Bone Progenitors Pull the Strings on the Early Metabolic Rewiring Occurring in Prostate Cancer Cells.
PKA
bone metastasis
gene signature
lipid metabolism
metabolism
prostate cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
21 Apr 2022
21 Apr 2022
Historique:
received:
06
04
2022
accepted:
19
04
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
15
5
2022
Statut:
epublish
Résumé
Metastatic prostate cancer (PCa) cells soiling in the bone require a metabolic adaptation. Here, we identified the metabolic genes fueling the seeding of PCa in the bone niche. Using a transwell co-culture system of PCa (PC3) and bone progenitor cells (MC3T3 or Raw264.7), we assessed the transcriptome of PC3 cells modulated by soluble factors released from bone precursors. In a Principal Component Analysis using transcriptomic data from human PCa samples (GSE74685), the altered metabolic genes found in vitro were able to stratify PCa patients in two defined groups: primary PCa and bone metastasis, confirmed by an unsupervised clustering analysis. Thus, the early transcriptional metabolic profile triggered in the in vitro model has a clinical correlate in human bone metastatic samples. Further, the expression levels of five metabolic genes (
Identifiants
pubmed: 35565211
pii: cancers14092083
doi: 10.3390/cancers14092083
pmc: PMC9104818
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NLM NIH HHS
ID : R01 LM013236
Pays : United States
Organisme : University of Buenos Aires
ID : 20020170100585BA
Organisme : Agencia Nacional de Promoción Científica y Tecnológica
ID : PICT-RAICES-2018-02639
Organisme : Agencia Nacional de Promoción Científica y Tecnológica
ID : PICT-2019-2019-03215
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