Antibodies towards TVLLPVIFF Amino Acid Sequence of TNF Receptor Induced by
Helicobacter pylori
antigenic mimicry
atherogenesis
human TNFR
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
01 May 2022
01 May 2022
Historique:
received:
14
02
2022
revised:
14
04
2022
accepted:
29
04
2022
entrez:
14
5
2022
pubmed:
15
5
2022
medline:
15
5
2022
Statut:
epublish
Résumé
Molecular mimicry between To examine whether anti-P1 IgG are induced during Hp infection in CHD patients. Sera from CHD patients infected with Hp (54) vs. sera of uninfected healthy donors (22) were tested by the ELISA for anti- Sera of 43 CHD patients seropositive for anti-Hp IgG contained anti-P1 IgG binding C1q. Additionally, 10 serum samples of animals seropositive for anti-Hp IgG contained anti-P1 IgG. Anti-P1 IgG in tested sera were neutralized by their adsorption with Hp. In CHD patients infected with Hp, antibodies cross-reacting with TNFR common sequence are produced. Further studies are necessary to define immunogenic Hp determinants and to confirm possible cellular effects of cross-reacting antibodies.
Sections du résumé
BACKGROUND
BACKGROUND
Molecular mimicry between
AIM
OBJECTIVE
To examine whether anti-P1 IgG are induced during Hp infection in CHD patients.
METHODS
METHODS
Sera from CHD patients infected with Hp (54) vs. sera of uninfected healthy donors (22) were tested by the ELISA for anti-
RESULTS
RESULTS
Sera of 43 CHD patients seropositive for anti-Hp IgG contained anti-P1 IgG binding C1q. Additionally, 10 serum samples of animals seropositive for anti-Hp IgG contained anti-P1 IgG. Anti-P1 IgG in tested sera were neutralized by their adsorption with Hp.
CONCLUSION
CONCLUSIONS
In CHD patients infected with Hp, antibodies cross-reacting with TNFR common sequence are produced. Further studies are necessary to define immunogenic Hp determinants and to confirm possible cellular effects of cross-reacting antibodies.
Identifiants
pubmed: 35566671
pii: jcm11092545
doi: 10.3390/jcm11092545
pmc: PMC9103578
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Vasc Health Risk Manag. 2012;6:455-61
pubmed: 22923995
Trends Mol Med. 2003 Dec;9(12):549-57
pubmed: 14659470
Microbiol Immunol. 1997;41(5):387-93
pubmed: 9194037
Curr Protein Pept Sci. 2012 Dec;13(8):789-806
pubmed: 23305365
J Autoimmun. 2018 Dec;95:100-123
pubmed: 30509385
Arch Med Sci. 2016 Feb 1;12(1):45-54
pubmed: 26925118
Int J Mol Sci. 2021 Mar 25;22(7):
pubmed: 33806236
Clin Sci (Lond). 2009 Feb;116(3):219-30
pubmed: 19118493
J Physiol Pharmacol. 2006 Sep;57 Suppl 3:101-11
pubmed: 17033109
PLoS One. 2019 Aug 7;14(8):e0220636
pubmed: 31390383
J Infect. 2004 Jul;49(1):8-12
pubmed: 15194241
Int J Mol Sci. 2020 Mar 05;21(5):
pubmed: 32151084
Int J Mol Sci. 2019 Sep 07;20(18):
pubmed: 31500313
J Immunol. 2003 Jan 15;170(2):667-71
pubmed: 12517926
Heart Fail Rev. 2011 Jan;16(1):49-69
pubmed: 20571888
J Mol Biol. 2009 Feb 13;386(1):204-17
pubmed: 19109970
Cell Commun Signal. 2013 Oct 07;11:77
pubmed: 24099599
Int J Gen Med. 2021 Apr 23;14:1533-1540
pubmed: 33935515
Clin Immunol Immunopathol. 1990 Jan;54(1):148-60
pubmed: 2293904
Lipids Health Dis. 2010 Aug 30;9:92
pubmed: 20804546
Br J Haematol. 2004 Jan;124(1):91-6
pubmed: 14675413
World J Cardiol. 2015 Apr 26;7(4):187-203
pubmed: 25914788
FEMS Immunol Med Microbiol. 2001 Mar;30(2):167-72
pubmed: 11267851
Acta Biochim Pol. 2015;62(4):697-706
pubmed: 26610308
Circulation. 2002 Jul 23;106(4):430-4
pubmed: 12135941
Pol J Microbiol. 2006;55(1):25-30
pubmed: 16878600
J Am Coll Cardiol. 2009 Dec 1;54(23):2129-38
pubmed: 19942084
Br Heart J. 1994 May;71(5):437-9
pubmed: 8011406
FEBS J. 2011 Apr;278(8):1203-12
pubmed: 21352490
Braz J Microbiol. 2022 Mar;53(1):33-50
pubmed: 34988937
Sci Rep. 2021 Feb 25;11(1):4584
pubmed: 33633144
Circulation. 2018 Sep 11;138(11):1130-1143
pubmed: 29588316
Helicobacter. 2007 Aug;12(4):298-305
pubmed: 17669101
Int J Rheum Dis. 2018 May;21(5):908-921
pubmed: 29671956
Stroke. 2001 Feb;32(2):385-91
pubmed: 11157171
Nature. 2002 Dec 19-26;420(6917):868-74
pubmed: 12490960
Heart. 1996 Jun;75(6):573-5
pubmed: 8697159
Helicobacter. 2019 Sep;24 Suppl 1:e12638
pubmed: 31486234
J Physiol Pharmacol. 1996 Sep;47(3):545-53
pubmed: 8877910
Dig Dis Sci. 2000 Jun;45(6):1227-32
pubmed: 10877241
Sci Rep. 2015 May 06;5:10024
pubmed: 25944120
Biochem Biophys Res Commun. 2021 Jun 4;556:192-198
pubmed: 33845309
J Neurol. 2011 May;258(5):753-61
pubmed: 21085982
Circ Res. 2018 Oct 26;123(10):1118-1120
pubmed: 30359201
APMIS. 2019 Mar;127(3):139-149
pubmed: 30746790
Semin Immunopathol. 2009 Jun;31(1):79-94
pubmed: 19415283
Heart. 2000 Sep;84(3):267-71
pubmed: 10956287
Cardiovasc Res. 2008 Aug 1;79(3):360-76
pubmed: 18487233
Eur J Intern Med. 2011 Apr;22(2):191-4
pubmed: 21402252