Is Poor Lithium Response in Individuals with Bipolar Disorder Associated with Increased Degradation of Tryptophan along the Kynurenine Pathway? Results of an Exploratory Study.

Alda scale bipolar disorder indoleamine 2,3 dioxygenase (IDO) kynurenine lithium response tryptophan

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
29 Apr 2022
Historique:
received: 16 02 2022
revised: 15 04 2022
accepted: 27 04 2022
entrez: 14 5 2022
pubmed: 15 5 2022
medline: 15 5 2022
Statut: epublish

Résumé

Bipolar disorder is associated with an inflammation-triggered elevated catabolism of tryptophan to the kynurenine pathway, which impacts psychiatric symptoms and outcomes. The data indicate that lithium exerts anti-inflammatory effects by inhibiting indoleamine-2,3-dioxygenase (IDO)-1 activity. This exploratory study aimed to investigate the tryptophan catabolism in individuals with bipolar disorder (

Identifiants

pubmed: 35566641
pii: jcm11092517
doi: 10.3390/jcm11092517
pmc: PMC9103936
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Frederike T Fellendorf (FT)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09121 Cagliari, Italy.
Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8010 Graz, Austria.

Mirko Manchia (M)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09121 Cagliari, Italy.
Department of Pharmacology, Dalhousie University, Halifax, NS B3H 0A2, Canada.
Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09121 Cagliari, Italy.

Alessio Squassina (A)

Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.

Claudia Pisanu (C)

Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.

Stefano Dall'Acqua (S)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.

Stefania Sut (S)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.

Sofia Nasini (S)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.

Donatella Congiu (D)

Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.

Eva Z Reininghaus (EZ)

Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8010 Graz, Austria.

Mario Garzilli (M)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09121 Cagliari, Italy.
Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09121 Cagliari, Italy.

Beatrice Guiso (B)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09121 Cagliari, Italy.
Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09121 Cagliari, Italy.

Federico Suprani (F)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09121 Cagliari, Italy.
Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09121 Cagliari, Italy.

Pasquale Paribello (P)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09121 Cagliari, Italy.
Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09121 Cagliari, Italy.

Vittoria Pulcinelli (V)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09121 Cagliari, Italy.
Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09121 Cagliari, Italy.

Maria Novella Iaselli (MN)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09121 Cagliari, Italy.
Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09121 Cagliari, Italy.

Ilaria Pinna (I)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09121 Cagliari, Italy.
Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09121 Cagliari, Italy.

Giulia Somaini (G)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09121 Cagliari, Italy.
Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09121 Cagliari, Italy.

Laura Arru (L)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09121 Cagliari, Italy.
Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09121 Cagliari, Italy.

Carolina Corrias (C)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09121 Cagliari, Italy.
Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09121 Cagliari, Italy.

Federica Pinna (F)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09121 Cagliari, Italy.
Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09121 Cagliari, Italy.

Bernardo Carpiniello (B)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09121 Cagliari, Italy.
Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09121 Cagliari, Italy.

Stefano Comai (S)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.
San Raffaele Scientific Institute, 20132 Milano, Italy.
Department of Psychiatry, McGill University, Montreal, QC H3A 1A1, Canada.

Classifications MeSH