Cyanine-Doped Nanofiber Mats for Laser Tissue Bonding.
chitosan
dermis
electrospun nanofibers
indocyanine green
wound dressing
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
09 May 2022
09 May 2022
Historique:
received:
31
03
2022
revised:
28
04
2022
accepted:
05
05
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
15
5
2022
Statut:
epublish
Résumé
In spite of an extensive body of academic initiatives and innovative products, the toolkit of wound dressing has always revolved around a few common concepts such as adhesive patches and stitches and their variants. Our work aims at an alternative solution for an immediate restitutio ad integrum of the mechanical functionality in cutaneous repairs. We describe the fabrication and the application of electrospun mats of bioactive nanofibers all made of biocompatible components such as a natural polysaccharide and a cyanine dye for use as laser-activatable plasters, resembling the ultrastructure of human dermis. In particular, we investigate their morphological features and mechanical moduli under conditions of physiological relevance, and we test their use to bind a frequent benchmark of connective tissue as rabbit tendon and a significant case of clinical relevance as human dermis. Altogether, our results point to the feasibility of a new material for wound dressing combining translational potential, strength close to human dermis, extensibility exceeding 15% and state-of-art adhesive properties.
Identifiants
pubmed: 35564323
pii: nano12091613
doi: 10.3390/nano12091613
pmc: PMC9105542
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ente Cassa di Risparmio di Firenze
ID : MONSTER
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