Reconstruction of the origin of the first major SARS-CoV-2 outbreak in Germany.
Outbreak
Phylogenetic analysis
SARS-CoV-2
Sequencing
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
2022
2022
Historique:
received:
11
03
2022
revised:
06
05
2022
accepted:
06
05
2022
pubmed:
17
5
2022
medline:
17
5
2022
entrez:
16
5
2022
Statut:
ppublish
Résumé
The first major COVID-19 outbreak in Germany occurred in Heinsberg in February 2020 with 388 officially reported cases. Unexpectedly, the first outbreak happened in a small town with little to no travelers. We used phylogenetic analyses to investigate the origin and spread of the virus in this outbreak. We sequenced 90 (23%) SARS-CoV-2 genomes from the 388 reported cases including the samples from the first documented cases. Phylogenetic analyses of these sequences revealed mainly two circulating strains with 74 samples assigned to lineage B.3 and 6 samples assigned to lineage B.1. Lineage B.3 was introduced first and probably caused the initial spread. Using phylogenetic analysis tools, we were able to identify closely related strains in France and hypothesized the possible introduction from France.
Identifiants
pubmed: 35574268
doi: 10.1016/j.csbj.2022.05.011
pii: S2001-0370(22)00169-6
pmc: PMC9088089
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2292-2296Informations de copyright
© 2022 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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