Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neurons.
IGF-I
central control of metabolism
circadian activity
feeding entrainment
orexin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Apr 2022
23 Apr 2022
Historique:
received:
31
03
2022
revised:
20
04
2022
accepted:
21
04
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Uncoupling of metabolism and circadian activity is associated with an increased risk of a wide spectrum of pathologies. Recently, insulin and the closely related insulin-like growth factor I (IGF-I) were shown to entrain feeding patterns with circadian rhythms. Both hormones act centrally to modulate peripheral glucose metabolism; however, whereas central targets of insulin actions are intensely scrutinized, those mediating the actions of IGF-I remain less defined. We recently showed that IGF-I targets orexin neurons in the lateral hypothalamus, and now we evaluated whether IGF-I modulates orexin neurons to align circadian rhythms with metabolism. Mice with disrupted IGF-IR activity in orexin neurons (Firoc mice) showed sexually dimorphic alterations in daily glucose rhythms and feeding activity patterns which preceded the appearance of metabolic disturbances. Thus, Firoc males developed hyperglycemia and glucose intolerance, while females developed obesity. Since IGF-I directly modulates orexin levels and hepatic expression of KLF genes involved in circadian and metabolic entrainment in an orexin-dependent manner, it seems that IGF-I entrains metabolism and circadian rhythms by modulating the activity of orexin neurons.
Identifiants
pubmed: 35563069
pii: ijms23094679
doi: 10.3390/ijms23094679
pmc: PMC9101627
pii:
doi:
Substances chimiques
Insulin
0
Orexins
0
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biomedical Research Networking Center on Neurodegenerative Diseases
ID : PIE14/00061
Organisme : Ministerio de ciencia e innovación. Agencia estatal de investigación
ID : PID2019-104376RB-I00
Organisme : Comunidad de Madrid
ID : B2017/BMD-3700
Références
J Neurosci. 2004 Nov 17;24(46):10493-501
pubmed: 15548664
Diabetologia. 2006 Jul;49(7):1619-28
pubmed: 16752180
Neuroscience. 1990;35(3):601-8
pubmed: 2199843
Mol Metab. 2018 Mar;9:141-155
pubmed: 29398615
Neuron. 2001 May;30(2):345-54
pubmed: 11394998
J Neurosci. 2014 Mar 5;34(10):3607-21
pubmed: 24599460
PPAR Res. 2014;2014:653017
pubmed: 24693278
Eur J Neurosci. 2017 May;45(10):1325-1332
pubmed: 28370506
Diabetes. 2015 Feb;64(2):459-70
pubmed: 25249578
J Neurosci. 2004 Sep 1;24(35):7604-13
pubmed: 15342726
J Mol Med (Berl). 2002 Jun;80(6):329-42
pubmed: 12072908
Prog Brain Res. 2012;199:1-18
pubmed: 22877656
Front Nutr. 2019 Aug 28;6:132
pubmed: 31555652
BMC Biol. 2020 Nov 6;18(1):160
pubmed: 33158435
Nature. 2012 Nov 15;491(7424):348-56
pubmed: 23151577
Neuropharmacology. 2014 Oct;85:451-60
pubmed: 24951857
Mol Cell Biol. 2010 Jun;30(12):3059-70
pubmed: 20385766
Endocr Rev. 2019 Feb 1;40(1):137-152
pubmed: 30307551
Diabetologia. 2008 Apr;51(4):657-67
pubmed: 18256806
Front Endocrinol (Lausanne). 2015 Apr 27;6:61
pubmed: 25964778
Cell. 2019 May 30;177(6):1448-1462.e14
pubmed: 31150621
Cereb Cortex. 2018 Jun 1;28(6):2007-2014
pubmed: 28449086
J Neurosci. 2011 Jul 20;31(29):10529-39
pubmed: 21775598
Mol Metab. 2014 Mar 19;3(4):372-83
pubmed: 24944897
PLoS One. 2017 Mar 3;12(3):e0173174
pubmed: 28257428
Front Neuroendocrinol. 2014 Jan;35(1):111-39
pubmed: 24287074
Aging Cell. 2016 Feb;15(1):181-6
pubmed: 26534869
FASEB J. 2020 Dec;34(12):15975-15990
pubmed: 33070417
Front Endocrinol (Lausanne). 2013 May 16;4:57
pubmed: 23730297
Front Behav Neurosci. 2014 Jul 23;8:244
pubmed: 25100956
J Physiol Sci. 2017 Jan;67(1):1-10
pubmed: 27084533
Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5464-E5473
pubmed: 28630298
Sci Adv. 2020 Nov 6;6(45):
pubmed: 33158870
Nat Rev Endocrinol. 2019 Jul;15(7):393-405
pubmed: 31073218
PLoS One. 2011;6(9):e24187
pubmed: 21912674
Neuropeptides. 2013 Jun;47(3):213-9
pubmed: 23510906
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15172-7
pubmed: 18779586
Mol Psychiatry. 2022 Apr;27(4):2182-2196
pubmed: 35115701
Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5813-8
pubmed: 21402951
Front Endocrinol (Lausanne). 2013 Mar 06;4:18
pubmed: 23508038
Neuron. 2006 Jun 1;50(5):711-22
pubmed: 16731510
Biol Psychiatry. 2017 Apr 15;81(8):683-692
pubmed: 27955897
Elife. 2014 Dec 19;3:
pubmed: 25525750
Nature. 2010 Jul 29;466(7306):627-31
pubmed: 20562852
Nucleic Acids Res. 2001 May 1;29(9):e45
pubmed: 11328886
Front Neurosci. 2013 Oct 14;7:185
pubmed: 24133410
Nature. 2007 Nov 15;450(7168):420-4
pubmed: 17943086
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6808-13
pubmed: 19366674
Sci Rep. 2016 Oct 31;6:36035
pubmed: 27796320
Neuron. 2003 Jun 5;38(5):701-13
pubmed: 12797956
Diabetes. 2001 May;50(5):1110-8
pubmed: 11334415
J Clin Endocrinol Metab. 2002 Sep;87(9):4356-60
pubmed: 12213898
Diabetes. 2021 Oct;70(10):2237-2249
pubmed: 34285117
PLoS One. 2008 Sep 15;3(9):e3194
pubmed: 18791643
Diabetes. 2009 Sep;58(9):1998-2005
pubmed: 19592616
Int J Mol Sci. 2019 May 13;20(9):
pubmed: 31086044
Nature. 2011 Dec 14;480(7378):552-6
pubmed: 22170608
Cell. 2019 May 2;177(4):896-909.e20
pubmed: 31030999
Trends Endocrinol Metab. 2010 May;21(5):277-86
pubmed: 20106676
Brain Res. 2017 Sep 15;1671:93-101
pubmed: 28709906
FEBS Lett. 2011 May 20;585(10):1412-26
pubmed: 21414317
Neurosci Biobehav Rev. 1988 Summer;12(2):101-9
pubmed: 2845312
Front Endocrinol (Lausanne). 2017 Mar 14;8:44
pubmed: 28352249
J Am Geriatr Soc. 1999 Nov;47(11):1312-8
pubmed: 10573439