MicroRNA-449a Inhibits Triple Negative Breast Cancer by Disturbing DNA Repair and Chromatid Separation.
DNA repair
chromatid separation
chromosomal instability
microRNA449a
triple negative breast cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 May 2022
04 May 2022
Historique:
received:
31
03
2022
revised:
26
04
2022
accepted:
03
05
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Chromosomal instability (CIN) can be a driver of tumorigenesis but is also a promising therapeutic target for cancer associated with poor prognosis such as triple negative breast cancer (TNBC). The treatment of TNBC cells with defects in DNA repair genes with poly(ADP-ribose) polymerase inhibitor (PARPi) massively increases CIN, resulting in apoptosis. Here, we identified a previously unknown role of microRNA-449a in CIN. The transfection of TNBC cell lines HCC38, HCC1937 and HCC1395 with microRNA-449a mimics led to induced apoptosis, reduced cell proliferation, and reduced expression of genes in homology directed repair (HDR) in microarray analyses.
Identifiants
pubmed: 35563522
pii: ijms23095131
doi: 10.3390/ijms23095131
pmc: PMC9102308
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
MicroRNAs
0
Poly(ADP-ribose) Polymerase Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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