Positioning biologics in the treatment of IBD: A practical guide

Adalimumab Biological therapy Infliximab Monoclonal antibodies Ustekinumab Vedolizumab

Journal

Current research in pharmacology and drug discovery
ISSN: 2590-2571
Titre abrégé: Curr Res Pharmacol Drug Discov
Pays: Netherlands
ID NLM: 9918300982506676

Informations de publication

Date de publication:
2022
Historique:
received: 12 01 2022
revised: 04 04 2022
accepted: 24 04 2022
entrez: 16 5 2022
pubmed: 17 5 2022
medline: 17 5 2022
Statut: epublish

Résumé

The number of available biological therapies have doubled over the last 10 years and the arrival of novel molecules (interleukin 23p19 inhibitors) is ongoing alongside the development of small molecules. As a result of this vast landscape of treatment, positioning advanced therapies (according to clinical situation, efficacy and safety) is of paramount importance to providing personalized, appropriate IBD treatment. In this publication the recent available literature is summarized for practical integration into clinical practice including comparative efficacy data, patient and disease demographics. We refer to recent publications and expert opinion in order to facilitate the decision making process of positioning biologicals IBD treatment.

Identifiants

pubmed: 35570855
doi: 10.1016/j.crphar.2022.100104
pii: S2590-2571(22)00024-4
pmc: PMC9092374
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

100104

Informations de copyright

© 2022 The Authors. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Pascal Juillerat ​received consulting fees from AbbVie, Arena Pharma, Amgen, BMS, Ferring, Gilead, Janssen, Lilly, MSD, Pfizer, Pierre Fabre, Roche, Takeda, and Vifor Pharma. Lecture fees from AbbVie, Amgen, Janssen, Pfizer, Takeda, UCB pharma and Vifor Pharma and research grants from Vifor Pharma. ​Maude Martinho Grueber, Roseline Ruetsch, Giulia Santi and Marianne Vullièmoz ​have no conflict of interest to declare. ​Pierre Michetti ​received consulting fees from AstraZeneca, AbbVie, Ferring Pharmaceuticals, Janssen, MSD, Nestlé Health Sciences, Pfizer, Pierre Fabre, Takeda, UCB Pharma, and Vifor Pharma, lecture fees from Ferring Pharmaceuticals, Janssen, Hospira, MSD, Pfizer, Takeda, UCB Pharma, and Vifor Pharma and research grants from iQone.

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Auteurs

Pascal Juillerat (P)

Gastroenterology, Clinic for Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Crohn and Colitis Center, Gastro-entérologie Beaulieu SA, Lausanne, Switzerland.

Maude Martinho Grueber (MM)

Gastroenterology, Clinic for Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Crohn and Colitis Center, Gastro-entérologie Beaulieu SA, Lausanne, Switzerland.

Roseline Ruetsch (R)

Crohn and Colitis Center, Gastro-entérologie Beaulieu SA, Lausanne, Switzerland.

Giulia Santi (G)

Gastroenterology, Clinic for Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Marianne Vuillèmoz (M)

Crohn and Colitis Center, Gastro-entérologie Beaulieu SA, Lausanne, Switzerland.

Pierre Michetti (P)

Crohn and Colitis Center, Gastro-entérologie Beaulieu SA, Lausanne, Switzerland.
Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

Classifications MeSH