Synthesis and Investigation of the G-Quadruplex Binding Properties of Kynurenic Acid Derivatives with a Dihydroimidazoquinoline-3,5-dione Core.
DNA
G-quadruplex
KYNA
cytotoxicity
kynurenic acid
stabilization
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
27 Apr 2022
27 Apr 2022
Historique:
received:
18
03
2022
revised:
21
04
2022
accepted:
25
04
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
20
5
2022
Statut:
epublish
Résumé
G-quadruplexes are secondary structures originating from nucleic acid regions rich in guanines, which are well known for their involvement in gene transcription and regulation and DNA damage repair. In recent studies from our group, kynurenic acid (KYNA) derivative
Identifiants
pubmed: 35566141
pii: molecules27092791
doi: 10.3390/molecules27092791
pmc: PMC9103425
pii:
doi:
Substances chimiques
DNA
9007-49-2
Kynurenic Acid
H030S2S85J
Nitrogen
N762921K75
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Universities and Research
ID : PRIN 2017 2017SA5837
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