Post-translational Modifications of the p53 Protein and the Impact in Alzheimer's Disease: A Review of the Literature.
Alzheimer’s disease (AD)
TP53
p53
post translational modification (PTM)
review
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2022
2022
Historique:
received:
14
12
2021
accepted:
04
03
2022
entrez:
16
5
2022
pubmed:
17
5
2022
medline:
17
5
2022
Statut:
epublish
Résumé
Our understanding of Alzheimer's disease (AD) pathogenesis has developed with several hypotheses over the last 40 years, including the Amyloid and Tau hypotheses. More recently, the p53 protein, well-known as a genome guardian, has gained attention for its potential role in the early evolution of AD. This is due to the central involvement of p53's in the control of oxidative stress and potential involvement in the Amyloid and Tau pathways. p53 is commonly regulated by post-translational modifications (PTMs), which affect its conformation, increasing its capacity to adopt multiple structural and functional states, including those that can affect brain processes, thus contributing to AD development. The following review will explore the impact of p53 PTMs on its function and consequential involvement in AD pathogenesis. The greater understanding of the role of p53 in the pathogenesis of AD could result in more targeted therapies benefiting the many patients of this debilitating disease.
Identifiants
pubmed: 35572126
doi: 10.3389/fnagi.2022.835288
pmc: PMC9096077
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
835288Informations de copyright
Copyright © 2022 Clark, Kayed, Abate, Uberti, Kinnon and Piccirella.
Déclaration de conflit d'intérêts
JC, PK, and SP were employed by Diadem srl. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cell. 1979 May;17(1):43-52
pubmed: 222475
Nature. 1979 Mar 15;278(5701):261-3
pubmed: 218111
Acta Neuropathol Commun. 2020 Apr 29;8(1):61
pubmed: 32349792
Nature. 1992 Mar 19;356(6366):215-21
pubmed: 1552940
Neuroscience. 2015 Aug 27;302:103-11
pubmed: 25286385
Biochim Biophys Acta. 2007 Jun;1772(6):629-44
pubmed: 17451912
Glia. 2014 Apr;62(4):493-503
pubmed: 24446231
Mol Cell Biol. 2000 Nov;20(22):8458-67
pubmed: 11046142
Cell Death Differ. 2016 Sep 1;23(9):1515-28
pubmed: 27104929
Curr Neuropharmacol. 2017;15(6):926-935
pubmed: 28093977
J Pers Med. 2020 Dec 26;11(1):
pubmed: 33375220
Mol Cell. 2001 Dec;8(6):1243-54
pubmed: 11779500
J Neuropathol Exp Neurol. 2000 Oct;59(10):880-8
pubmed: 11079778
J Mol Cell Biol. 2019 Jul 19;11(7):564-577
pubmed: 31282934
Cell Death Dis. 2013 Feb 07;4:e484
pubmed: 23392172
Neurodegener Dis. 2008;5(3-4):209-11
pubmed: 18322392
J Neurochem. 2013 Jun;125(5):790-9
pubmed: 23330981
Mech Ageing Dev. 2020 Dec;192:111385
pubmed: 33129798
Aging Cell. 2014 Jun;13(3):449-56
pubmed: 24341977
PLoS One. 2013 Jul 05;8(7):e68361
pubmed: 23861893
J Alzheimers Dis. 2010;20(1):97-104
pubmed: 20164600
Curr Alzheimer Res. 2012 Jan;9(1):67-85
pubmed: 22329652
Alzheimers Dement (N Y). 2018 Sep 06;4:575-590
pubmed: 30406177
Aging Cell. 2007 Jun;6(3):337-50
pubmed: 17328689
J Biol Chem. 2007 Jan 19;282(3):1797-804
pubmed: 17098746
Nat Rev Mol Cell Biol. 2007 Apr;8(4):275-83
pubmed: 17380161
Neuron. 2013 Dec 18;80(6):1347-58
pubmed: 24360540
Oxid Med Cell Longev. 2013;2013:316523
pubmed: 23983897
J Clin Invest. 1996 Oct 1;98(7):1626-32
pubmed: 8833912
Int Rev Neurobiol. 2020;154:131-151
pubmed: 32739002
J Alzheimers Dis. 2007 Aug;12(1):93-9
pubmed: 17851197
Aging Cell. 2010 Apr;9(2):174-90
pubmed: 20409077
Cell. 2004 Jul 9;118(1):83-97
pubmed: 15242646
Brain Res Bull. 2004 Mar 15;63(2):133-42
pubmed: 15130702
Front Endocrinol (Lausanne). 2019 Mar 12;10:152
pubmed: 30915036
Neurology. 2018 Oct 2;91(14):e1295-e1306
pubmed: 30217935
Alzheimers Res Ther. 2020 Dec 3;12(1):160
pubmed: 33272326
Redox Biol. 2018 Apr;14:450-464
pubmed: 29080524
Sci Rep. 2016 May 09;6:25628
pubmed: 27156849
Nat Rev Mol Cell Biol. 2008 May;9(5):402-12
pubmed: 18431400
Acta Neuropathol Commun. 2013 May 08;1:3
pubmed: 24252508
N Engl J Med. 2010 Jan 28;362(4):329-44
pubmed: 20107219
Mol Neurodegener. 2019 Jun 11;14(1):23
pubmed: 31186026
J Neurol Sci. 1998 Jun 11;158(1):47-52
pubmed: 9667777
Sci Transl Med. 2014 Mar 5;6(226):226ra30
pubmed: 24598588
Antioxid Redox Signal. 2014 Aug 1;21(4):533-50
pubmed: 24294978
Neuropharmacology. 2019 Mar 1;146:19-27
pubmed: 30452955
Nature. 2009 Oct 22;461(7267):1071-8
pubmed: 19847258
Free Radic Biol Med. 2010 May 15;48(10):1338-46
pubmed: 20171273
PLoS One. 2010 Apr 14;5(4):e10171
pubmed: 20418953
Prog Neurobiol. 2018 Sep;168:104-127
pubmed: 29733887
Nature. 2004 Nov 18;432(7015):353-60
pubmed: 15525938
Cancer Res. 2008 May 15;68(10):3707-14
pubmed: 18483253
Biochem Biophys Res Commun. 2006 Nov 24;350(3):530-6
pubmed: 17026966
Genes Cancer. 2011 Apr;2(4):443-52
pubmed: 21779512
Cell. 2017 Sep 7;170(6):1062-1078
pubmed: 28886379
Oncogene. 2007 Feb 26;26(9):1306-16
pubmed: 17322916
FASEB J. 2006 Jun;20(8):1212-4
pubmed: 16627626
Mol Oncol. 2016 Aug;10(7):1008-29
pubmed: 27118659
Curr Alzheimer Res. 2018;15(3):283-300
pubmed: 28413986
Int J Biol Macromol. 2021 Mar 1;172:93-103
pubmed: 33440210
J Alzheimers Dis. 2013;33 Suppl 1:S277-81
pubmed: 22635102
Hum Mol Genet. 2008 Mar 15;17(6):906-17
pubmed: 18065497
Curr Alzheimer Res. 2012 Dec;9(10):1191-7
pubmed: 22746246
J Biol Chem. 2009 Feb 20;284(8):5158-64
pubmed: 19106109
Epigenetics. 2009 Oct 1;4(7):445-51
pubmed: 19838051
Cell Death Differ. 2010 Jan;17(1):86-92
pubmed: 19543236
Nat Rev Mol Cell Biol. 2005 Feb;6(2):150-66
pubmed: 15688001
Cell. 1994 Jun 17;77(6):817-27
pubmed: 8004671
Trends Pharmacol Sci. 2008 Dec;29(12):609-15
pubmed: 18838179
J Neurochem. 2004 Jun;89(5):1308-12
pubmed: 15147524
Exp Neurol. 1998 Mar;150(1):40-4
pubmed: 9514828
Nat Cell Biol. 2008 Dec;10(12):1431-9
pubmed: 19011621
Oncogene. 2010 Aug 5;29(31):4378-87
pubmed: 20514025
Cell. 2004 Dec 17;119(6):847-60
pubmed: 15607980
Cell Death Differ. 2018 Jan;25(1):169-179
pubmed: 29192902
Cell. 1997 Oct 31;91(3):325-34
pubmed: 9363941
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8204-9
pubmed: 15928081
Free Radic Biol Med. 2008 Jul 1;45(1):1-17
pubmed: 18423411
Protein Cell. 2011 Jun;2(6):456-62
pubmed: 21748595
FEBS Lett. 2011 Sep 16;585(18):2803-9
pubmed: 21624367
Neurobiol Aging. 2004 Jul;25(6):713-8; discussion 743-6
pubmed: 15165692
Genes Dev. 1993 Jul;7(7A):1126-32
pubmed: 8319905
Biochem Pharmacol. 2000 Jan 1;59(1):25-33
pubmed: 10605931
J Neurochem. 2007 Oct;103(1):322-33
pubmed: 17608641
J Cell Sci. 2002 Aug 1;115(Pt 15):3131-8
pubmed: 12118068
FEBS J. 2005 Aug;272(16):4211-20
pubmed: 16098202
Oncogene. 2001 May 10;20(21):2611-7
pubmed: 11420672
PLoS One. 2012;7(1):e29789
pubmed: 22242180
Neuroscience. 2008 Apr 22;153(1):120-30
pubmed: 18353561
Neurosci Lett. 2010 Jan 14;468(3):320-5
pubmed: 19914341
Aging (Albany NY). 2010 Sep;2(9):545-54
pubmed: 20876941
Neurotox Res. 2000 Feb;1(3):197-233
pubmed: 12835102
Commun Biol. 2020 May 19;3(1):245
pubmed: 32427887
J Neurol Sci. 1996 Nov;143(1-2):137-42
pubmed: 8981312
Biochim Biophys Acta Rev Cancer. 2018 Aug;1870(1):32-42
pubmed: 29883595
Exp Cell Res. 2009 Jan 1;315(1):67-75
pubmed: 18996371
Nat Med. 2005 Dec;11(12):1306-13
pubmed: 16286925
Front Cell Neurosci. 2018 Jul 25;12:196
pubmed: 30090057
J Alzheimers Dis. 1999 Oct;1(3):139-145
pubmed: 12213999
Front Aging Neurosci. 2020 Sep 03;12:254
pubmed: 33088270
Signal Transduct Target Ther. 2020 Jun 10;5(1):90
pubmed: 32532965
Subcell Biochem. 2014;85:337-58
pubmed: 25201203
Nature. 1997 May 15;387(6630):296-9
pubmed: 9153395
Oncotarget. 2017 Oct 30;8(62):105222-105237
pubmed: 29285246
Mol Cell Biol. 2005 May;25(9):3737-51
pubmed: 15831478
Neurosci Lett. 2010 Jan 18;469(1):6-10
pubmed: 19914330
Neurobiol Aging. 2006 Sep;27(9):1193-201
pubmed: 16165254
Acta Neuropathol Commun. 2020 Aug 10;8(1):132
pubmed: 32778161
Mol Cell. 2005 Apr 29;18(3):283-93
pubmed: 15866171
Aging Cell. 2015 Aug;14(4):595-604
pubmed: 25773675