[Diagnostics and treatment of secondary malignancies of the parotid gland-An overview].
Diagnostik und Therapie sekundärer Malignome der Ohrspeicheldrüse – eine Übersicht.
Carcinoma, squamous cell
Facial nerve
Neck dissection
Radiotherapy, adjuvant
Spinocellular carcinoma
Journal
HNO
ISSN: 1433-0458
Titre abrégé: HNO
Pays: Germany
ID NLM: 2985099R
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
accepted:
30
03
2022
medline:
4
4
2023
pubmed:
18
5
2022
entrez:
17
5
2022
Statut:
ppublish
Résumé
Secondary malignancies of the parotid gland frequently have a cutaneous origin and the incidence in central Europe is increasing. The aim of this review article was to present the epidemiology, (differential) diagnostics and treatment of secondary malignancies of the parotid gland. A literature search of the current guidelines and evidence was carried out in the web-based databank PubMed. The incidence of secondary malignancies of the parotid gland seems to be increasing in Europe, mainly due to a rising incidence of metastases of cutaneous squamous cell carcinomas. Except for malignant lymphomas, parotidectomy is the treatment of choice in the curative situation. In the absence of clear evidence, in the case of an intact facial nerve lateral or total parotidectomy with ipsilateral neck dissection seems to be indicated, depending on the entity of the secondary malignancy. The differential diagnostics of squamous cell carcinoma (in) of the parotid gland can be complicated. When a squamous cell carcinoma of the parotid gland is diagnosed for the first time, a dermatological full body examination and a detailed medical history should be taken with respect to skin tumors of the head and neck region. In addition to surgical treatment of the parotid gland and neck, adjuvant radiotherapy is usually indicated. HINTERGRUND: Sekundäre Malignome der Ohrspeicheldrüse sind häufig kutanen Ursprungs und weisen eine steigende Inzidenz in Mitteleuropa auf. Ziel dieser Übersichtsarbeit war die Darstellung der Epidemiologie, (Differenzial‑)Diagnostik und Therapie sekundärer Malignome in der Ohrspeicheldrüse. Es wurde eine Literaturrecherche aktueller Leitlinien und Evidenz in der webbasierten Datenbank PubMed durchgeführt. Die Inzidenz sekundärer Malignome in der Ohrspeicheldrüse scheint insbesondere aufgrund einer steigenden Inzidenz von Metastasen kutaner Plattenepithelkarzinome in Europa zuzunehmen. Die Parotidektomie ist – außer beim malignen Lymphom – in der kurativen Situation die Therapie der Wahl. In Abwesenheit klarer Evidenz ist, abhängig von der Entität des sekundären Malignoms, bei intaktem Nervus facialis eine laterale oder komplette Parotidektomie mit ipsilateraler Neck dissection indiziert. Die Differenzialdiagnostik bei sekundären Karzinomen (in) der Glandula parotidea kann kompliziert sein. Bei der Erstdiagnose eines Plattenepithelkarzinoms sollten eine dermatologische Ganzkörperuntersuchung und eine genaue Anamnese in Bezug auf Hauttumoren der Kopf-Hals-Region erfolgen. Neben der chirurgischen Therapie der Ohrspeicheldrüse und des Halses ist in der Regel eine adjuvante Radiotherapie indiziert.
Sections du résumé
BACKGROUND
BACKGROUND
Secondary malignancies of the parotid gland frequently have a cutaneous origin and the incidence in central Europe is increasing.
OBJECTIVE
OBJECTIVE
The aim of this review article was to present the epidemiology, (differential) diagnostics and treatment of secondary malignancies of the parotid gland.
MATERIAL AND METHODS
METHODS
A literature search of the current guidelines and evidence was carried out in the web-based databank PubMed.
RESULTS
RESULTS
The incidence of secondary malignancies of the parotid gland seems to be increasing in Europe, mainly due to a rising incidence of metastases of cutaneous squamous cell carcinomas. Except for malignant lymphomas, parotidectomy is the treatment of choice in the curative situation. In the absence of clear evidence, in the case of an intact facial nerve lateral or total parotidectomy with ipsilateral neck dissection seems to be indicated, depending on the entity of the secondary malignancy.
CONCLUSION
CONCLUSIONS
The differential diagnostics of squamous cell carcinoma (in) of the parotid gland can be complicated. When a squamous cell carcinoma of the parotid gland is diagnosed for the first time, a dermatological full body examination and a detailed medical history should be taken with respect to skin tumors of the head and neck region. In addition to surgical treatment of the parotid gland and neck, adjuvant radiotherapy is usually indicated.
ZUSAMMENFASSUNG
UNASSIGNED
HINTERGRUND: Sekundäre Malignome der Ohrspeicheldrüse sind häufig kutanen Ursprungs und weisen eine steigende Inzidenz in Mitteleuropa auf.
FRAGESTELLUNG
UNASSIGNED
Ziel dieser Übersichtsarbeit war die Darstellung der Epidemiologie, (Differenzial‑)Diagnostik und Therapie sekundärer Malignome in der Ohrspeicheldrüse.
MATERIAL UND METHODE
UNASSIGNED
Es wurde eine Literaturrecherche aktueller Leitlinien und Evidenz in der webbasierten Datenbank PubMed durchgeführt.
ERGEBNISSE
UNASSIGNED
Die Inzidenz sekundärer Malignome in der Ohrspeicheldrüse scheint insbesondere aufgrund einer steigenden Inzidenz von Metastasen kutaner Plattenepithelkarzinome in Europa zuzunehmen. Die Parotidektomie ist – außer beim malignen Lymphom – in der kurativen Situation die Therapie der Wahl. In Abwesenheit klarer Evidenz ist, abhängig von der Entität des sekundären Malignoms, bei intaktem Nervus facialis eine laterale oder komplette Parotidektomie mit ipsilateraler Neck dissection indiziert.
SCHLUSSFOLGERUNGEN
UNASSIGNED
Die Differenzialdiagnostik bei sekundären Karzinomen (in) der Glandula parotidea kann kompliziert sein. Bei der Erstdiagnose eines Plattenepithelkarzinoms sollten eine dermatologische Ganzkörperuntersuchung und eine genaue Anamnese in Bezug auf Hauttumoren der Kopf-Hals-Region erfolgen. Neben der chirurgischen Therapie der Ohrspeicheldrüse und des Halses ist in der Regel eine adjuvante Radiotherapie indiziert.
Autres résumés
Type: Publisher
(ger)
HINTERGRUND: Sekundäre Malignome der Ohrspeicheldrüse sind häufig kutanen Ursprungs und weisen eine steigende Inzidenz in Mitteleuropa auf.
Identifiants
pubmed: 35579673
doi: 10.1007/s00106-022-01178-6
pii: 10.1007/s00106-022-01178-6
doi:
Types de publication
English Abstract
Journal Article
Review
Langues
ger
Sous-ensembles de citation
IM
Pagination
223-231Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
Références
Aiyer HM, Deb S, Rawat G (2019) Metastatic hepatocellular carcinoma to the parotid gland: A diagnostic dilemma with review of the literature. Indian J Pathol Microbiol 62:582–585
doi: 10.4103/IJPM.IJPM_272_19
pubmed: 31611444
Becker Jc ET, Frerich B, Gambichler T, Grabbe S, Höller U, Klumpp B, Loquai C, Krause-Bergmann A, Müller-Richter U, Pföhler C, Schneider-Burrus S, Stang A, Terheyden P, Ugurel S, Veith J, Mauch C (2018) S2k-Leitlinie – Merkelzellkarzinom (MZK, MCC, neuroendokrines Karzinom der Haut), S. 1–28. Update
Bron LP, Traynor SJ, Mcneil EB et al (2003) Primary and metastatic cancer of the parotid: comparison of clinical behavior in 232 cases. Laryngoscope 113:1070–1075
doi: 10.1097/00005537-200306000-00029
pubmed: 12782825
Clark J, Wang S (2016) Metastatic cancer to the parotid. Adv Otorhinolaryngol 78:95–103
pubmed: 27092549
Ebrahimi A, Moncrieff MD, Clark JR et al (2010) Predicting the pattern of regional metastases from cutaneous squamous cell carcinoma of the head and neck based on location of the primary. Head Neck 32:1288–1294
doi: 10.1002/hed.21332
pubmed: 20091686
El-Naggar AK, Chan JK, Grandis JR et al (2017) WHO classification of head and neck tumours. International Agency for Research on Cancer
Fields RC, Busam KJ, Chou JF et al (2011) Recurrence and survival in patients undergoing sentinel lymph node biopsy for merkel cell carcinoma: analysis of 153 patients from a single institution. Ann Surg Oncol 18:2529–2537
doi: 10.1245/s10434-011-1662-y
pubmed: 21431988
pmcid: 4117701
Franzen A, Buchali A, Lieder A (2017) The rising incidence of parotid metastases: our experience from four decades of parotid gland surgery. Acta Otorhinolaryngol Ital 37:264–269
doi: 10.14639/0392-100X-1095
pubmed: 28872155
pmcid: 5584096
Franzen A, Lieder A, Guenzel T et al (2019) The heterogenicity of parotid gland squamous cell carcinoma: a study of 49 patients. In Vivo 33:2001–2006
doi: 10.21873/invivo.11696
pubmed: 31662530
pmcid: 6899102
Franzen AM, Kaup Franzen C, Guenzel T et al (2018) Increased incidence of Warthin tumours of the parotid gland: a 42-year evaluation. Eur Arch Otorhinolaryngol 275:2593–2598
doi: 10.1007/s00405-018-5092-3
pubmed: 30121841
Fujiwara M, Suzuki T, Takiguchi T et al (2016) Evaluation of positron emission tomography imaging to detect lymph node metastases in patients with high-risk cutaneous squamous cell carcinoma. J Dermatol 43:1314–1320
doi: 10.1111/1346-8138.13403
pubmed: 27060693
Gillenwater AM, Hessel AC, Morrison WH et al (2001) Merkel cell carcinoma of the head and neck: effect of surgical excision and radiation on recurrence and survival. Arch Otolaryngol Head Neck Surg 127:149–154
doi: 10.1001/archotol.127.2.149
pubmed: 11177031
Harrington C, Kwan W (2016) Radiotherapy and conservative surgery in the locoregional management of Merkel cell carcinoma: the British columbia cancer agency experience. Ann Surg Oncol 23:573–578
doi: 10.1245/s10434-015-4812-9
pubmed: 26286197
Helissey C, Rouanne M, Arnaud FX et al (2015) Parotid gland metastasis from prostate cancer: is docetaxel still the best treatment option? Anticancer Drugs 26:367–370
doi: 10.1097/CAD.0000000000000188
pubmed: 25486600
Iguchi H, Wada T, Matsushita N et al (2012) Anatomic distribution of hematolymphoid malignancies in the head and neck: 7 years of experience with 122 patients in a single institution. Acta Otolaryngol 132:1224–1231
doi: 10.3109/00016489.2012.694474
pubmed: 23025415
(1996) Major and minor salivary glands. In: Ackerman’s surgical pathology, 8. Aufl. Mosby-Year Book, St. Louis
Lachar WA, Shahab I, Saad AJ (2007) Accuracy and cost-effectiveness of core needle biopsy in the evaluation of suspected lymphoma: a study of 101 cases. Arch Pathol Lab Med 131:1033–1039
doi: 10.5858/2007-131-1033-AACOCN
pubmed: 17616988
Lee CC, Faries MB, Wanek LA et al (2008) Improved survival after lymphadenectomy for nodal metastasis from an unknown primary melanoma. J Clin Oncol 26:535–541
doi: 10.1200/JCO.2007.14.0285
pubmed: 18235114
Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft DK, Awmf) (2020) Diagnostik, Therapie und Nachsorge des Melanoms, Langversion 3.3, AWMF Registernummer: 032/024OL
Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft DK, Awmf): (2020) S3-Leitlinie Aktinische Keratose und Plattenepithelkarzinom der Haut, Langversion 1.1, AWMF Registernummer: 032/022OL
Lowes MA, Bishop GA, Crotty K et al (1997) T helper 1 cytokine mRNA is increased in spontaneously regressing primary melanomas. J Invest Dermatol 108:914–919
doi: 10.1111/1523-1747.ep12292705
pubmed: 9182821
Maahs GS, Oppermann PO, Maahs LG et al (2015) Parotid gland tumors: a retrospective study of 154 patients. Braz J Otorhinolaryngol 81:301–306
doi: 10.1016/j.bjorl.2015.03.007
pubmed: 25934418
pmcid: 9452231
Mackenzie K, Watson M, Jankowska P et al (2016) Investigation and management of the unknown primary with metastatic neck disease: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol 130:S170–S175
doi: 10.1017/S0022215116000591
pubmed: 27841129
pmcid: 4873921
Mayer M, Thoelken R, Jering M et al (2021) Metastases of cutaneous squamous cell carcinoma seem to be the most frequent malignancies in the parotid gland: a hospital-based study from a salivary gland center. Head Neck Pathol 15:843–851
doi: 10.1007/s12105-021-01294-9
pubmed: 33544379
pmcid: 8385094
Meyer MF, Wolber P, Arolt C et al (2021) Survival after parotid gland metastases of cutaneous squamous cell carcinoma of the head and neck. Oral Maxillofac Surg 25:383–388
doi: 10.1007/s10006-020-00934-8
pubmed: 33400041
pmcid: 8352831
Pollaers KDN, Hinton-Bayre A (2019) Management of occult neck disease in metastatic squamous cell carcinoma to the parotid gland. Aust J Otolaryngol. https://doi.org/10.21037/ajo.2019.09.01
Schmults CD, Karia PS, Carter JB et al (2013) Factors predictive of recurrence and death from cutaneous squamous cell carcinoma: a 10-year, single-institution cohort study. JAMA Dermatol 149:541–547
doi: 10.1001/jamadermatol.2013.2139
pubmed: 23677079
Singh N, Al-Rikabi A, Foo M (2015) Should we routinely perform ultrasound scans for cutaneous SCC patients? Br J Oral Maxillofac Surg. https://doi.org/10.1016/j.bjoms.2015.08.252
doi: 10.1016/j.bjoms.2015.08.252
pubmed: 26123656
Sonmez Ergun S, Gayretli O, Buyukpinarbasili N et al (2014) Determining the number of intraparotid lymph nodes: postmortem examination. J Craniomaxillofac Surg 42:657–660
doi: 10.1016/j.jcms.2013.09.011
pubmed: 24176654
Thom JJ, Moore EJ, Price DL et al (2014) The role of total parotidectomy for metastatic cutaneous squamous cell carcinoma and malignant melanoma. JAMA Otolaryngol Head Neck Surg 140:548–554
doi: 10.1001/jamaoto.2014.352
pubmed: 24722863
Weiss MH, Harrison LB, Isaacs Rs RS (1994) Use of decision analysis in planning a management strategy for the stage N0 neck. Arch Otolaryngol Head Neck Surg. https://doi.org/10.1001/archotol.1994.01880310005001
doi: 10.1001/archotol.1994.01880310005001
pubmed: 8018319
Wu ZH, Ge MH, Cao J et al (2017) Parotid metastases from thyroid carcinomas. Int J Clin Exp Pathol 10:10467–10474
pubmed: 31966384
pmcid: 6965794
Yoon DY, Hwang HS, Chang SK et al (2009) CT, MR, US,18F-FDG PET/CT, and their combined use for the assessment of cervical lymph node metastases in squamous cell carcinoma of the head and neck. Eur Radiol 19:634–642
doi: 10.1007/s00330-008-1192-6
pubmed: 18843493