Regulatory Role of the Adipose Microenvironment on Ovarian Cancer Progression.
adipocyte
chemoresistance
metabolic reprogramming
metastasis
ovarian cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
01 May 2022
01 May 2022
Historique:
received:
08
04
2022
revised:
26
04
2022
accepted:
27
04
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
15
5
2022
Statut:
epublish
Résumé
The tumor microenvironment of ovarian cancer is the peritoneal cavity wherein adipose tissue is a major component. The role of the adipose tissue in support of ovarian cancer progression has been elucidated in several studies from the past decades. The adipocytes, in particular, are a major source of factors, which regulate all facets of ovarian cancer progression such as acquisition of chemoresistance, enhanced metastatic potential, and metabolic reprogramming. In this review, we summarize the relevant studies, which highlight the role of adipocytes in ovarian cancer progression and offer insights into unanswered questions and possible future directions of research.
Identifiants
pubmed: 35565396
pii: cancers14092267
doi: 10.3390/cancers14092267
pmc: PMC9101128
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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