Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer's Disease.
glial cells
imaging
neurodegenerative disease
neuroinflammation
neuroprotection
nicotinic acetylcholine receptors
subpopulation
subtype
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
27 Apr 2022
27 Apr 2022
Historique:
received:
28
03
2022
revised:
21
04
2022
accepted:
25
04
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
18
5
2022
Statut:
epublish
Résumé
Amyloid-β (Aβ) accumulation and tauopathy are considered the pathological hallmarks of Alzheimer's disease (AD), but attenuation in choline signaling, including decreased nicotinic acetylcholine receptors (nAChRs), is evident in the early phase of AD. Currently, there are no drugs that can suppress the progression of AD due to a limited understanding of AD pathophysiology. For this, diagnostic methods that can assess disease progression non-invasively before the onset of AD symptoms are essential, and it would be valuable to incorporate the concept of neurotheranostics, which simultaneously enables diagnosis and treatment. The neuroprotective pathways activated by nAChRs are attractive targets as these receptors may regulate microglial-mediated neuroinflammation. Microglia exhibit both pro- and anti-inflammatory functions that could be modulated to mitigate AD pathogenesis. Currently, single-cell analysis is identifying microglial subpopulations that may have specific functions in different stages of AD pathologies. Thus, the ability to image nAChRs and microglia in AD according to the stage of the disease in the living brain may lead to the development of new diagnostic and therapeutic methods. In this review, we summarize and discuss the recent findings on the nAChRs and microglia, as well as their methods for live imaging in the context of diagnosis, prophylaxis, and therapy for AD.
Identifiants
pubmed: 35566132
pii: molecules27092780
doi: 10.3390/molecules27092780
pmc: PMC9102429
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Receptors, Nicotinic
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : Private University Research Branding Project
Organisme : Japan Society for the Promotion of Science
ID : 20H03569 to KT; 19K07854 to KN; 21K06586 to YK; 17K09783; 20K0789 to SS, 20K20588 to IT
Organisme : Hoansha Foundation
ID : to (KT)
Organisme : Kobayashi Foundation
ID : to (KT)
Organisme : Smoking Research Foundation
ID : to KT, YK and SS
Références
Environ Sci Pollut Res Int. 2020 Dec;27(36):44659-44672
pubmed: 32201908
J Alzheimers Dis. 2018;61(4):1355-1365
pubmed: 29376856
Eur J Pharmacol. 1981 Apr 24;71(1):173-5
pubmed: 6263650
Neuron. 2019 Jan 16;101(2):207-223.e10
pubmed: 30606613
Brain Behav Immun. 2021 Jan;91:784-787
pubmed: 33002632
Annu Rev Pharmacol Toxicol. 2002;42:135-63
pubmed: 11807168
Pharmacol Rev. 2021 Jul;73(3):1118-1149
pubmed: 34301823
Exp Mol Med. 2011 Jan 31;43(1):7-14
pubmed: 21088470
J Alzheimers Dis. 2019;72(4):1045-1058
pubmed: 31256132
Front Pharmacol. 2020 Jun 30;11:986
pubmed: 32695005
Endocrinology. 2014 Jan;155(1):89-97
pubmed: 24174323
Int Rev Neurobiol. 2015;124:3-19
pubmed: 26472524
J Med Chem. 1999 Jun 17;42(12):2251-9
pubmed: 10377231
J Exp Med. 2020 Jan 6;217(1):
pubmed: 31611248
PLoS One. 2013;8(4):e59586
pubmed: 23560052
Science. 2011 Oct 7;334(6052):98-101
pubmed: 21921156
J Nucl Med. 2004 May;45(5):878-84
pubmed: 15136639
Science. 2011 Sep 9;333(6048):1456-8
pubmed: 21778362
FASEB J. 2021 Jun;35(6):e21658
pubmed: 34010470
Int J Mol Sci. 2018 Sep 11;19(9):
pubmed: 30208620
Cells. 2020 Aug 21;9(9):
pubmed: 32839410
Behav Brain Res. 2016 Jan 1;296:270-278
pubmed: 26386305
Biochem Pharmacol. 2007 Oct 15;74(8):1212-23
pubmed: 17689498
Cell. 2017 Jun 15;169(7):1276-1290.e17
pubmed: 28602351
Prog Neurobiol. 2021 Nov;206:102154
pubmed: 34453977
Eur J Nucl Med Mol Imaging. 2003 Dec;30(12):1620-9
pubmed: 14523584
J Neuroinflammation. 2021 Apr 26;18(1):99
pubmed: 33902624
Neurosci Lett. 2020 Jul 13;731:135118
pubmed: 32502508
Front Aging Neurosci. 2018 Oct 08;10:314
pubmed: 30349474
J Neurosci. 2021 Oct 13;41(41):8461-8474
pubmed: 34446574
J Neuroendocrinol. 2018 Feb;30(2):
pubmed: 28667781
Cell. 2010 Mar 19;140(6):821-32
pubmed: 20303873
Neurobiol Aging. 2013 Jan;34(1):128-36
pubmed: 22840559
Cell. 2018 May 17;173(5):1073-1081
pubmed: 29775591
Nat Med. 2020 Jan;26(1):131-142
pubmed: 31932797
J Biol Chem. 2016 Jan 22;291(4):1591-1603
pubmed: 26627829
Nature. 2019 Nov;575(7784):669-673
pubmed: 31748742
EMBO Mol Med. 2016 Jun 01;8(6):595-608
pubmed: 27025652
Trends Pharmacol Sci. 2006 Aug;27(8):402-9
pubmed: 16822554
Cell. 2015 Dec 17;163(7):1730-41
pubmed: 26686654
Neuropathol Appl Neurobiol. 2009 Jun;35(3):306-28
pubmed: 19077109
J Biol Chem. 2014 Oct 3;289(40):27444-54
pubmed: 24936060
J Cereb Blood Flow Metab. 2015 May;35(5):766-72
pubmed: 25649991
Immunity. 2019 Jan 15;50(1):253-271.e6
pubmed: 30471926
J Alzheimers Dis. 2021;83(3):939-961
pubmed: 34366341
Neurotherapeutics. 2007 Jul;4(3):443-52
pubmed: 17599710
Eur J Nucl Med Mol Imaging. 2009 May;36(5):791-800
pubmed: 19137292
Acta Neuropathol. 2019 Apr;137(4):599-617
pubmed: 30721409
Theranostics. 2018 Oct 27;8(19):5400-5418
pubmed: 30555554
Brain. 2015 Dec;138(Pt 12):3685-98
pubmed: 26510952
Cell. 2013 Dec 19;155(7):1596-609
pubmed: 24360280
Front Immunol. 2019 May 09;10:1063
pubmed: 31143190
J Med Chem. 2013 Oct 10;56(19):7574-89
pubmed: 24050653
Hum Mol Genet. 2007 Dec 1;16(23):2921-32
pubmed: 17884806
Nature. 2013 Jan 31;493(7434):674-8
pubmed: 23254930
J Neuroinflammation. 2004 Jul 30;1(1):14
pubmed: 15285801
Neurosci Lett. 1986 Dec 3;72(1):115-9
pubmed: 3808458
J Cereb Blood Flow Metab. 2010 Sep;30(9):1608-18
pubmed: 20424634
Nature. 2019 Jun;570(7761):332-337
pubmed: 31042697
Bioorg Med Chem. 2013 May 1;21(9):2635-42
pubmed: 23507153
Proc Natl Acad Sci U S A. 1977 Sep;74(9):3805-9
pubmed: 20632
Cell Mol Neurobiol. 2021 Mar;41(2):377-393
pubmed: 33215356
Neurobiol Aging. 2018 Feb;62:197-209
pubmed: 29175709
J Neurosci. 2003 Mar 1;23(5):1605-11
pubmed: 12629164
Neurotherapeutics. 2020 Apr;17(2):676-689
pubmed: 31823156
J Neurochem. 2004 Apr;89(2):337-43
pubmed: 15056277
J Neurosci. 2019 Jul 24;39(30):5986-6000
pubmed: 31127002
Brain Res. 1994 May 2;644(2):181-7
pubmed: 7519524
Ann Nucl Med. 2002 May;16(3):189-200
pubmed: 12126044
Science. 2016 May 6;352(6286):712-716
pubmed: 27033548
Eur J Pharmacol. 2021 Nov 5;910:174506
pubmed: 34534533
Mol Med Rep. 2020 Aug;22(2):1053-1062
pubmed: 32468026
Nat Neurosci. 2019 Dec;22(12):2087-2097
pubmed: 31768052
Neuron. 2014 Apr 16;82(2):380-97
pubmed: 24742461
J Cereb Blood Flow Metab. 2017 Aug;37(8):2679-2690
pubmed: 28530125
Nat Rev Neurosci. 2014 Feb;15(2):84-97
pubmed: 24399084
Behav Brain Res. 2021 Jul 9;409:113338
pubmed: 33940049
Neurobiol Aging. 2013 Dec;34(12):2715-25
pubmed: 23831373
Bioorg Med Chem. 2019 Sep 15;27(18):4200-4210
pubmed: 31401009
Sci Rep. 2019 Apr 24;9(1):6475
pubmed: 31019207
Mol Med Rep. 2020 Sep;22(3):2063-2075
pubmed: 32582986
Lancet Neurol. 2013 Feb;12(2):207-16
pubmed: 23332364
J Biol Chem. 2021 Jan-Jun;296:100402
pubmed: 33571523
Acta Pharmacol Sin. 2019 Jun;40(6):737-745
pubmed: 30333556
Neuropharmacology. 1999 May;38(5):679-90
pubmed: 10340305
Nat Med. 2008 Aug;14(8):837-42
pubmed: 18568035
Molecules. 2020 Mar 20;25(6):
pubmed: 32245032
Eur J Neurosci. 2005 Sep;22(6):1349-56
pubmed: 16190890
Acta Neuropathol. 2018 Apr;135(4):529-550
pubmed: 29302779
J Biol Chem. 2001 Apr 27;276(17):13541-6
pubmed: 11278378
Neuroimage. 2016 Nov 1;141:71-80
pubmed: 27426839
Ann Neurol. 1997 Aug;42(2):159-63
pubmed: 9266724
Nature. 2016 Jul 06;535(7610):153-8
pubmed: 27383986
Nat Immunol. 2008 Aug;9(8):857-65
pubmed: 18604209
J Neurosci. 2009 Apr 1;29(13):3974-80
pubmed: 19339593
Neuron. 2016 May 18;90(4):853-65
pubmed: 27161528
Acta Neuropathol Commun. 2015 May 23;3:31
pubmed: 26001565
J Nucl Med. 2014 Nov;55(11):1885-92
pubmed: 25286922
Neurobiol Dis. 2019 Jan;121:95-105
pubmed: 30261283
J Inflamm (Lond). 2018 Nov 16;15:23
pubmed: 30473634
J Med Chem. 1998 Sep 10;41(19):3690-8
pubmed: 9733494
Steroids. 2003 Sep;68(7-8):569-85
pubmed: 12957662
Brain Res Brain Res Rev. 2005 Apr;48(2):234-9
pubmed: 15850662
EMBO Mol Med. 2019 Jun;11(6):
pubmed: 31015277
J Nucl Med. 2013 Aug;54(8):1308-14
pubmed: 23801676
J Neurochem. 1986 Jan;46(1):288-93
pubmed: 3940287
J Nucl Med. 2012 Jan;53(1):121-9
pubmed: 22173841
Neurology. 1998 Sep;51(3):728-33
pubmed: 9748017
J Biol Chem. 2010 Dec 17;285(51):40180-91
pubmed: 20947502
Nat Commun. 2014 Nov 19;5:5452
pubmed: 25406832
Int J Mol Sci. 2022 Jan 06;23(2):
pubmed: 35054805
Front Neurol. 2020 Sep 18;11:570711
pubmed: 33071950
Annu Rev Neurosci. 2002;25:103-26
pubmed: 12052905
Ann Neurol. 2010 Jan;67(1):114-21
pubmed: 20186856
Neuron. 2006 Nov 9;52(3):403-7
pubmed: 17088207
Molecules. 2021 Oct 11;26(20):
pubmed: 34684720
Cell Rep. 2018 Jan 16;22(3):832-847
pubmed: 29346778
J Biol Chem. 2014 May 16;289(20):13769-81
pubmed: 24692541
Pharmacol Ther. 1997;74(1):21-5
pubmed: 9336013
J Neuroinflammation. 2021 May 11;18(1):112
pubmed: 33975617
J Alzheimers Dis. 2014;40(4):1017-27
pubmed: 24577456
Biochem Biophys Res Commun. 1984 May 16;120(3):885-90
pubmed: 6375662
J Nucl Med. 2011 Jan;52(1):24-32
pubmed: 21149489
Neuromolecular Med. 2014 Mar;16(1):205-15
pubmed: 24197756
Neuroimage. 2010 Feb 15;49(4):2924-32
pubmed: 19948230
Nat Immunol. 2014 Aug;15(8):727-37
pubmed: 24952505
Acta Neuropathol. 2019 Mar;137(3):397-412
pubmed: 30599077
Psychopharmacology (Berl). 2010 Sep;212(1):1-12
pubmed: 20614106
Nucl Med Biol. 2013 Aug;40(6):731-9
pubmed: 23680470
Mol Neurobiol. 2021 May;58(5):2322-2341
pubmed: 33417228
Ann Neurol. 1981 Aug;10(2):122-6
pubmed: 7283399
Neurochem Int. 2018 Nov;120:238-250
pubmed: 30217465
Mol Neurobiol. 2020 Nov;57(11):4467-4487
pubmed: 32743737
J Exp Med. 2019 Jan 7;216(1):60-70
pubmed: 30504438
Cell. 2007 Dec 14;131(6):1164-78
pubmed: 18083105
Front Mol Neurosci. 2020 Jun 03;13:94
pubmed: 32581707
Nat Med. 2018 Jan;24(1):29-38
pubmed: 29200205
J Neurochem. 2000 Jan;74(1):237-43
pubmed: 10617125
Neuroimage. 2008 Mar 1;40(1):43-52
pubmed: 18093844
Front Aging Neurosci. 2019 Mar 13;11:56
pubmed: 30930767
Trends Endocrinol Metab. 2015 Jul;26(7):341-8
pubmed: 25801473
Psychoneuroendocrinology. 2019 Aug;106:65-76
pubmed: 30954920
Synapse. 2012 Apr;66(4):352-68
pubmed: 22169936
Alzheimers Dement. 2022 Apr;18(4):700-789
pubmed: 35289055
EJNMMI Res. 2017 Dec;7(1):59
pubmed: 28741281
Cell Rep. 2014 Sep 11;8(5):1271-9
pubmed: 25159150
Cell Res. 2015 Dec;25(12):1285-98
pubmed: 26611636
J Nucl Med. 2015 May;56(5):701-6
pubmed: 25766898
Front Immunol. 2020 Mar 31;11:456
pubmed: 32296418
J Neuroinflammation. 2006 Mar 16;3:5
pubmed: 16542445
Ann Nucl Med. 2009 May;23(3):301-9
pubmed: 19337782
Am J Physiol Cell Physiol. 2004 May;286(5):C1100-8
pubmed: 15075209
Neuron. 2006 Feb 16;49(4):489-502
pubmed: 16476660
Cell Rep. 2017 Apr 25;19(4):688-696
pubmed: 28445721
Immunity. 2018 Feb 20;48(2):380-395.e6
pubmed: 29426702
EMBO J. 2002 Mar 1;21(5):1012-20
pubmed: 11867529
Int Immunopharmacol. 2021 Jul;96:107726
pubmed: 33975230
Nucl Med Biol. 2010 Apr;37(3):347-55
pubmed: 20346874
Nat Immunol. 2014 Aug;15(8):738-48
pubmed: 24952504
Bioorg Med Chem. 2019 Jun 1;27(11):2245-2252
pubmed: 31047775
Inflammopharmacology. 2019 Aug;27(4):663-677
pubmed: 30874945
Eur Neuropsychopharmacol. 2008 Mar;18(3):222-9
pubmed: 17728108
Nature. 2020 Jun;582(7813):571-576
pubmed: 32499656
Curr Neuropharmacol. 2013 May;11(3):298-314
pubmed: 24179465
Science. 2016 Aug 19;353(6301):777-83
pubmed: 27540165
Cell Res. 2008 Oct;18(10):997-1006
pubmed: 18766170
J Nucl Med. 1999 Aug;40(8):1374-80
pubmed: 10450691
J Nucl Med. 2011 Sep;52(9):1449-56
pubmed: 21828113
Nat Commun. 2020 Oct 23;11(1):5370
pubmed: 33097708
FEBS Lett. 2007 Feb 6;581(3):475-8
pubmed: 17240371
Lancet Neurol. 2010 Jan;9(1):119-28
pubmed: 20083042
Neuroimage. 2011 Jun 1;56(3):1111-21
pubmed: 21320609
J Neuropathol Exp Neurol. 2006 Nov;65(11):1090-7
pubmed: 17086106
Nat Commun. 2020 Nov 30;11(1):6129
pubmed: 33257666
Brain Res. 1992 Nov 20;596(1-2):142-8
pubmed: 1467980
Mol Cell Endocrinol. 2010 Oct 7;327(1-2):1-12
pubmed: 20600583
Science. 2016 Aug 19;353(6301):aad8670
pubmed: 27338705
J Neuroinflammation. 2017 Sep 26;14(1):192
pubmed: 28950908
Cell Stem Cell. 2010 Oct 8;7(4):483-95
pubmed: 20887954
J Alzheimers Dis. 2020;77(3):1043-1056
pubmed: 32804124
J Integr Neurosci. 2019 Mar 30;18(1):51-56
pubmed: 31091848
PLoS One. 2016 Dec 1;11(12):e0167307
pubmed: 27907096
Science. 2018 Oct 12;362(6411):185-189
pubmed: 30309946
Cell. 2014 May 22;157(5):1013-22
pubmed: 24855941
PLoS One. 2019 Sep 19;14(9):e0222861
pubmed: 31536603
Nature. 2015 Oct 29;526(7575):660-5
pubmed: 26375003
Glia. 2017 Feb;65(2):375-387
pubmed: 27862351
J Neuroinflammation. 2018 Dec 12;15(1):342
pubmed: 30541566
Brain. 2018 Jun 1;141(6):1855-1870
pubmed: 29608645
Clin Exp Immunol. 2021 Dec;206(3):282-300
pubmed: 34331705
Nat Commun. 2020 Jun 1;11(1):2709
pubmed: 32483169
Cell Rep. 2020 Feb 4;30(5):1271-1281
pubmed: 32023447
Neurobiol Aging. 2015 Sep;36(9):2483-500
pubmed: 26190634
Science. 2010 Dec 24;330(6012):1774
pubmed: 21148344
Exp Cell Res. 1999 Feb 1;246(2):443-50
pubmed: 9925760
J Neurochem. 1986 Dec;47(6):1948-54
pubmed: 3772387
Brain Res Bull. 2012 Jan 4;87(1):10-20
pubmed: 22024597
Nucl Med Biol. 2015 May;42(5):488-493
pubmed: 25687449
Lancet. 1976 Dec 25;2(8000):1403
pubmed: 63862
Mol Pharmacol. 1982 Jul;22(1):26-32
pubmed: 6289073
Eur J Nucl Med Mol Imaging. 2019 Oct;46(11):2329-2338
pubmed: 31363804
Cogn Process. 2012 May;13(2):93-110
pubmed: 22160349
Aging (Albany NY). 2020 Jan 30;12(2):1792-1807
pubmed: 32003755
Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12468-73
pubmed: 26385967
Pharmacol Rev. 2009 Mar;61(1):39-61
pubmed: 19293145
J Med Chem. 2008 Aug 14;51(15):4751-64
pubmed: 18605717
Brain Res. 2003 Jan 17;960(1-2):259-62
pubmed: 12505680
Aging (Albany NY). 2020 Jan 6;12(1):543-570
pubmed: 31905173
Chem Pharm Bull (Tokyo). 1992 Mar;40(3):734-6
pubmed: 1611685
Biochem Pharmacol. 2015 Oct 15;97(4):439-444
pubmed: 26212541
Neuron. 2016 Mar 2;89(5):948-55
pubmed: 26875622
Nature. 2019 Feb;566(7744):388-392
pubmed: 30760929
J Cereb Blood Flow Metab. 2012 Jan;32(1):1-5
pubmed: 22008728
Front Neurosci. 2019 May 15;13:472
pubmed: 31156366
Nucl Med Biol. 1998 Oct;25(7):599-603
pubmed: 9804040
Neuroimage. 2012 Oct 15;63(1):232-9
pubmed: 22776451
Brain Pathol. 2020 Jan;30(1):151-164
pubmed: 31276244
J Biol Chem. 1994 Mar 11;269(10):7527-31
pubmed: 8125973
Neuron. 2012 May 24;74(4):691-705
pubmed: 22632727
Int J Mol Sci. 2019 Jul 09;20(13):
pubmed: 31323920
J Cereb Blood Flow Metab. 2020 Jun;40(6):1242-1255
pubmed: 31242048
Biochem Pharmacol. 2021 Oct;192:114754
pubmed: 34480881
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3170-4
pubmed: 1373486
Nature. 2000 May 25;405(6785):458-62
pubmed: 10839541
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4734-9
pubmed: 11274373
Eur J Nucl Med Mol Imaging. 2017 Jun;44(6):1042-1050
pubmed: 28120003
Neural Regen Res. 2021 Jun;16(6):1099-1104
pubmed: 33269756
Ann Neurol. 2004 Mar;55(3):306-19
pubmed: 14991808
Mol Imaging Biol. 2014 Oct;16(5):730-8
pubmed: 25145965
Steroids. 1997 Jan;62(1):21-8
pubmed: 9029710
J Neural Transm (Vienna). 2010 Aug;117(8):919-47
pubmed: 20632195