Chemical Approaches to Synthetic Drug Delivery Systems for Systemic Applications.
Drug Delivery Systems
PEGylation
Polymer-Drug Conjugates
Polymer-Protein Conjugates
Self-Assembled Systems
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
05 12 2022
05 12 2022
Historique:
received:
16
03
2022
pubmed:
17
5
2022
medline:
1
12
2022
entrez:
16
5
2022
Statut:
ppublish
Résumé
Poor water solubility and low bioavailability of active pharmaceutical ingredients (APIs) are major causes of friction in the pharmaceutical industry and represent a formidable hurdle for pharmaceutical drug development. Drug delivery remains the major challenge for the application of new small-molecule drugs as well as biopharmaceuticals. The three challenges for synthetic delivery systems are: (i) controlling drug distribution and clearance in the blood; (ii) solubilizing poorly water-soluble agents, and (iii) selectively targeting specific tissues. Although several polymer-based systems have addressed the first two demands and have been translated into clinical practice, no targeted synthetic drug delivery system has reached the market. This Review is designed to provide a background on the challenges and requirements for the design and translation of new polymer-based delivery systems. This report will focus on chemical approaches to drug delivery for systemic applications.
Identifiants
pubmed: 35575255
doi: 10.1002/anie.202203942
pmc: PMC10091760
doi:
Substances chimiques
Pharmaceutical Preparations
0
Polymers
0
Water
059QF0KO0R
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202203942Informations de copyright
© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
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