Metformin Alleviates Airway Hyperresponsiveness in a Mouse Model of Diet-Induced Obesity.
asthma
insulin resistance
metformin
mouse model
obesity
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
02
2022
accepted:
14
03
2022
entrez:
16
5
2022
pubmed:
17
5
2022
medline:
17
5
2022
Statut:
epublish
Résumé
Obese asthma is a unique phenotype of asthma characterized by non-allergic airway hyperresponsiveness (AHR) and inflammation which responds poorly to standard asthma therapy. Metformin is an oral hypoglycemic drug with insulin-sensitizing and anti-inflammatory properties. The objective of the current study was to test the effect of metformin on AHR in a mouse model of diet-induced obesity (DIO). We fed 12-week-old C57BL/6J DIO mice with a high fat diet for 8 weeks and treated them with either placebo (control,
Identifiants
pubmed: 35574481
doi: 10.3389/fphys.2022.883275
pii: 883275
pmc: PMC9098833
doi:
Types de publication
Journal Article
Langues
eng
Pagination
883275Informations de copyright
Copyright © 2022 Gu, Loube, Lee, Bevans-Fonti, Wu, Barmine, Jun, McCormack, Hansel, Mitzner and Polotsky.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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