Association between bone turnover markers and periodontitis: A population-based cross-sectional study.
Study of Health in Pomerania
bone remodelling
bone turnover marker
periodontitis
serum markers
Journal
Journal of clinical periodontology
ISSN: 1600-051X
Titre abrégé: J Clin Periodontol
Pays: United States
ID NLM: 0425123
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
26
04
2022
received:
04
03
2022
accepted:
06
05
2022
pubmed:
16
5
2022
medline:
22
6
2022
entrez:
15
5
2022
Statut:
ppublish
Résumé
To examine the associations between bone turnover markers and periodontitis in two cross-sectional population-based studies. We used data from two independent adult samples (N = 4993), collected within the Study of Health in Pomerania project, to analyse cross-sectional associations of N-procollagen type 1 amino-terminal propeptide (P1NP), C-terminal cross-linking telopeptide, osteocalcin, bone-specific alkaline phosphatase (BAP), fibroblast growth factor 23, wingless-type mouse mammary tumour virus integration site family member 5a (WNT5A), and sclerostin values with periodontitis. Confounder-adjusted gamma and fractional response regression models were applied. Positive associations were found for P1NP with mean pocket probing depth (PPD; This study revealed scattered associations of P1NP, BAP, WNT5A, and sclerostin with periodontitis, but the results are contradictory in the overall context. Associations reported in previous studies could not be confirmed.
Substances chimiques
Biomarkers
0
Collagen Type I
0
Alkaline Phosphatase
EC 3.1.3.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
633-641Informations de copyright
© 2022 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.
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