Synaptic Vesicle Glycoprotein 2A: Features and Functions.
UCB-J
levetiracetam
neuroimaging
positron emission tomography (PET)
synaptic density
synaptic vesicle glycoprotein 2A (SV2A)
synaptic vesicles
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2022
2022
Historique:
received:
28
01
2022
accepted:
05
04
2022
entrez:
16
5
2022
pubmed:
17
5
2022
medline:
17
5
2022
Statut:
epublish
Résumé
In recent years, the field of neuroimaging dramatically moved forward by means of the expeditious development of specific radioligands of novel targets. Among these targets, the synaptic vesicle glycoprotein 2A (SV2A) is a transmembrane protein of synaptic vesicles, present in all synaptic terminals, irrespective of neurotransmitter content. It is involved in key functions of neurons, focused on the regulation of neurotransmitter release. The ubiquitous expression in gray matter regions of the brain is the basis of its candidacy as a marker of synaptic density. Following the development of molecules derived from the structure of the anti-epileptic drug levetiracetam, which selectively binds to SV2A, several radiolabeled markers have been synthetized to allow the study of SV2A distribution with positron emission tomography (PET). These radioligands permit the evaluation of
Identifiants
pubmed: 35573314
doi: 10.3389/fnins.2022.864514
pmc: PMC9096842
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
864514Informations de copyright
Copyright © 2022 Rossi, Arjmand, Bærentzen, Gjedde and Landau.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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