Morphological Analyses of Colorectal Adenocarcinomas in Japanese Familial Adenomatous Polyposis Patients.
colorectal cancer
colorectal neoplasm
depressed superficial lesion
familial adenomatous polyposis
morphology
non-polypoid colorectal neoplasm
Journal
Journal of the anus, rectum and colon
ISSN: 2432-3853
Titre abrégé: J Anus Rectum Colon
Pays: Japan
ID NLM: 101718055
Informations de publication
Date de publication:
2022
2022
Historique:
received:
05
07
2021
accepted:
15
11
2021
entrez:
16
5
2022
pubmed:
17
5
2022
medline:
17
5
2022
Statut:
epublish
Résumé
This retrospective study was conducted to clarify the morphological characteristics of colorectal cancer (CRC) in Japanese familial adenomatous polyposis (FAP) patients. This study was carried out by the study group for FAP of the Japanese Society for Cancer of the Colon and Rectum. FAP patients who underwent surgical resection between 2000 and 2012 were included in the study. Of the 303 patients enrolled, 119 patients without CRC were excluded. Of 523 lesions, 49 lesions with missing morphological information were excluded; hence, only 474 CRC lesions in 178 patients (328 superficial lesions in 122 patients and 146 non-superficial lesions in 92 patients) were included in the study. Depressed lesions accounted for 3.0% of superficial lesions and ulcerated lesions accounted for 84.9% of non-superficial lesions. The depressed superficial lesions were observed only in patients with sparse and attenuated FAP ( In patients with FAP, depressed superficial CRC lesions rarely developed but were detected in our study group, and ulcerated non-superficial CRC lesions were also present with similar ratios. Clinicians should pay attention to depressed superficial lesions during endoscopic surveillance of FAP patients.
Identifiants
pubmed: 35572485
doi: 10.23922/jarc.2021-047
pmc: PMC9045858
doi:
Types de publication
Journal Article
Langues
eng
Pagination
121-128Informations de copyright
Copyright © 2022 by The Japan Society of Coloproctology.
Déclaration de conflit d'intérêts
Conflicts of Interest There are no conflicts of interest.
Références
Ann Surg Oncol. 2016 Aug;23(Suppl 4):559-565
pubmed: 27387679
Nat Med. 2015 Nov;21(11):1350-6
pubmed: 26457759
Gut. 2006 Oct;55(10):1440-8
pubmed: 16461775
Dis Colon Rectum. 2002 Jan;45(1):127-34; discussion 134-6
pubmed: 11786778
Cell. 1991 Aug 9;66(3):589-600
pubmed: 1651174
Cell. 1991 Aug 9;66(3):601-13
pubmed: 1678319
Cancer. 1975 Dec;36(6):2251-70
pubmed: 1203876
Gastroenterology. 2020 Jan;158(2):291-302
pubmed: 31622622
J Anus Rectum Colon. 2019 Oct 30;3(4):175-195
pubmed: 31768468
Surg Today. 2017 Feb;47(2):233-237
pubmed: 27357052
Surg Today. 2017 Apr;47(4):470-475
pubmed: 27506752
Surg Today. 2017 Oct;47(10):1259-1267
pubmed: 28251376
Cancer Res. 1998 Mar 15;58(6):1130-4
pubmed: 9515795
Endoscopy. 2016 Jan;48(1):51-5
pubmed: 26352809
Jpn J Clin Oncol. 2016 Sep;46(9):819-24
pubmed: 27418167
Nihon Rinsho. 2014 Jan;72(1):143-9
pubmed: 24597363
Nature. 2002 Jun 27;417(6892):949-54
pubmed: 12068308
N Engl J Med. 1988 Sep 1;319(9):525-32
pubmed: 2841597
World J Surg. 2000 Sep;24(9):1081-90
pubmed: 11036286
Cancer Res. 1992 Jul 15;52(14):4055-7
pubmed: 1319838
Br J Surg. 1968 Oct;55(10):725-31
pubmed: 5681027
Gastroenterology. 2010 Jun;138(6):2088-100
pubmed: 20420948
Gut. 2020 Mar;69(3):411-444
pubmed: 31780574
Am J Gastroenterol. 2013 Jul;108(7):1042-56
pubmed: 23649184
ISRN Gastroenterol. 2013;2013:838134
pubmed: 23533795
Gastroenterology. 2019 Oct;157(4):949-966.e4
pubmed: 31323292
J Anus Rectum Colon. 2018 May 25;2(Suppl I):S1-S51
pubmed: 31773066