Titre abrégé: Fertil Steril
Pays: United States
ID NLM: 0372772
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
28
10
2021
revised:
30
03
2022
accepted:
01
04
2022
pubmed:
14
5
2022
medline:
23
6
2022
entrez:
13
5
2022
Statut:
ppublish
Résumé
To investigate the association between smoking and infertility. Prospective study. Nationwide cohort. 28,606 women and 27,096 men with questionnaire and genotype information from the Norwegian Mother, Father, and Child Cohort Study. Self-reported information on smoking (having ever smoked [both sexes], age at initiation [women only], cessation [women only], and cigarettes/week in current smokers [both sexes]) was gathered. Genetically predetermined levels or likelihood of presenting these traits were estimated for Mendelian randomization. Infertility (time-to-pregnancy ≥12 months). Having ever smoked was unrelated to infertility in women or men. Higher smoking intensity in women was associated with greater infertility odds (+1 standard deviation [SD, 48 cigarettes/week]: odds ratio [OR] We did not find robust evidence of an effect of smoking on infertility. This may be due to a true lack of effect, weak genetic instruments, or other kinds of confounding.
Identifiants
pubmed: 35562204
pii: S0015-0282(22)00211-4
doi: 10.1016/j.fertnstert.2022.04.001
pmc: PMC7612999
mid: EMS146213
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
180-190Subventions
Organisme : British Heart Foundation
ID : RG/13/13/30194
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00002/7
Pays : United Kingdom
Organisme : European Research Council
ID : 669545
Pays : International
Organisme : British Heart Foundation
ID : RG/18/13/33946
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/12/2/29428
Pays : United Kingdom
Organisme : European Research Council
ID : 947684
Pays : International
Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
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