The Metabolic Basis of ILC Plasticity.
Innate Lymphoid Cells (ILCs)
OxPhos
cytokines
glycolysis
metabolism
plasticity
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
01
2022
accepted:
04
04
2022
entrez:
16
5
2022
pubmed:
17
5
2022
medline:
20
5
2022
Statut:
epublish
Résumé
Innate Lymphoid Cells (ILCs) are the innate counterpart of adaptive lymphoid T cells. They are key players in the regulation of tissues homeostasis and early inflammatory host responses. ILCs are divided into three groups, and further subdivided into five subsets, that are characterised by distinct transcription factors, surface markers and their cytokine expression profiles. Group 1 ILCs, including natural killer (NK) cells and non-NK cell ILC1s, express T-bet and produce IFN-γ. Group 2 ILCs depend on GATA3 and produce IL-4, IL-5 and IL-13. Group 3 ILCs, composed of ILC3s and Lymphoid Tissue Inducer (LTi) cells, express RORγt and produce IL-17 and IL-22. Even though, the phenotype of each subset is well defined, environmental signals can trigger the interconversion of phenotypes and the plasticity of ILCs, in both mice and humans. Several extrinsic and intrinsic drivers of ILC plasticity have been described. However, the changes in cellular metabolism that underlie ILC plasticity remain largely unexplored. Given that metabolic changes critically affect fate and effector function of several immune cell types, we, here, review recent findings on ILC metabolism and discuss the implications for ILC plasticity.
Identifiants
pubmed: 35572512
doi: 10.3389/fimmu.2022.858051
pmc: PMC9099248
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
858051Informations de copyright
Copyright © 2022 Pelletier and Stockmann.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Eur J Immunol. 2018 Jul;48(7):1174-1180
pubmed: 29524223
Cell Mol Immunol. 2019 Jul;16(7):634-643
pubmed: 30867582
Nature. 2010 Jan 28;463(7280):540-4
pubmed: 20023630
Nat Rev Immunol. 2014 Mar;14(3):181-94
pubmed: 24566915
J Exp Med. 2013 Jun 3;210(6):1117-24
pubmed: 23690441
Nat Immunol. 2017 Sep;18(9):1004-1015
pubmed: 28759001
Immunity. 2015 Jul 21;43(1):146-60
pubmed: 26187413
Nature. 2010 Apr 29;464(7293):1367-70
pubmed: 20200518
Immunity. 2010 Nov 24;33(5):736-51
pubmed: 21093318
J Immunol. 2016 Mar 15;196(6):2552-60
pubmed: 26873994
Nat Rev Immunol. 2016 Mar;16(3):149-63
pubmed: 26875830
Nat Rev Immunol. 2020 Sep;20(9):552-565
pubmed: 32107466
J Exp Med. 2020 Jan 6;217(1):
pubmed: 31570496
Nat Immunol. 2011 Jan;12(1):21-7
pubmed: 21113163
Front Immunol. 2017 Apr 03;8:367
pubmed: 28421073
J Exp Med. 2009 Aug 3;206(8):1643-6
pubmed: 19635860
J Immunother Cancer. 2021 Feb;9(2):
pubmed: 33568351
Nat Immunol. 2010 Nov;11(11):1030-8
pubmed: 20935648
Eur J Immunol. 2019 Sep;49(9):1344-1355
pubmed: 31151137
Crit Rev Immunol. 2016;36(2):131-147
pubmed: 27910764
J Biol Chem. 2016 Jun 17;291(25):12960-77
pubmed: 27129235
J Allergy Clin Immunol. 2020 Feb;145(2):502-517.e5
pubmed: 31738991
Nat Rev Immunol. 2013 Feb;13(2):145-9
pubmed: 23348417
Cell. 2018 Aug 23;174(5):1054-1066
pubmed: 30142344
Nat Immunol. 2021 Nov;22(11):1367-1374
pubmed: 34686862
Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5510-4
pubmed: 7539918
Immunity. 2014 Jan 16;40(1):66-77
pubmed: 24412613
J Exp Med. 2016 Jul 25;213(8):1409-18
pubmed: 27432938
Bone Res. 2018 Jan 31;6:2
pubmed: 29423331
Elife. 2019 Aug 08;8:
pubmed: 31393266
Front Immunol. 2019 Sep 11;10:2180
pubmed: 31572388
Mol Cell. 2008 May 23;30(4):393-402
pubmed: 18498744
Nat Commun. 2019 May 14;10(1):2162
pubmed: 31089134
Immunol Lett. 2016 Nov;179:9-18
pubmed: 27394700
Nat Rev Immunol. 2012 Mar 22;12(4):239-52
pubmed: 22437937
Nat Immunol. 2016 Jun;17(6):626-35
pubmed: 27111143
J Immunol. 2020 Sep 15;205(6):1608-1619
pubmed: 32817333
Nat Immunol. 2014 Aug;15(8):749-757
pubmed: 24973821
J Allergy Clin Immunol. 2019 Jan;143(1):229-244.e9
pubmed: 29625134
Immunity. 2019 Jul 16;51(1):185-197.e6
pubmed: 31278058
Nat Immunol. 2013 Apr;14(4):389-95
pubmed: 23455676
Mucosal Immunol. 2021 Jul;14(4):828-841
pubmed: 33446906
J Biol Chem. 2006 Apr 7;281(14):9030-7
pubmed: 16452478
Nat Immunol. 2016 Jun;17(6):656-65
pubmed: 27043409
J Immunol. 2016 Jun 15;196(12):5148-55
pubmed: 27183576
J Exp Med. 2016 Apr 4;213(4):569-83
pubmed: 26976630
Genes Dev. 1998 Jan 15;12(2):149-62
pubmed: 9436976
Int Immunol. 2016 Jan;28(1):35-42
pubmed: 26374472
Nat Immunol. 2019 Aug;20(8):980-991
pubmed: 31209406
Science. 1985 Nov 15;230(4727):758-66
pubmed: 2414846
Nat Immunol. 2014 Oct;15(10):957-64
pubmed: 25194422
Immunity. 2020 Jun 16;52(6):1075-1087.e8
pubmed: 32445619
Cell. 2012 Feb 3;148(3):399-408
pubmed: 22304911
J Immunol. 2015 Feb 15;194(4):1954-62
pubmed: 25595780
Nat Commun. 2017 Nov 17;8(1):1597
pubmed: 29150606
Front Oncol. 2019 Dec 13;9:1373
pubmed: 31921637
J Exp Med. 1999 Jan 18;189(2):231-9
pubmed: 9892606
Nature. 2009 Feb 5;457(7230):722-5
pubmed: 18978771
Science. 2014 Jan 24;343(6169):432-7
pubmed: 24458645
Nat Commun. 2018 Jun 14;9(1):2341
pubmed: 29904050
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11489-94
pubmed: 20534524
J Exp Med. 2022 Feb 7;219(2):
pubmed: 35024767
Front Immunol. 2019 Dec 13;10:2915
pubmed: 31921174
Blood Adv. 2017 Dec 14;1(27):2679-2691
pubmed: 29296921
Nature. 2013 Feb 14;494(7436):261-5
pubmed: 23334414
J Appl Physiol (1985). 2017 Nov 1;123(5):1328-1334
pubmed: 28408694
J Immunol. 2018 Jun 15;200(12):3934-3941
pubmed: 29720425
Nat Immunol. 2017 Sep;18(9):995-1003
pubmed: 28759002
Cell. 2016 Aug 25;166(5):1231-1246.e13
pubmed: 27545347
Nat Immunol. 2017 Nov;18(11):1197-1206
pubmed: 28920951
Nat Immunol. 2016 Jun 21;17(7):758-64
pubmed: 27328005
Cell Metab. 2006 Mar;3(3):177-85
pubmed: 16517405
J Exp Med. 2019 Oct 7;216(10):2231-2241
pubmed: 31296736
Nature. 2014 Apr 3;508(7494):123-7
pubmed: 24670648
Sci Signal. 2016 Feb 16;9(415):ra19
pubmed: 26884601
Nat Immunol. 2019 Aug;20(8):992-1003
pubmed: 31263279
Annu Rev Immunol. 2006;24:99-146
pubmed: 16551245
Immunity. 2018 Feb 20;48(2):258-270.e5
pubmed: 29452935
Blood. 2016 Sep 15;128(11):1475-89
pubmed: 27465917
Nat Immunol. 2016 Jun;17(6):636-45
pubmed: 27111145
Nat Immunol. 2009 Jan;10(1):66-74
pubmed: 19029905
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5667-72
pubmed: 9159130
J Immunol. 2014 Nov 1;193(9):4477-84
pubmed: 25261477
Trends Immunol. 2020 Oct;41(10):902-917
pubmed: 32917510