A novel longitudinal clustering approach to psychopathology across diagnostic entities in the hospital-based PsyCourse study.

Bipolar Disorder / diagnosis Cluster Analysis Hospitals Humans Mental Disorders / diagnosis Psychopathology
Bipolar disorder Cluster analysis Machine learning Psychopathology Schizophrenia

Journal

Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207

Informations de publication

Date de publication:
06 2022
Historique:
received: 16 11 2020
revised: 23 01 2022
accepted: 02 05 2022
pubmed: 15 5 2022
medline: 22 6 2022
entrez: 14 5 2022
Statut: ppublish

Résumé

Biological research and clinical management in psychiatry face two major impediments: the high degree of overlap in psychopathology between diagnoses and the inherent heterogeneity with regard to severity. Here, we aim to stratify cases into homogeneous transdiagnostic subgroups using psychometric information with the ultimate aim of identifying individuals with higher risk for severe illness. 397 participants of the PsyCourse study with schizophrenia- or bipolar-spectrum diagnoses were prospectively phenotyped over 18 months. Factor analysis of mixed data of different rating scales and subsequent longitudinal clustering were used to cluster disease trajectories. Five clusters of longitudinal trajectories were identified in the psychopathologic dimensions. Clusters differed significantly with regard to Global Assessment of Functioning, disease course, and-in some cases-diagnosis while there were no significant differences regarding sex, age at baseline or onset, duration of illness, or polygenic burden for schizophrenia. Longitudinal clustering may aid in identifying transdiagnostic homogeneous subgroups of individuals with severe psychiatric disease.

Identifiants

DOI: 10.1016/j.schres.2022.05.001 PMID: 35567871
pubmed: 35567871
pii: S0920-9964(22)00163-3
doi: 10.1016/j.schres.2022.05.001
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

29-38

Informations de copyright

Copyright © 2022. Published by Elsevier B.V.

Auteurs

Eva C Schulte (EC)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany. Electronic address: eva.schulte@med.uni-muenchen.de.

Ivan Kondofersky (I)

Institute of Computational Biology, Helmholtz Center Munich, Ingolstädter Landstr. 1, Oberschleissheim 85764, Germany; Department of Mathematics, Technische Universität München, Boltzmannstr 3, Garching 85748, Germany.

Monika Budde (M)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany.

Sergi Papiol (S)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany.

Fanny Senner (F)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany.

Sabrina K Schaupp (SK)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany.

Daniela Reich-Erkelenz (D)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany.

Farahnaz Klöhn-Saghatolislam (F)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany.

Janos L Kalman (JL)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany; International Max Planck Research School (IMPRS-TP), Max-Planck Institute of Psychiatry, Munich 80804, Germany.

Katrin Gade (K)

Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, von-Siebold-Str 5, Goettingen, 37075, Germany.

Maria Hake (M)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany.

Ashley L Comes (AL)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany; International Max Planck Research School (IMPRS-TP), Max-Planck Institute of Psychiatry, Munich 80804, Germany.

Heike Anderson-Schmidt (H)

Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, von-Siebold-Str 5, Goettingen, 37075, Germany.

Kristina Adorjan (K)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany.

Georg Juckel (G)

Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr University Bochum, Alexandrinenstr. 1-3, Bochum 44791, Germany.

Max Schmauß (M)

Clinic for Psychiatry, Psychotherapy and Psychosomatics, Bezirkskrankenhaus Augsburg, Augsburg University, Dr.-Mack-Str. 1, Augsburg 86156, Germany.

Jörg Zimmermann (J)

Karl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Hermann-Ehlers-Str. 7, Bad Zwischenahn 26160, Germany.

Jens Reimer (J)

Center for Psychosocial Medicine, Gesundheit Nord Klinikverbund Bremen, Züricher Str 40, Bremen 28325, Germany; Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Martinistr 52, Hamburg 20246, Germany.

Jens Wiltfang (J)

Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, von-Siebold-Str 5, Goettingen, 37075, Germany; German Center for Neurodegenerative Diseases (DZNE), von-Siebold-Str. 3a, Goettingen 37075, Germany; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Agra do Crasto, 3810-193 Aveiro, Portugal.

Eva Z Reininghaus (EZ)

Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Auenbruggerplatz 31, Graz 8036, Austria.

Ion-George Anghelescu (IG)

Clinic Pacelliallee, Pacelliallee 6, Berlin 14195, Germany.

Carsten Konrad (C)

Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Elise-Averdieck-Str. 17, Rotenburg 27356, Germany.

Christian Figge (C)

Karl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Hermann-Ehlers-Str. 7, Bad Zwischenahn 26160, Germany.

Martin von Hagen (M)

Clinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Elsa Branströmstrasse 1, Eschwege 37269, Germany.

Markus Jäger (M)

Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg 89312, Germany.

Detlef E Dietrich (DE)

AMEOS Clinical Center Hildesheim, Goslarsche Landstr 60, Hildesheim 31135, Germany; Center for Systems Neuroscience Hannover, Bünteweg 2, Hannover 30559, Germany; Burghof-Klinik Rinteln, Ritterstr. 9, Rinteln 31737, Germany.

Carsten Spitzer (C)

Department of Psychosomatics and Psychotherapeutic Medicine, University Medical Center Rostock, Gehlsheimer Str 20, Rostock 18147, Germany.

Stephanie H Witt (SH)

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, Mannheim 68159, Germany.

Andreas J Forstner (AJ)

Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Venusberg-Campus 1, Bonn 53127, Germany; Centre for Human Genetics, University of Marburg, Baldingerstr, Marburg 35033, Germany.

Marcella Rietschel (M)

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, Mannheim 68159, Germany.

Markus M Nöthen (MM)

Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Venusberg-Campus 1, Bonn 53127, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Venusberg-Campus 1, Bonn 53127, Germany.

Peter Falkai (P)

Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany.

Urs Heilbronner (U)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany.

Nikola S Mueller (NS)

Institute of Computational Biology, Helmholtz Center Munich, Ingolstädter Landstr. 1, Oberschleissheim 85764, Germany.

Thomas G Schulze (TG)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr 7, Munich 80336, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, von-Siebold-Str 5, Goettingen, 37075, Germany; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, Mannheim 68159, Germany; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, 1800 Orleans St, Baltimore, MD 21287, USA; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, |50 East Adams Street, Syracuse, NY 13210, USA.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Troubles bipolaires et apparentés › Trouble bipolaire › A novel longitudinal clustering approach to...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de regroupements › A novel longitudinal clustering approach to...
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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A novel longitudinal clustering approach to...
questionsmedicales.fr › Troubles mentaux › A novel longitudinal clustering approach to...
questionsmedicales.fr › Disciplines et activités comportementales › Sciences du comportement › Psychopathologie › A novel longitudinal clustering approach to...