Loss of β-Ketoacyl Acyl Carrier Protein Synthase III Activity Restores Multidrug-Resistant Escherichia coli Sensitivity to Previously Ineffective Antibiotics.
antibiotic potentiation
fatty acid biosynthesis
multidrug resistance
outer membrane permeability
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
29 06 2022
29 06 2022
Historique:
pubmed:
17
5
2022
medline:
2
7
2022
entrez:
16
5
2022
Statut:
ppublish
Résumé
Antibiotic resistance is one of the most prominent threats to modern medicine. In the latest World Health Organization list of bacterial pathogens that urgently require new antibiotics, 9 out of 12 are Gram-negative, with four being of "critical priority." One crucial barrier restricting antibiotic efficacy against Gram-negative bacteria is their unique cell envelope. While fatty acids are a shared constituent of all structural membrane lipids, their biosynthesis pathway in bacteria is distinct from eukaryotes, making it an attractive target for new antibiotic development that remains less explored. Here, we interrogated the redundant components of the bacterial type II
Identifiants
pubmed: 35574679
doi: 10.1128/msphere.00117-22
pmc: PMC9241538
doi:
Substances chimiques
Anti-Bacterial Agents
0
Fatty Acids
0
Membrane Lipids
0
Transferases (Other Substituted Phosphate Groups)
EC 2.7.8.-
holo-(acyl-carrier-protein) synthase
EC 2.7.8.7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0011722Références
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