Urinary Biomarkers of Oxidative Stress in Aging: Implications for Prediction of Accelerated Biological Age in Prospective Cohort Studies.

Adult Aged Aged, 80 and over Aging Biomarkers / urine Cross-Sectional Studies Deoxyguanosine / urine Humans Middle Aged Oxidative Stress Prospective Studies Young Adult

Journal

Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826

Informations de publication

Date de publication:
2022
Historique:
received: 28 10 2021
revised: 05 03 2022
accepted: 28 03 2022
entrez: 16 5 2022
pubmed: 17 5 2022
medline: 20 5 2022
Statut: epublish

Résumé

Aging is a major risk factor for a range of chronic diseases. Oxidative stress theory of aging has been previously proposed as one of the mechanisms responsible for the age-related decline in organ/tissue function and the development of age-related diseases. Urine contains rich biological information on the health status of every major organ system and can be an important noninvasive source for biomarkers of systemic oxidative stress in aging. The objective of this cross-sectional study was to validate a novel panel of urinary oxidative stress biomarkers. Nucleic acid oxidation adducts and oxidative damage markers of lipids and proteins were assessed in urine samples from nondiabetic and currently nonsmoking subjects ( Our findings showed that 8-oxo-7,8-deoxyguanosine (8-oxoG), 8-oxo-7,8-dihydroguanosine (8-OHdG), and dityrosine (DTyr) positively correlated with chronological age, while the level of an F Assessing urinary biomarkers of oxidative stress may be an important approach for the evaluation of biological age by identifying individuals at accelerated risk for the development of age-related diseases.

Sections du résumé

Background UNASSIGNED
Aging is a major risk factor for a range of chronic diseases. Oxidative stress theory of aging has been previously proposed as one of the mechanisms responsible for the age-related decline in organ/tissue function and the development of age-related diseases. Urine contains rich biological information on the health status of every major organ system and can be an important noninvasive source for biomarkers of systemic oxidative stress in aging.
Aims UNASSIGNED
The objective of this cross-sectional study was to validate a novel panel of urinary oxidative stress biomarkers.
Methods UNASSIGNED
Nucleic acid oxidation adducts and oxidative damage markers of lipids and proteins were assessed in urine samples from nondiabetic and currently nonsmoking subjects (
Results UNASSIGNED
Our findings showed that 8-oxo-7,8-deoxyguanosine (8-oxoG), 8-oxo-7,8-dihydroguanosine (8-OHdG), and dityrosine (DTyr) positively correlated with chronological age, while the level of an F
Conclusion UNASSIGNED
Assessing urinary biomarkers of oxidative stress may be an important approach for the evaluation of biological age by identifying individuals at accelerated risk for the development of age-related diseases.

Identifiants

DOI: 10.1155/2022/6110226 PMID: 35571254 PMC: PMC9106456
pubmed: 35571254
doi: 10.1155/2022/6110226
pmc: PMC9106456
doi:

Substances chimiques

Biomarkers 0
Deoxyguanosine G9481N71RO

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6110226

Subventions

Organisme : NIGMS NIH HHS
ID : U54 GM104938
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG068295
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG050911
Pays : United States
Organisme : Medical Research Council
ID : MR/S011676/1
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA255840
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103447
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG052363
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055395
Pays : United States
Organisme : Medical Research Council
ID : MR/R024227/1
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : P20 GM125528
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100782
Pays : United States

Informations de copyright

Copyright © 2022 Peter Mukli et al.

Déclaration de conflit d'intérêts

On behalf of all authors, the corresponding author states that there is no conflict of interest.

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Auteurs

Peter Mukli (P)

Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Department of Physiology, Semmelweis University, Budapest, Hungary.
ORCID: 0000-0003-4355-8103

Dee H Wu (DH)

Department of Radiological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
ORCID: 0000-0002-2737-813X

Tamas Csipo (T)

Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary.
ORCID: 0000-0003-2639-2404

Cameron D Owens (CD)

Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
ORCID: 0000-0002-5020-2810

Agnes Lipecz (A)

Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary.

Frigyes Samuel Racz (FS)

Department of Physiology, Semmelweis University, Budapest, Hungary.
Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, TX, USA.
ORCID: 0000-0001-9077-498X

Fouad A Zouein (FA)

The Cardiovascular, Renal, and Metabolic Diseases Research Center of Excellence, American University of Beirut Medical Center, Riad El-Solh, Beirut, Lebanon.
Department of Signaling and Cardiovascular Pathophysiology, UMR-S 1180, Inserm, Université Paris-Saclay, France.
Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
ORCID: 0000-0003-4451-804X

Adam Tabak (A)

International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary.
1st Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
ORCID: 0000-0002-6234-3936

Anna Csiszar (A)

Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Translational Medicine, Semmelweis University, Budapest, Hungary.
ORCID: 0000-0003-4842-6660

Zoltan Ungvari (Z)

Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Department of Radiological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary.
Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
ORCID: 0000-0002-6035-6039

Panayiotis D Tsitouras (PD)

Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
ORCID: 0000-0003-1418-4114

Andriy Yabluchanskiy (A)

Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
ORCID: 0000-0002-9648-7161

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questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Urinary Biomarkers of Oxidative Stress in...
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questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Nucléoside purique › Désoxyguanosine › Urinary Biomarkers of Oxidative Stress in...
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