Probiotic Mixture Containing
brain activity
emotional attention task (EAT)
functional connectivity
functional magnetic resonance imaging (fMRI)
gut microbiota
gut-brain axis
probiotics
task-related
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2022
2022
Historique:
received:
01
12
2021
accepted:
05
04
2022
entrez:
16
5
2022
pubmed:
17
5
2022
medline:
17
5
2022
Statut:
epublish
Résumé
Evidence from preclinical studies suggests that probiotics affect brain function The present proof-of-concept study investigated if a probiotic product containing a mixture of In this double-blinded, randomized, placebo-controlled crossover study (Clinicaltrials.gov, NCT03615651), 22 healthy subjects (24.2 ± 3.4 years, 6 males/16 females) were exposed to a probiotic intervention and a placebo for 4 weeks each, separated by a 4-week washout period. Subjects underwent functional magnetic resonance imaging while performing an emotional attention task after each intervention period. Differential brain activity and functional connectivity were assessed. Altered brain responses were observed in brain regions implicated in emotional, cognitive and face processing. Increased activation in the orbitofrontal cortex, a region that receives extensive sensory input and in turn projects to regions implicated in emotional processing, was found after probiotic intervention compared to placebo using a cluster-based analysis of functionally defined areas. Significantly reduced task-related functional connectivity was observed after the probiotic intervention compared to placebo. Fecal microbiota composition was not majorly affected by probiotic intervention. The probiotic intervention resulted in subtly altered brain activity and functional connectivity in healthy subjects performing an emotional task without major effects on the fecal microbiota composition. This indicates that the probiotic effects occurred [http://clinicaltrials.gov/], identifier [NCT03615651].
Sections du résumé
Background
UNASSIGNED
Evidence from preclinical studies suggests that probiotics affect brain function
Objective
UNASSIGNED
The present proof-of-concept study investigated if a probiotic product containing a mixture of
Design
UNASSIGNED
In this double-blinded, randomized, placebo-controlled crossover study (Clinicaltrials.gov, NCT03615651), 22 healthy subjects (24.2 ± 3.4 years, 6 males/16 females) were exposed to a probiotic intervention and a placebo for 4 weeks each, separated by a 4-week washout period. Subjects underwent functional magnetic resonance imaging while performing an emotional attention task after each intervention period. Differential brain activity and functional connectivity were assessed.
Results
UNASSIGNED
Altered brain responses were observed in brain regions implicated in emotional, cognitive and face processing. Increased activation in the orbitofrontal cortex, a region that receives extensive sensory input and in turn projects to regions implicated in emotional processing, was found after probiotic intervention compared to placebo using a cluster-based analysis of functionally defined areas. Significantly reduced task-related functional connectivity was observed after the probiotic intervention compared to placebo. Fecal microbiota composition was not majorly affected by probiotic intervention.
Conclusion
UNASSIGNED
The probiotic intervention resulted in subtly altered brain activity and functional connectivity in healthy subjects performing an emotional task without major effects on the fecal microbiota composition. This indicates that the probiotic effects occurred
Clinical Trial Registration
UNASSIGNED
[http://clinicaltrials.gov/], identifier [NCT03615651].
Identifiants
pubmed: 35571902
doi: 10.3389/fnut.2022.827182
pmc: PMC9104811
doi:
Banques de données
ClinicalTrials.gov
['NCT03615651']
Types de publication
Journal Article
Langues
eng
Pagination
827182Informations de copyright
Copyright © 2022 Rode, Edebol Carlman, König, Repsilber, Hutchinson, Thunberg, Andersson, Persson, Kiselev, Lathrop Stern, Salomon, Mohammed, Labus and Brummer.
Déclaration de conflit d'intérêts
LLS was employed by Pfizer Consumer Healthcare. This study received funding from Pfizer Consumer Healthcare. LLS was involved in study design and discussion of the results, but had no involvement in collection, analysis, interpretation of data or the decision to submit this article for publication. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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