A genome-wide association study for melatonin secretion.

Circadian Rhythm Genetic Loci Genome-Wide Association Study Humans Melatonin / genetics Polymorphism, Single Nucleotide

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
16 05 2022
Historique:
received: 05 07 2021
accepted: 04 05 2022
entrez: 16 5 2022
pubmed: 17 5 2022
medline: 20 5 2022
Statut: epublish

Résumé

Melatonin exerts a wide range of effects among various tissues and organs. However, there is currently no study to investigate the genetic determinants of melatonin secretion. Here, we conducted a genome-wide association study (GWAS) for melatonin secretion using morning urine 6-hydroxymelatonin sulfate-to-creatinine ratio (UMCR). We initially enrolled 5000 participants from Taiwan Biobank in this study. After excluding individuals that did not have their urine collected in the morning, those who had history of neurological or psychiatric disorder, and those who failed to pass quality control, association of single nucleotide polymorphisms with log-transformed UMCR adjusted for age, sex and principal components of ancestry were analyzed. A second model additionally adjusted for estimated glomerular filtration rate (eGFR). A total of 2373 participants underwent the genome-wide analysis. Five candidate loci associated with log UMCR (P value ranging from 6.83 × 10

Identifiants

DOI: 10.1038/s41598-022-12084-w PMID: 35577822 PMC: PMC9110427
pubmed: 35577822
doi: 10.1038/s41598-022-12084-w
pii: 10.1038/s41598-022-12084-w
pmc: PMC9110427
doi:

Substances chimiques

Melatonin JL5DK93RCL

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8025

Informations de copyright

© 2022. The Author(s).

Références

J Pineal Res. 2005 Apr;38(3):145-52
pubmed: 15725334
J Biol Chem. 1999 Jan 29;274(5):2866-71
pubmed: 9915822
PLoS One. 2015 Apr 21;10(4):e0120758
pubmed: 25898129
Front Neuroendocrinol. 2001 Jan;22(1):18-32
pubmed: 11141317
PLoS Genet. 2021 Aug 2;17(8):e1009716
pubmed: 34339417
J Pineal Res. 2008 Jan;44(1):16-25
pubmed: 18078444
Nephrol Dial Transplant. 2010 Feb;25(2):513-9
pubmed: 19767630
J Pineal Res. 2008 Jan;44(1):26-40
pubmed: 18078445
Nat Rev Genet. 2010 Jul;11(7):499-511
pubmed: 20517342
Mol Neurodegener. 2006 Sep 19;1:12
pubmed: 16984644
Sleep Med Rev. 2005 Feb;9(1):11-24
pubmed: 15649735
Bioinformatics. 2010 Sep 15;26(18):2336-7
pubmed: 20634204
FASEB J. 2014 Aug;28(8):3579-88
pubmed: 24760755
Epidemiology. 2011 Jul;22(4):457-9; discussion 467-8
pubmed: 21642770
Prog Neurobiol. 2011 Mar;93(3):350-84
pubmed: 21193011
Alzheimers Res Ther. 2021 Feb 23;13(1):52
pubmed: 33622399
Arch Biochem Biophys. 2013 Aug 15;536(2):152-7
pubmed: 23500141
World J Diabetes. 2011 Jun 15;2(6):82-91
pubmed: 21860691
Psychoneuroendocrinology. 2006 Aug;31(7):867-75
pubmed: 16769177
J Biol Rhythms. 2005 Aug;20(4):291-303
pubmed: 16077149
Genes Brain Behav. 2012 Jul;11(5):601-13
pubmed: 22487427
J Circadian Rhythms. 2008 Oct 15;6:9
pubmed: 18922153
Biochem Soc Trans. 2019 Feb 28;47(1):89-100
pubmed: 30559272
Hum Mol Genet. 2016 Dec 15;25(24):5321-5331
pubmed: 27798100
Neuropsychopharmacology. 1999 Dec;21(6):765-72
pubmed: 10633482
Genet Epidemiol. 2008 May;32(4):381-5
pubmed: 18348202
Nat Genet. 2012 Jul 22;44(8):955-9
pubmed: 22820512
J Pineal Res. 2003 Sep;35(2):125-30
pubmed: 12887656
Mol Cell Biol. 1991 Dec;11(12):6041-9
pubmed: 1719379
J Biol Chem. 2003 Jan 3;278(1):573-84
pubmed: 12407114
J Biol Chem. 2014 Apr 4;289(14):9662-74
pubmed: 24519931
Science. 2002 Jul 19;297(5580):353-6
pubmed: 12130773
FEBS Lett. 2004 May 21;566(1-3):17-24
pubmed: 15147861
Eur Urol. 2015 Feb;67(2):191-4
pubmed: 25107635
J Pineal Res. 2011 Aug;51(1):1-16
pubmed: 21752095
J Pineal Res. 1997 Nov;23(4):191-7
pubmed: 9462851
J Pineal Res. 2012 Mar;52(2):139-66
pubmed: 22034907
J Biol Chem. 1995 Nov 10;270(45):26840-8
pubmed: 7592926
J Pineal Res. 1998 May;24(4):230-8
pubmed: 9572533
J Pineal Res. 1998 Jan;24(1):58-61
pubmed: 9468119
Am J Med. 1999 Nov;107(5):432-6
pubmed: 10569297
Bioinformatics. 2011 Aug 1;27(15):2156-8
pubmed: 21653522
Eur J Environ Public Health. 2018;2(2):
pubmed: 31259311
Best Pract Res Clin Endocrinol Metab. 2003 Jun;17(2):273-85
pubmed: 12787552
J Biol Rhythms. 2017 Oct;32(5):433-443
pubmed: 28816086
Mol Cell Endocrinol. 2014 Feb 15;382(2):926-37
pubmed: 24291636
Brain Res. 2011 Jun 29;1398:1-12
pubmed: 21636077
BMC Genomics. 2008 Oct 31;9:516
pubmed: 18976480
Clin Genet. 1983 Dec;24(6):399-402
pubmed: 6652952
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
J Biol Chem. 1961 Nov;236:3072-5
pubmed: 14458327
Nat Rev Genet. 2008 May;9(5):356-69
pubmed: 18398418
J Neurosci. 2011 Jul 27;31(30):10836-46
pubmed: 21795536
Nat Methods. 2013 Jan;10(1):5-6
pubmed: 23269371

Auteurs

Pi-Hua Liu (PH)

Clinical Informatics and Medical Statistics Research Center, College of Medicine, Chang Gung University, Taoyüan, Taiwan.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyüan, Taiwan.

Gwo-Tsann Chuang (GT)

Department of Pediatrics, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, 5F, No.2, Xuzhou Rd., Zhongzheng Dist., Taipei, 100, Taiwan.

Chia-Ni Hsiung (CN)

Data Science Statistical Cooperation Center, Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.

Wei-Shun Yang (WS)

Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, 5F, No.2, Xuzhou Rd., Zhongzheng Dist., Taipei, 100, Taiwan.
Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.

Hsiao-Chia Ku (HC)

Department of Laboratory Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.

Yi-Ching Lin (YC)

Department of Laboratory Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.

Yi-Shun Chen (YS)

Department of Laboratory Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.

Yu-Yao Huang (YY)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyüan, Taiwan.
Department of Medical Nutrition Therapy, Lin-Kou Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Taoyüan, Taiwan.

Chia-Hung Lin (CH)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyüan, Taiwan.
Department of Chinese Medicine, College of Medicine, Chang Gung University, Taoyüan, Taiwan.

Wen-Yi Li (WY)

Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan.

Jou-Wei Lin (JW)

Cardiovascular Center, National Taiwan University Hospital Yun-Lin Branch, Yunlin, Taiwan.

Chih-Neng Hsu (CN)

Cardiovascular Center, National Taiwan University Hospital Yun-Lin Branch, Yunlin, Taiwan.

Juey-Jen Hwang (JJ)

Cardiovascular Center, National Taiwan University Hospital Yun-Lin Branch, Yunlin, Taiwan.
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Karen Chia-Wen Liao (KC)

Biological Sciences Division, University of Chicago, Chicago, IL, 60637, USA.

Meng-Lun Hsieh (ML)

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Hsiao-Lin Lee (HL)

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Chen-Yang Shen (CY)

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
College of Public Health, China Medical University, Taichung, Taiwan.

Yi-Cheng Chang (YC)

Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, 5F, No.2, Xuzhou Rd., Zhongzheng Dist., Taipei, 100, Taiwan. b83401040@gmail.com.
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. b83401040@gmail.com.
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. b83401040@gmail.com.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Rythme circadien › A genome-wide association study for melatonin...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › A genome-wide association study for melatonin...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › A genome-wide association study for melatonin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A genome-wide association study for melatonin...
questionsmedicales.fr › Mélatonine › A genome-wide association study for melatonin...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › A genome-wide association study for melatonin...