Cryo-electron Microscopy of Adeno-associated Virus.
Journal
Chemical reviews
ISSN: 1520-6890
Titre abrégé: Chem Rev
Pays: United States
ID NLM: 2985134R
Informations de publication
Date de publication:
14 09 2022
14 09 2022
Historique:
pubmed:
17
5
2022
medline:
16
9
2022
entrez:
16
5
2022
Statut:
ppublish
Résumé
Adeno-associated virus (AAV) has a single-stranded DNA genome encapsidated in a small icosahedrally symmetric protein shell with 60 subunits. AAV is the leading delivery vector in emerging gene therapy treatments for inherited disorders, so its structure and molecular interactions with human hosts are of intense interest. A wide array of electron microscopic approaches have been used to visualize the virus and its complexes, depending on the scientific question, technology available, and amenability of the sample. Approaches range from subvolume tomographic analyses of complexes with large and flexible host proteins to detailed analysis of atomic interactions within the virus and with small ligands at resolutions as high as 1.6 Å. Analyses have led to the reclassification of glycan receptors as attachment factors, to structures with a new-found receptor protein, to identification of the epitopes of antibodies, and a new understanding of possible neutralization mechanisms. AAV is now well-enough characterized that it has also become a model system for EM methods development. Heralding a new era, cryo-EM is now also being deployed as an analytic tool in the process development and production quality control of high value pharmaceutical biologics, namely AAV vectors.
Identifiants
pubmed: 35575684
doi: 10.1021/acs.chemrev.1c00936
pmc: PMC9479082
doi:
Substances chimiques
Epitopes
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
14018-14054Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM122564
Pays : United States
Références
Nucleic Acids Res. 2020 Dec 16;48(22):12983-12999
pubmed: 33270897
Adv Protein Chem. 2003;64:125-96
pubmed: 13677047
Mol Ther. 2011 Aug;19(8):1440-8
pubmed: 21610699
J Virol. 1998 Mar;72(3):2224-32
pubmed: 9499080
Mol Ther. 2017 May 3;25(5):1163-1167
pubmed: 28411016
J Struct Biol. 2015 Nov;192(2):204-8
pubmed: 26278979
J Chem Inf Model. 2020 May 26;60(5):2552-2560
pubmed: 32043355
Mol Ther Methods Clin Dev. 2017 Mar 08;5:1-12
pubmed: 28480299
Nat Genet. 2015 Oct;47(10):1187-93
pubmed: 26301494
Trends Microbiol. 2022 May;30(5):432-451
pubmed: 34711462
Methods Mol Biol. 2011;807:301-15
pubmed: 22034036
J Virol. 1993 Mar;67(3):1148-58
pubmed: 7679742
Muscle Nerve. 2017 Nov;56(5):943-953
pubmed: 28370029
Nat Genet. 2015 Oct;47(10):1104-5
pubmed: 26417859
J Struct Biol. 2013 Nov;184(2):129-35
pubmed: 24036405
Science. 1965 Aug 13;149(3685):754-6
pubmed: 14325163
Mol Biol Evol. 2018 Jun 1;35(6):1547-1549
pubmed: 29722887
Nat Commun. 2021 Jun 7;12(1):3399
pubmed: 34099703
J Virol. 2008 Jun;82(12):5887-911
pubmed: 18400866
Hum Mol Genet. 2011 Apr 15;20(R1):R2-6
pubmed: 21531790
J Gen Virol. 2012 Sep;93(Pt 9):1887-1898
pubmed: 22694902
J Virol. 1995 Nov;69(11):7334-8
pubmed: 7474165
J Virol. 2020 Sep 15;94(19):
pubmed: 32669336
J Mol Biol. 2011 Feb 18;406(2):228-56
pubmed: 21035459
Nat Commun. 2019 Aug 21;10(1):3760
pubmed: 31434885
Ultramicroscopy. 2006 Mar;106(4-5):376-82
pubmed: 16384646
Nat Biotechnol. 2009 Jan;27(1):59-65
pubmed: 19098898
Anal Chem. 2016 Jul 5;88(13):6718-25
pubmed: 27310298
J Virol. 1997 Feb;71(2):1341-52
pubmed: 8995658
Curr Gene Ther. 2010 Oct;10(5):319-340
pubmed: 20712583
Elife. 2019 May 22;8:
pubmed: 31115336
Nature. 2020 Nov;587(7832):152-156
pubmed: 33087931
J Bacteriol. 1965 Jul;90(1):271-4
pubmed: 16562029
J Virol. 2021 Sep 9;95(19):e0084321
pubmed: 34260280
Mol Ther. 2008 Oct;16(10):1703-9
pubmed: 18728640
Elife. 2015 May 29;4:e06980
pubmed: 26023829
Nat Commun. 2015 Nov 04;6:8843
pubmed: 26534841
J Virol. 2012 Sep;86(17):9163-74
pubmed: 22696661
Hum Gene Ther. 2006 Apr;17(4):440-7
pubmed: 16610931
J Virol. 2012 Aug;86(15):7739-51
pubmed: 22593150
J Infect Dis. 2009 Feb 1;199(3):381-90
pubmed: 19133809
J Virol. 1999 May;73(5):3994-4003
pubmed: 10196295
J Virol. 2014 Mar;88(5):2991-3003
pubmed: 24371066
Proc Natl Acad Sci U S A. 1966 Jun;55(6):1467-74
pubmed: 5227666
Mol Ther. 2016 Apr;24(4):660-1
pubmed: 27081717
Nature. 2016 Feb 4;530(7588):108-12
pubmed: 26814968
Gene. 1983 Jul;23(1):65-73
pubmed: 6352411
J Virol. 1983 May;46(2):523-9
pubmed: 6302317
Mol Ther. 2008 Mar;16(3):541-7
pubmed: 18180780
Mol Ther. 2009 Jul;17(7):1187-96
pubmed: 19367261
J Virol. 2011 May;85(10):4822-7
pubmed: 21367911
Mol Ther. 2021 Feb 3;29(2):464-488
pubmed: 33309881
J Virol. 2018 Dec 10;93(1):
pubmed: 30333169
Virology. 2018 May;518:369-376
pubmed: 29604478
Nat Biotechnol. 2003 Sep;21(9):1040-6
pubmed: 12897791
Methods Enzymol. 2016;579:125-57
pubmed: 27572726
Nat Commun. 2020 Sep 7;11(1):4445
pubmed: 32895380
FEBS Lett. 2017 Sep;591(17):2520-2533
pubmed: 28726246
Structure. 1998 Nov 15;6(11):1369-81
pubmed: 9817841
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
J Virol Methods. 2004 Dec 1;122(1):17-27
pubmed: 15488616
Gene Ther. 2008 Feb;15(4):239-46
pubmed: 18046427
Curr Opin Struct Biol. 2018 Oct;52:25-31
pubmed: 30096461
J Virol. 1998 Nov;72(11):8568-77
pubmed: 9765395
Viruses. 2020 Oct 20;12(10):
pubmed: 33092282
J Biol Chem. 2001 Jun 8;276(23):20610-6
pubmed: 11262413
Mol Ther Methods Clin Dev. 2019 Dec 25;17:198-208
pubmed: 31970198
Hum Gene Ther. 2010 Jun;21(6):704-12
pubmed: 20095819
J Virol. 2001 Jul;75(14):6615-24
pubmed: 11413329
Nat Rev Drug Discov. 2019 May;18(5):358-378
pubmed: 30710128
J Virol. 2006 Jul;80(14):7265-9
pubmed: 16809332
Front Immunol. 2021 Apr 01;12:658038
pubmed: 33868303
Gene Ther. 2008 Jun;15(11):808-16
pubmed: 18385765
J Virol. 2012 Jul;86(13):7326-33
pubmed: 22514350
Mol Ther. 2015 Nov;23(11):1673-1675
pubmed: 26606658
Science. 2016 Jul 29;353(6298):506-8
pubmed: 27417497
Nat Med. 2003 Oct;9(10):1306-12
pubmed: 14502277
J Virol. 2006 Jan;80(2):810-20
pubmed: 16378983
Elife. 2016 Sep 26;5:
pubmed: 27669148
Science. 2021 Aug 20;373(6557):871-876
pubmed: 34282049
Nat Med. 1999 Jan;5(1):78-82
pubmed: 9883843
J Struct Biol. 2007 May;158(2):182-7
pubmed: 17116403
Curr Gene Ther. 2003 Aug;3(4):281-304
pubmed: 12871018
AIDS Res Hum Retroviruses. 2008 Jun;24(6):873-80
pubmed: 18544020
Viruses. 2019 Apr 20;11(4):
pubmed: 31010002
Nat Med. 2010 Jun;16(6):662-4
pubmed: 20473307
Virology. 1979 Feb;93(1):237-45
pubmed: 219599
Mol Ther. 2021 Apr 7;29(4):1353-1354
pubmed: 33743193
Nat Med. 1999 May;5(5):467-8
pubmed: 10229209
J Virol. 2008 Aug;82(16):7875-85
pubmed: 18524821
Drugs. 2019 Jul;79(11):1255-1262
pubmed: 31270752
J Virol. 2009 Dec;83(24):12738-50
pubmed: 19812149
Nat Med. 1997 Nov;3(11):1295-7
pubmed: 9359708
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11854-9
pubmed: 12192090
Mol Med Today. 2000 Nov;6(11):433-40
pubmed: 11074369
Mol Ther. 2014 Jul;22(7):1299-1309
pubmed: 24781136
Virology. 2009 Mar 15;385(2):434-43
pubmed: 19144372
J Gene Med. 1999 May-Jun;1(3):166-75
pubmed: 10738565
Hum Gene Ther. 2008 Jul;19(7):663-9
pubmed: 18549307
Virology. 1992 Dec;191(2):600-6
pubmed: 1333115
J Virol. 2012 Oct;86(19):10408-17
pubmed: 22787229
J Virol. 2021 Sep 27;95(20):e0116421
pubmed: 34346767
J Virol. 2022 Jul 13;96(13):e0010622
pubmed: 35674430
N Engl J Med. 2017 Nov 2;377(18):1713-1722
pubmed: 29091557
Sci Transl Med. 2012 Feb 8;4(120):120ra15
pubmed: 22323828
J Virol. 1998 Feb;72(2):1438-45
pubmed: 9445046
Nucleic Acids Res. 2000 Jan 1;28(1):235-42
pubmed: 10592235
J Virol. 1995 Oct;69(10):5951-8
pubmed: 7545239
J Virol. 2006 Sep;80(18):9093-103
pubmed: 16940521
J Med Virol. 1999 Nov;59(3):406-11
pubmed: 10502275
Structure. 2008 Feb;16(2):295-307
pubmed: 18275820
J Virol. 2015 Feb;89(3):1660-72
pubmed: 25410855
Nat Methods. 2018 Dec;15(12):1083-1089
pubmed: 30504871
Biochim Biophys Acta Gen Subj. 2018 Feb;1862(2):324-334
pubmed: 28756276
Blood. 2013 Jul 4;122(1):23-36
pubmed: 23596044
Science. 1991 Mar 22;251(5000):1456-64
pubmed: 2006420
Hum Gene Ther Methods. 2015 Dec;26(6):228-42
pubmed: 26414997
Mol Ther. 2021 Feb 3;29(2):597-610
pubmed: 33309883
J Virol. 1999 Sep;73(9):7912-5
pubmed: 10438891
Mol Ther. 2011 Jun;19(6):1070-8
pubmed: 21364538
AIDS Res Hum Retroviruses. 2010 Aug;26(8):933-42
pubmed: 20666584
J Virol. 2006 Jan;80(2):821-34
pubmed: 16378984
J Virol. 2005 Jan;79(1):609-14
pubmed: 15596854
Hum Gene Ther. 1998 Mar 1;9(4):477-85
pubmed: 9525309
Viruses. 2019 Jan 04;11(1):
pubmed: 30621179
Mol Ther. 2021 Feb 3;29(2):680-690
pubmed: 33554867
J Virol. 2006 Oct;80(19):9831-6
pubmed: 16973587
Acta Crystallogr D Struct Biol. 2018 Jun 1;74(Pt 6):531-544
pubmed: 29872004
Virology. 1999 Feb 1;254(1):169-81
pubmed: 9927584
Mol Ther Methods Clin Dev. 2020 Mar 17;17:601-611
pubmed: 32280726
Nature. 2020 Nov;587(7832):157-161
pubmed: 33087927
Curr Opin Struct Biol. 2019 Oct;58:105-114
pubmed: 31394387
Virology. 2010 Jul 20;403(1):26-36
pubmed: 20444480
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10405-10
pubmed: 12136130
EMBO J. 1991 Dec;10(12):3941-50
pubmed: 1657596
Elife. 2019 Mar 04;8:
pubmed: 30829573
Mol Ther. 2018 Jan 3;26(1):289-303
pubmed: 29055620
J Gen Virol. 2002 May;83(Pt 5):973-978
pubmed: 11961250
Int J Mol Med. 2007 Feb;19(2):325-33
pubmed: 17203208
J Virol. 2005 May;79(9):5296-303
pubmed: 15827144
Bio Protoc. 2020 Feb 05;10(3):e3513
pubmed: 33654738
J Struct Biol. 1999 Apr-May;125(2-3):185-95
pubmed: 10222274
Annu Rev Biophys. 2016 Jul 5;45:253-78
pubmed: 27145875
Pharm Res. 2008 Mar;25(3):489-99
pubmed: 17763830
Cell. 1990 May 4;61(3):447-57
pubmed: 2159383
Biomedicines. 2014 Mar 03;2(1):80-97
pubmed: 28548061
J Virol. 2013 Oct;87(20):11187-99
pubmed: 23926356
Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17148-53
pubmed: 16284249
Mol Ther Methods Clin Dev. 2020 May 22;18:98-118
pubmed: 32995354
J Virol. 2017 Aug 24;91(18):
pubmed: 28679762
Mol Ther. 2005 Jun;11(6):856-65
pubmed: 15922956
Gene Ther. 2019 Jun;26(6):240-249
pubmed: 30962536
Annu Rev Immunol. 2012;30:429-57
pubmed: 22224772
J Virol. 2005 Apr;79(8):5047-58
pubmed: 15795290
Mol Ther. 2012 Feb;20(2):443-55
pubmed: 22068425
Cold Spring Harb Symp Quant Biol. 1962;27:1-24
pubmed: 14019094
Nat Biotechnol. 2016 Feb;34(2):204-9
pubmed: 26829320
Expert Opin Biol Ther. 2015 Jun;15(6):845-55
pubmed: 25985812
Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4812-E4821
pubmed: 28559317
J Virol. 2016 Sep 12;90(19):8542-51
pubmed: 27440903
Pediatr Pulmonol. 2019 Feb;54(2):179-185
pubmed: 30548438
J Struct Biol. 2022 Mar;214(1):107826
pubmed: 34915128
Hum Gene Ther. 2011 Aug;22(8):1021-30
pubmed: 21381980
Structure. 2005 Mar;13(3):389-400
pubmed: 15766540
Int J Mol Med. 2000 Jul;6(1):17-27
pubmed: 10851261
Hum Gene Ther. 2015 Oct;26(10):688-97
pubmed: 26134901
J Biol Chem. 2011 Apr 15;286(15):13532-40
pubmed: 21330365
J Virol. 2010 Dec;84(24):12945-57
pubmed: 20861247
Curr Opin Microbiol. 2018 Jun;43:1-8
pubmed: 29100109
Nat Med. 1999 Jan;5(1):71-7
pubmed: 9883842
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt 12):1271-4
pubmed: 17142915
Sci Transl Med. 2013 Jun 12;5(189):189ra76
pubmed: 23761039
J Virol. 1997 Aug;71(8):5932-41
pubmed: 9223483
Science. 2019 Nov 8;366(6466):714-723
pubmed: 31699932
J Virol. 2013 Aug;87(16):9111-24
pubmed: 23760240
J Virol. 2000 Sep;74(18):8635-47
pubmed: 10954565
Mol Ther. 2018 Feb 7;26(2):510-523
pubmed: 29175157
Cell. 2015 Apr 23;161(3):450-457
pubmed: 25910205
Mol Ther. 2003 Jul;8(1):151-7
pubmed: 12842438
J Virol. 2001 Aug;75(15):6884-93
pubmed: 11435568
J Struct Biol. 2009 Mar;165(3):146-56
pubmed: 19121398
Acta Crystallogr F Struct Biol Commun. 2020 Feb 1;76(Pt 2):58-64
pubmed: 32039886
Nat Commun. 2018 Sep 7;9(1):3628
pubmed: 30194371
Curr Top Microbiol Immunol. 1996;218:1-23
pubmed: 8794242
Hum Gene Ther. 2019 May;30(5):571-589
pubmed: 30358434
Virology. 2012 Feb 5;423(1):6-13
pubmed: 22169623
J Virol. 2013 May;87(9):4974-84
pubmed: 23427155
J Virol. 2003 Feb;77(4):2768-74
pubmed: 12552020
Nat Microbiol. 2019 Apr;4(4):675-682
pubmed: 30742069
J Virol. 2004 Jun;78(12):6381-8
pubmed: 15163731
Science. 1986 Sep 19;233(4770):1286-93
pubmed: 3018924
J Struct Biol. 2018 Sep;203(3):236-241
pubmed: 29775653
Microbes Infect. 2012 Sep;14(11):1000-7
pubmed: 22626929
Mol Ther. 2009 Jul;17(7):1215-24
pubmed: 19367258
Mol Ther. 2020 Feb 5;28(2):367-381
pubmed: 31784416
Nucleic Acids Res. 2011 Jan;39(Database issue):D456-64
pubmed: 20935055
J Cell Biol. 2013 Aug 5;202(3):407-19
pubmed: 23918936
Nature. 2020 Jan;577(7792):706-710
pubmed: 31942072
J Struct Biol. 2020 Aug 1;211(2):107547
pubmed: 32522552
Mol Med Rep. 2019 Feb;19(2):1016-1023
pubmed: 30569131
EMBO J. 1999 Jan 15;18(2):297-305
pubmed: 9889186
J Virol. 2020 Oct 14;94(21):
pubmed: 32817219
J Virol. 2007 Nov;81(22):12260-71
pubmed: 17728238
Virology. 2011 Nov 10;420(1):10-9
pubmed: 21917284
J Gen Virol. 2012 Feb;93(Pt 2):347-355
pubmed: 22071509
Mol Ther. 2018 Mar 7;26(3):664-668
pubmed: 29428298
J Virol. 2000 Mar;74(5):2420-5
pubmed: 10666273
Annu Rev Biochem. 1990;59:439-73
pubmed: 2197980
Curr Opin Virol. 2014 Aug;7:108-18
pubmed: 25047752
Nat Commun. 2014;5:3075
pubmed: 24435020
Front Immunol. 2014 Jan 30;5:9
pubmed: 24523720
Hum Gene Ther. 2011 Nov;22(11):1389-401
pubmed: 21476868
J Virol. 2008 Sep;82(17):8911-6
pubmed: 18524816
J Virol. 2003 Oct;77(20):11072-81
pubmed: 14512555
Nat Med. 1999 Sep;5(9):1052-6
pubmed: 10470084
Viruses. 2020 Nov 18;12(11):
pubmed: 33218165
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11288-94
pubmed: 8876128
Stem Cells Dev. 2004 Feb;13(1):133-45
pubmed: 15068701
Mol Ther. 2008 Oct;16(10):1648-56
pubmed: 18682697
Virol J. 2013 Mar 06;10:74
pubmed: 23497173
Hum Gene Ther. 2020 Jul;31(13-14):695-696
pubmed: 32605399
J Virol. 2006 Jan;80(1):161-71
pubmed: 16352540
J Virol. 1988 Aug;62(8):2745-54
pubmed: 2839699
Cell Host Microbe. 2021 Sep 8;29(9):1437-1453.e8
pubmed: 34428428
Elife. 2018 Nov 09;7:
pubmed: 30412051
Science. 2007 Jul 27;317(5837):477
pubmed: 17656716
J Virol. 2016 May 12;90(11):5219-5230
pubmed: 26962225
Nat Methods. 2021 Feb;18(2):156-164
pubmed: 33542514
Curr Opin Virol. 2014 Oct;8:90-7
pubmed: 25128609
Acta Crystallogr D Struct Biol. 2018 Sep 1;74(Pt 9):814-840
pubmed: 30198894
J Virol. 2004 Apr;78(7):3361-71
pubmed: 15016858
J Virol. 2012 Jun;86(12):6947-58
pubmed: 22496238
J Virol. 2020 Feb 28;94(6):
pubmed: 31826994
Virology. 2012 Sep 15-30;431(1-2):40-9
pubmed: 22682774
Curr Gene Ther. 2005 Jun;5(3):285-97
pubmed: 15975006
N Engl J Med. 2011 Dec 22;365(25):2357-65
pubmed: 22149959
Cell. 1983 May;33(1):135-43
pubmed: 6088052
J Mol Biol. 2020 Apr 17;432(9):2846-2860
pubmed: 32061933
Gut. 2020 Apr;69(4):737-747
pubmed: 31375600
J Struct Biol. 2015 Nov;192(2):196-203
pubmed: 26391007
J Mol Biol. 2011 Jun 10;409(3):427-38
pubmed: 21463638
J Virol. 2015 Feb;89(3):1794-808
pubmed: 25410874
Mol Ther. 2011 Nov;19(11):2084-91
pubmed: 21629225
J Virol. 1998 Dec;72(12):9795-805
pubmed: 9811715
Adv Mater. 2021 Sep;33(37):e2103221
pubmed: 34302401
Gene Ther. 2000 Jun;7(11):924-9
pubmed: 10849551
J Virol. 2000 Oct;74(19):9281-93
pubmed: 10982375
Virology. 1996 Mar 1;217(1):124-30
pubmed: 8599196
Curr Gene Ther. 2005 Jun;5(3):323-31
pubmed: 15975009
Mol Ther. 2022 Jan 5;30(1):283-294
pubmed: 34298129
Contrib Microbiol. 2000;4:59-67
pubmed: 10941570
Virology. 1993 Jun;194(2):491-508
pubmed: 8503170
J Virol. 2006 Sep;80(18):8961-9
pubmed: 16940508
Protein Eng. 2000 Dec;13(12):819-24
pubmed: 11239080
Gene Ther. 2015 Feb;22(2):196-201
pubmed: 25410741
J Virol. 2008 Aug;82(15):7306-12
pubmed: 18508892
J Virol. 2006 Nov;80(22):11040-54
pubmed: 16956943
J Struct Biol. 2020 Feb 1;209(2):107433
pubmed: 31859208
Mol Ther. 2011 Nov;19(11):1971-80
pubmed: 21811247
J Struct Biol. 2015 Oct;192(1):21-36
pubmed: 26334681
Mol Ther. 2021 Feb 3;29(2):418-419
pubmed: 33472035
Blood. 2005 Feb 15;105(4):1424-30
pubmed: 15507527
J Virol. 2000 Feb;74(3):1524-32
pubmed: 10627564
Viruses. 2021 Jan 13;13(1):
pubmed: 33450892
Viral Immunol. 2021 Jan-Feb;34(1):3-17
pubmed: 32315582
Hum Gene Ther. 2015 Dec;26(12):779-81
pubmed: 26690810
Mol Ther. 2019 Mar 6;27(3):611-622
pubmed: 30772143
J Virol. 2018 Mar 14;92(7):
pubmed: 29343568
Curr Opin Struct Biol. 2000 Apr;10(2):146-52
pubmed: 10753815
J Virol. 2005 Feb;79(4):2528-40
pubmed: 15681453
Front Immunol. 2020 Apr 17;11:670
pubmed: 32362898
J Virol. 2002 Jan;76(2):791-801
pubmed: 11752169
J Mol Biol. 1996 Dec 6;264(3):497-520
pubmed: 8969301
J Virol. 2018 Sep 26;92(20):
pubmed: 30089698
Nat Commun. 2020 Jun 30;11(1):3279
pubmed: 32606306
J Gen Virol. 2000 Aug;81(Pt 8):2077-2084
pubmed: 10900047
Structure. 2012 Aug 8;20(8):1310-20
pubmed: 22727812
Arch Virol. 2020 Sep;165(9):2133-2146
pubmed: 32533329
J Struct Biol. 2017 Feb;197(2):94-101
pubmed: 27235783
J Struct Biol. 2013 Apr;182(1):10-21
pubmed: 23376441
Hum Gene Ther. 2019 Dec;30(12):1449-1460
pubmed: 31530236
Gene Ther. 2008 Jan;15(1):54-60
pubmed: 17960164
J Virol. 2006 Nov;80(22):11393-7
pubmed: 16943302
Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):959-70
pubmed: 12777756
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Nov 1;64(Pt 11):1074-8
pubmed: 18997346
Biopolymers. 2012 Sep;97(9):651-4
pubmed: 22696402
Dev Cell. 2001 Aug;1(2):291-302
pubmed: 11702787
J Virol. 2000 Feb;74(4):1761-6
pubmed: 10644347
Biochemistry. 2013 Sep 10;52(36):6275-85
pubmed: 23952613
Mol Ther. 2017 Dec 6;25(12):2661-2675
pubmed: 28890324
Mol Ther Methods Clin Dev. 2018 Feb 13;9:119-129
pubmed: 29766022
Mol Ther. 2019 May 8;27(5):912-921
pubmed: 30819613
Acta Crystallogr D Biol Crystallogr. 2015 Jan 1;71(Pt 1):136-53
pubmed: 25615868
Nat Med. 2006 Mar;12(3):342-7
pubmed: 16474400
Acta Crystallogr D Biol Crystallogr. 2000 Oct;56(Pt 10):1341-9
pubmed: 10998631
BMC Struct Biol. 2018 Dec 19;18(1):19
pubmed: 30563492
J Struct Biol. 2007 Jan;157(1):281-7
pubmed: 16963278
J Immunol. 2013 Aug 1;191(3):1428-35
pubmed: 23797669
Nucleic Acids Res. 2004 Mar 19;32(5):1792-7
pubmed: 15034147
EMBO J. 2001 Jun 15;20(12):3282-91
pubmed: 11406604
Cell. 2020 Apr 2;181(1):136-150
pubmed: 32243786
Structure. 1998 Nov 15;6(11):1355-67
pubmed: 9817847
J Virol. 2006 Dec;80(23):11556-70
pubmed: 16971437
Cell Mol Neurobiol. 2011 Jan;31(1):27-35
pubmed: 20697954
Curr Gene Ther. 2005 Jun;5(3):265-71
pubmed: 15975004
J Virol. 2021 Sep 9;95(19):e0058721
pubmed: 34232726
EMBO Rep. 2001 Nov;2(11):997-1002
pubmed: 11713191
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt 2):177-83
pubmed: 19194015
J Gene Med. 2006 Feb;8(2):155-62
pubmed: 16285001
Protein Sci. 1993 Mar;2(3):459-69
pubmed: 8384042