Successful neutrophil engraftment supported by granulocyte transfusion in adult allogeneic transplant patients with peri-transplant active infection.
Allogeneic hematopoietic stem cell transplantation
Granulocyte transfusion
Infection
Journal
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
ISSN: 1473-0502
Titre abrégé: Transfus Apher Sci
Pays: England
ID NLM: 101095653
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
10
12
2021
revised:
23
03
2022
accepted:
03
05
2022
pubmed:
17
5
2022
medline:
6
12
2022
entrez:
16
5
2022
Statut:
ppublish
Résumé
Active infection at the time of allogeneic hematopoietic stem cell transplantation (HSCT) is a risk for non-relapse mortality (NRM) after HSCT. Granulocyte transfusion (GTX) has been used to prevent or treat life-threatening infections in patients with severe neutropenia. However, data are limited on the clinical benefits of GTX during HSCT. We retrospectively analyzed the transplant outcomes of HSCT patients who had undergone GTX between 2012 and 2020. Altogether, 20 patients with documented infection had received 55 GTXs during HSCT. No adverse events were observed during the GTX infusion. The average number of granulocytes was 0.40 (range, 0.10-1.59) × 10
Identifiants
pubmed: 35577683
pii: S1473-0502(22)00126-4
doi: 10.1016/j.transci.2022.103453
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103453Informations de copyright
Copyright © 2022. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of interest The authors declare that they have no conflict of interest.