Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort.
CASMIN
CKD
biomarker
chronic kidney disease
educational attainment
socioeconomic status
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
12
12
2020
revised:
25
01
2022
accepted:
02
02
2022
entrez:
16
5
2022
pubmed:
17
5
2022
medline:
17
5
2022
Statut:
epublish
Résumé
Prospective data on impact of educational attainment on prognosis in patients with chronic kidney disease (CKD) are scarce. We investigated the association between educational attainment and all-cause mortality, major adverse cardiovascular (CV) events (MACEs), kidney failure requiring dialysis, and CKD etiology. Participants ( Participants with low educational attainment (vs. high) had a higher risk for mortality (hazard ratio [HR] 1.48, 95% CI: 1.16-1.90), MACE (HR 1.37, 95% CI: 1.02-1.83), and kidney failure (HR 1.54, 95% CI: 1.15-2.05). Mediators between low educational attainment and mortality were smoking, CV disease (CVD) at baseline, low income, higher body mass index, and higher serum levels of CRP, high-density lipoprotein cholesterol, uric acid, NGAL, BAP, NT-proBNP, OPN, H-FABP, and urea. Low educational attainment was positively associated with diabetic nephropathy (odds ratio [OR] 1.65, 95% CI: 1.36-2.0) and CKD subsequent to acute kidney injury (OR 1.56, 95% CI: 1.03-2.35), but negatively associated with IgA nephropathy (OR 0.68, 95% CI: 0.52-0.90). Low educational attainment is associated with adverse outcomes and CKD etiology. Lifestyle habits and biomarkers mediate associations between low educational attainment and mortality. Recognition of the role of educational attainment and the associated health-relevant risk factors is important to optimize the care of patients with CKD and improve prognosis.
Identifiants
pubmed: 35570994
doi: 10.1016/j.ekir.2022.02.001
pii: S2468-0249(22)01137-8
pmc: PMC9091575
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1004-1015Informations de copyright
© 2022 International Society of Nephrology. Published by Elsevier Inc.
Références
Am J Kidney Dis. 2008 Sep;52(3):595-605
pubmed: 18725016
J Health Care Poor Underserved. 2014 May;25(2):478-90
pubmed: 24858863
PLoS One. 2014 May 21;9(5):e94834
pubmed: 24847804
PLoS One. 2012;7(11):e50766
pubmed: 23226378
Osteoporos Int. 2012 May;23(5):1503-12
pubmed: 21811862
Kidney Int Suppl. 2005 Aug;(97):S62-7
pubmed: 16014103
Soc Sci Med. 2007 Aug;65(4):809-21
pubmed: 17499411
Biochim Biophys Acta Gene Regul Mech. 2020 Jun;1863(6):194418
pubmed: 31639475
Am J Kidney Dis. 2010 Jun;55(6):992-1000
pubmed: 20207457
Nephrol Dial Transplant. 2011 Dec;26(12):4017-23
pubmed: 21493815
J Am Soc Nephrol. 2017 Jul;28(7):2167-2179
pubmed: 28408440
Nephrol Dial Transplant. 2019 Aug 1;34(8):1361-1368
pubmed: 29897587
J Am Soc Nephrol. 2016 Jul;27(7):2135-47
pubmed: 26701975
Nephrol Dial Transplant. 2015 Mar;30(3):441-51
pubmed: 25271006
J Ren Nutr. 2020 Jul;30(4):296-304
pubmed: 31761711
Nephrol Dial Transplant. 2010 Oct;25(10):3222-30
pubmed: 20335273
J Epidemiol Community Health. 2018 Apr;72(4):270-279
pubmed: 29437863
Nutrients. 2018 Jan 10;10(1):
pubmed: 29320401
Cardiorenal Med. 2019;9(2):125-134
pubmed: 30726840
Am J Kidney Dis. 2016 Jan;67(1):31-9
pubmed: 26385817
Am J Prev Med. 2015 May;48(5):580-92
pubmed: 25891058
Sci Rep. 2019 Sep 27;9(1):13954
pubmed: 31562371
Am J Kidney Dis. 1994 Jan;23(1):16-22
pubmed: 8285192
Kidney Int Rep. 2017 Dec 23;3(3):610-618
pubmed: 29854968
Eur J Clin Nutr. 2021 Sep;75(9):1389-1397
pubmed: 33531632
Am J Kidney Dis. 2020 Aug;76(2):233-247
pubmed: 32387090
J Am Soc Nephrol. 2010 Nov;21(11):1979-85
pubmed: 20671215
PLoS One. 2012;7(3):e32619
pubmed: 22412897
Circ Heart Fail. 2014 Jan;7(1):35-42
pubmed: 24347663
Clin J Am Soc Nephrol. 2020 Mar 6;15(3):367-374
pubmed: 32079609
Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):613-622
pubmed: 30727754
BMJ Open. 2019 Sep 27;9(9):e030216
pubmed: 31562151
Nephrol Dial Transplant. 2020 Jul 1;35(7):1211-1218
pubmed: 30541108
BMC Med. 2014 Oct 21;12:182
pubmed: 25567363
ESC Heart Fail. 2019 Apr;6(2):416-427
pubmed: 30801997
PLoS One. 2016 Jul 06;11(7):e0158765
pubmed: 27383068
N Engl J Med. 2018 Jun 21;378(25):e34
pubmed: 29897866
J Bone Miner Res. 2008 Nov;23(11):1850-8
pubmed: 18597636
Nephrol Dial Transplant. 2012 Apr;27(4):1454-60
pubmed: 21862458
Clin Epidemiol. 2017 Jun 08;9:331-338
pubmed: 28652815
Kidney Int. 2014 Jan;85(1):198-203
pubmed: 24025641
Am J Prev Med. 2018 Feb;54(2):229-236
pubmed: 29241718
Clin J Am Soc Nephrol. 2011 Jul;6(7):1752-9
pubmed: 21597029
Clin Kidney J. 2017 Feb;10(1):49-54
pubmed: 28639628