The Role of Epigenetics in Primary Biliary Cholangitis.
autoimmunity
chromosome X
non-coding RNA
sex bias
somatic mosaicism
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Apr 2022
28 Apr 2022
Historique:
received:
11
04
2022
revised:
25
04
2022
accepted:
26
04
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Primary Biliary Cholangitis (PBC) is a rare autoimmune disease of the liver, affecting mostly females. There is evidence that epigenetic changes have a pathogenic role in PBC. Epigenetic modifications are related to methylation of CpG DNA islands, post-translational modifications of histone proteins, and non-coding RNAs. In PBC, there are data showing a dysregulation of all these levels, especially in immune cells. In addition, epigenetics seems to be involved in complex phenomena such as X monosomy or abnormalities in the process of X chromosome inactivation, which have been reported in PBC and appear to influence its sex imbalance and pathogenesis. We review here historical data on epigenetic modifications in PBC, present new data, and discuss possible links among X-chromosome abnormalities at a genetic and epigenetic level, PBC pathogenesis, and PBC sex imbalance.
Identifiants
pubmed: 35563266
pii: ijms23094873
doi: 10.3390/ijms23094873
pmc: PMC9105933
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero della Salute
ID : PE-2016-02363915
Organisme : Ministero della Salute
ID : GR-2018-12367794
Références
Mol Biol Cell. 2018 Oct 1;29(20):2458-2469
pubmed: 30091656
J Autoimmun. 2018 Dec;95:124-132
pubmed: 30509386
J Clin Transl Hepatol. 2020 Mar 28;8(1):49-60
pubmed: 32274345
PLoS Genet. 2013;9(9):e1003777
pubmed: 24039610
Mol Cell. 2015 Jun 4;58(5):870-85
pubmed: 25921068
Nature. 2017 Oct 11;550(7675):244-248
pubmed: 29022598
Nat Rev Gastroenterol Hepatol. 2020 Feb;17(2):93-110
pubmed: 31819247
J Exp Med. 1995 May 1;181(5):1835-45
pubmed: 7536796
RNA. 2014 Nov;20(11):1666-70
pubmed: 25234927
Nucleic Acids Res. 2014 Jan;42(Database issue):D68-73
pubmed: 24275495
Hepatology. 2009 Mar;49(3):871-9
pubmed: 19185000
Epigenetics. 2011 Jan;6(1):95-102
pubmed: 20864813
Hum Genet. 1994 Sep;94(3):295-8
pubmed: 8076947
Am J Hum Genet. 1998 Nov;63(5):1464-72
pubmed: 9792875
Chromosome Res. 2009;17(5):649-58
pubmed: 19802705
Inflamm Regen. 2020 Aug 3;40:16
pubmed: 32922569
Clin Res Hepatol Gastroenterol. 2016 Dec;40(6):650-659
pubmed: 27341761
Nat Rev Genet. 2016 Jan;17(1):47-62
pubmed: 26666209
Hepatology. 2012 Jan;55(1):153-60
pubmed: 21898485
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D109-11
pubmed: 14681370
Hepatology. 2007 Aug;46(2):456-62
pubmed: 17659578
Eur J Med Genet. 2021 Sep;64(9):104292
pubmed: 34303876
Front Immunol. 2014 Mar 28;5:128
pubmed: 24734033
Hepatology. 2006 Mar;43(3):525-31
pubmed: 16496326
Clin Epigenetics. 2015 Jul 07;7:61
pubmed: 26150899
Am J Epidemiol. 2014 Feb 15;179(4):492-8
pubmed: 24401563
Cell. 2013 Nov 7;155(4):934-47
pubmed: 24119843
JHEP Rep. 2020 Nov 04;3(1):100202
pubmed: 33474546
Nucleic Acids Res. 2008 Jan;36(Database issue):D154-8
pubmed: 17991681
Nature. 2020 Sep;585(7823):79-84
pubmed: 32663838
Nature. 1961 Apr 22;190:372-3
pubmed: 13764598
Curr Opin Immunol. 2016 Dec;43:24-31
pubmed: 27588918
Hepatology. 2012 Aug;56(2):687-97
pubmed: 22383162
Lancet. 2004 Feb 14;363(9408):533-5
pubmed: 14975617
Hepatology. 2005 Nov;42(5):1194-202
pubmed: 16250040
N Engl J Med. 2018 Apr 05;378(14):1323-1334
pubmed: 29617578
Gut. 1984 Feb;25(2):133-7
pubmed: 6363217
Int J Mol Med. 2016 Jul;38(1):131-8
pubmed: 27246196
Mech Ageing Dev. 2004 Aug;125(8):563-73
pubmed: 15336914
Nat Rev Genet. 2021 Apr;22(4):235-250
pubmed: 33244170
Curr Opin Genet Dev. 2016 Feb;36:27-33
pubmed: 27107478
Clin Dev Immunol. 2012;2012:610504
pubmed: 22693524
Cell. 2011 Jan 7;144(1):27-40
pubmed: 21215367
Cell. 2018 Mar 22;173(1):20-51
pubmed: 29570994
Science. 2020 Sep 11;369(6509):
pubmed: 32913072
Hepatology. 2001 Dec;34(6):1083-8
pubmed: 11731995
Nature. 2013 Mar 21;495(7441):333-8
pubmed: 23446348
J Gastroenterol Hepatol. 2013 Mar;28(3):543-50
pubmed: 23173724
Cell Physiol Biochem. 2017;44(4):1271-1281
pubmed: 29183005
J Immunol. 2009 Jun 15;182(12):7738-48
pubmed: 19494298
J Autoimmun. 2012 May;38(2-3):J187-92
pubmed: 22178198
J Hepatol. 2010 Jul;53(1):162-9
pubmed: 20471130
Genome Res. 2012 Sep;22(9):1760-74
pubmed: 22955987
Nat Genet. 2006 Jan;38(1):47-53
pubmed: 16341221
Nat Immunol. 2007 Apr;8(4):345-50
pubmed: 17375096
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8454-9
pubmed: 12832623
Front Immunol. 2020 May 29;11:976
pubmed: 32547545
Hepatology. 2021 Sep;74(3):1652-1659
pubmed: 33630308
Gastroenterology. 2008 May;134(5):1482-93
pubmed: 18471521
Autoimmun Rev. 2017 Sep;16(9):885-896
pubmed: 28698093
J Autoimmun. 2008 Sep;31(2):110-5
pubmed: 18644699
Nature. 2020 Feb;578(7795):455-460
pubmed: 32025035
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2806-11
pubmed: 24550311
Mol Med Rep. 2016 Oct;14(4):3350-6
pubmed: 27511723
Nature. 2015 Feb 19;518(7539):337-43
pubmed: 25363779
J Autoimmun. 2009 May-Jun;32(3-4):246-53
pubmed: 19345069
Sci Rep. 2016 Feb 03;6:20559
pubmed: 26838806
Immunol Rev. 2009 May;229(1):152-72
pubmed: 19426221
Mutat Res Rev Mutat Res. 2020 Oct - Dec;786:108335
pubmed: 33339583
Hepatology. 2008 Feb;47(2):552-62
pubmed: 17999420
RNA. 2013 Feb;19(2):141-57
pubmed: 23249747
J Hepatol. 2020 Oct;73(4):965-966
pubmed: 32709365
Lancet. 2020 Dec 12;396(10266):1915-1926
pubmed: 33308474
Mutagenesis. 2011 Jan;26(1):125-32
pubmed: 21164193
J Biol. 2006;5(1):3
pubmed: 16507155
Proc Natl Acad Sci U S A. 2019 Dec 10;:
pubmed: 31822606
J Hepatol. 2018 Nov;69(5):1123-1135
pubmed: 30006067
Gut. 2018 Mar;67(3):534-541
pubmed: 28213609
Nature. 2012 Jan 18;482(7383):53-8
pubmed: 22258507
J Clin Immunol. 2011 Jun;31(3):346-55
pubmed: 21243522
Gastroenterology. 2013 Mar;144(3):560-569.e7; quiz e13-4
pubmed: 23246637
Exp Biol Med (Maywood). 2018 Jan;243(2):184-189
pubmed: 29307284
Gastroenterology. 2021 Jun;160(7):2483-2495.e26
pubmed: 33675743
J Autoimmun. 2005 Sep;25(2):126-32
pubmed: 16243485
J Hered. 2015 Sep-Oct;106(5):666-71
pubmed: 26268243
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
pubmed: 16381832
Hepatology. 2003 Nov;38(5):1250-7
pubmed: 14578864
PLoS One. 2013 Jun 12;8(6):e66086
pubmed: 23776611
Nature. 2015 Jun 11;522(7555):179-84
pubmed: 26017310
Nature. 2005 Mar 17;434(7031):400-4
pubmed: 15772666
PLoS One. 2014 Oct 27;9(10):e111424
pubmed: 25347847
Autoimmun Rev. 2012 Mar;11(5):301-4
pubmed: 20230920
Am J Hum Genet. 1988 Nov;43(5):733-40
pubmed: 3189336
J Hepatol. 2018 Dec;69(6):1371-1383
pubmed: 30193962
Hepatology. 2018 Apr;67(4):1420-1440
pubmed: 28922472
Mol Cell. 2013 Sep 26;51(6):792-806
pubmed: 24035497
Hepatology. 1997 Jan;25(1):12-7
pubmed: 8985258