Safety and Efficacy of Postoperative Nonsteroidal Anti-inflammatory Drugs in Sports Medicine.
Journal
The Journal of the American Academy of Orthopaedic Surgeons
ISSN: 1940-5480
Titre abrégé: J Am Acad Orthop Surg
Pays: United States
ID NLM: 9417468
Informations de publication
Date de publication:
15 Jun 2022
15 Jun 2022
Historique:
received:
22
12
2021
accepted:
25
02
2022
pubmed:
17
5
2022
medline:
7
6
2022
entrez:
16
5
2022
Statut:
ppublish
Résumé
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for multimodal pain control after surgery. These medications work by selective or nonselective inhibition of cyclooxygenase, which has downstream effects on thromboxanes, prostaglandins, and prostacyclins. Clinical studies have shown beneficial effects for alleviating pain and reducing opioid consumption after surgery. Within hip arthroscopy, there is evidence that postoperative NSAIDs can also reduce the risk of symptomatic heterotopic bone formation. However, preclinical and animal studies have raised concern over the effect of NSAIDs on bone and soft-tissue healing. In addition, selective and nonselective cyclooxygenase 2 inhibitors may have different safety profiles regarding postoperative soft-tissue healing. The purpose of this review was to outline the mechanisms of action, efficacy, and effect on soft-tissue healing of postoperative NSAIDs and to provide evidence-based recommendations for appropriate use.
Identifiants
pubmed: 35576538
doi: 10.5435/JAAOS-D-21-01228
pii: 00124635-202206150-00001
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Cyclooxygenase 2 Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
535-542Informations de copyright
Copyright © 2022 by the American Academy of Orthopaedic Surgeons.
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