Circulating miRNAs in Breast Cancer Diagnosis and Prognosis.
biomarkers
breast cancer
extracellular vesicles
liquid biopsy
miRNA
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
07 May 2022
07 May 2022
Historique:
received:
01
04
2022
revised:
22
04
2022
accepted:
28
04
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
15
5
2022
Statut:
epublish
Résumé
Great improvement has been made in the diagnosis and therapy of breast cancer patients. However, the identification of biomarkers for early diagnosis, prognosis, therapy assessment and monitoring, including drug resistance and the early detection of micro-metastases, is still lacking. Recently, circulating microRNAs (miRNAs), circulating freely in the blood stream or entrapped in extracellular vesicles (EVs), have been shown to have a potential diagnostic, prognostic or predictive power. In this review, recent findings are summarized, both at a preclinical and clinical level, related to miRNA applicability in the context of breast cancer. Different aspects, including clinical and technical challenges, are discussed, describing the potentialities of miRNA use in breast cancer. Even though more methodological standardized studies conducted in larger and selected patient cohorts are needed to support the effective clinical utility of miRNA as biomarkers, they could represent novel and accessible tools to be transferred into clinical practice.
Identifiants
pubmed: 35565446
pii: cancers14092317
doi: 10.3390/cancers14092317
pmc: PMC9101355
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Compagnia di San Paolo
ID : ID ROL: 32134
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