Contributions of the Catechol-O-Methyltransferase Val158Met Polymorphism to Changes in Brain Iron Across Adulthood and Their Relationships to Working Memory.
COMT
QSM
SEM
ageing
brain iron
dopamine
longitudinal
working memory
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
12
2021
accepted:
16
03
2022
entrez:
16
5
2022
pubmed:
17
5
2022
medline:
17
5
2022
Statut:
epublish
Résumé
Ageing is associated with excessive free brain iron, which may induce oxidative stress and neuroinflammation, likely causing cognitive deficits. Lack of dopamine may be a factor behind the increase of iron with advancing age, as it has an important role in cellular iron homoeostasis. We investigated the effect of
Identifiants
pubmed: 35571998
doi: 10.3389/fnhum.2022.838228
pmc: PMC9091601
doi:
Types de publication
Journal Article
Langues
eng
Pagination
838228Informations de copyright
Copyright © 2022 Gustavsson, Papenberg, Falahati, Laukka and Kalpouzos.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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