A Three-Day Intervention With Granola Containing Cereal Beta-Glucan Improves Glycemic Response and Changes the Gut Microbiota in Healthy Individuals: A Crossover Study.

Intake of soluble fibers including beta-glucan, is known to improve post-prandial glycemic response. The mechanisms have been attributed to the viscous gel forming in the stomach and small intestine, giving a longer absorption time. However, recent evidence suggests a link between intake of beta-glucan and improved glycemic regulation at subsequent meals through the gut microbiota. We investigated the short-term effect of granola with different amounts of cereal beta-glucan on glycemic response and gut microbiota. After a two-week run-in period (baseline), fourteen healthy, normal weight adults completed a dose-response dietary crossover study. Different amounts of cereal beta-glucan (low: 0.8 g, medium: 3.2 g and high: 6.6 g) were provided in granola and eaten with 200 ml low-fat milk as an evening meal for three consecutive days. Blood glucose and insulin were measured fasted and after an oral glucose tolerance test (OGTT) the following day, in addition to peptide YY (PYY) and glucagon-like peptide (GLP-2), fasting short chain fatty acids (SCFA) in blood, breath H [www.clinicaltrials.gov], identifier [NCT03293693].

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Copyright © 2022 Telle-Hansen, Gaundal, Høgvard, Ulven, Holven, Byfuglien, Måge, Knutsen, Ballance, Rieder, Rud and Myhrstad.

Déclaration de conflit d'intérêts

The study was performed in collaboration with the food industry (Mills AS) represented by MGB, and Mills AS partially funded the study. VHT-H has been employed at Mills AS. VHT-H does not own any stocks in the company, and the work performed in this manuscript was done after she left the company. VHT-H collaborates with and/or has received research grants from Mills AS, Mesterbakeren, Det Glutenfrie Verksted and Norwegian Celiac Disease Association, none of which are related to the content of this manuscript. SMU has received research grants from TINE, Mills AS, Nortura and Olympic Seafood, none of which are related to the content of this manuscript. KBH has received research grants and/or personal fees from TINE, Mills AS, Amgen, Sanofi and Olympic Seafood, none of which are related to the content of this manuscript. MGB is employed at Mills AS. MGB does not own any stocks in the company and was not involved in the collection or analysis of the data. MCWM is involved in projects with research grants from Tine, Olympic Seafood, Mesterbakeren and Det Glutenfrie Verksted, none of which are related to the content of this manuscript. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.