Circulating free testosterone and risk of aggressive prostate cancer: Prospective and Mendelian randomisation analyses in international consortia.

Biomarkers Humans Male Mendelian Randomization Analysis Prostate Prostatic Neoplasms / epidemiology Risk Factors Sex Hormone-Binding Globulin / analysis Testosterone
Mendelian randomisation SHBG aggressive prostate cancer prostate cancer testosterone

Journal

International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124

Informations de publication

Date de publication:
01 10 2022
Historique:
revised: 18 02 2022
received: 23 11 2021
accepted: 28 02 2022
pubmed: 18 5 2022
medline: 13 8 2022
entrez: 17 5 2022
Statut: ppublish

Résumé

Previous studies had limited power to assess the associations of testosterone with aggressive disease as a primary endpoint. Further, the association of genetically predicted testosterone with aggressive disease is not known. We investigated the associations of calculated free and measured total testosterone and sex hormone-binding globulin (SHBG) with aggressive, overall and early-onset prostate cancer. In blood-based analyses, odds ratios (OR) and 95% confidence intervals (CI) for prostate cancer were estimated using conditional logistic regression from prospective analysis of biomarker concentrations in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group (up to 25 studies, 14 944 cases and 36 752 controls, including 1870 aggressive prostate cancers). In Mendelian randomisation (MR) analyses, using instruments identified using UK Biobank (up to 194 453 men) and outcome data from PRACTICAL (up to 79 148 cases and 61 106 controls, including 15 167 aggressive cancers), ORs were estimated using the inverse-variance weighted method. Free testosterone was associated with aggressive disease in MR analyses (OR per 1 SD = 1.23, 95% CI = 1.08-1.40). In blood-based analyses there was no association with aggressive disease overall, but there was heterogeneity by age at blood collection (OR for men aged <60 years 1.14, CI = 1.02-1.28; P

Identifiants

DOI: 10.1002/ijc.34116 PMID: 35579976 PMC: PMC7613289
pubmed: 35579976
doi: 10.1002/ijc.34116
pmc: PMC7613289
mid: EMS143942
doi:

Substances chimiques

Biomarkers 0
Sex Hormone-Binding Globulin 0
Testosterone 3XMK78S47O

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1033-1046

Subventions

Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U01 CA182883
Pays : United States
Organisme : Cancer Research UK
ID : A19170
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : UG1 CA189974
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA167552
Pays : United States
Organisme : Cancer Research UK
ID : A29019
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 CA999999
Pays : United States
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA071789
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA164973
Pays : United States

Informations de copyright

© 2022 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.

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Auteurs

Eleanor L Watts (EL)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
ORCID: 0000-0001-9229-2589

Aurora Perez-Cornago (A)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
ORCID: 0000-0002-5652-356X

Georgina K Fensom (GK)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Karl Smith-Byrne (K)

Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France.

Urwah Noor (U)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Colm D Andrews (CD)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Marc J Gunter (MJ)

Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.

Michael V Holmes (MV)

Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.

Richard M Martin (RM)

Department of Population Health Sciences, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and Weston NHS Foundation Trust and the University of Bristol, Bristol, UK.

Konstantinos K Tsilidis (KK)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
ORCID: 0000-0002-8452-8472

Demetrius Albanes (D)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Aurelio Barricarte (A)

Navarra Public Health Institute, Pamplona, Spain.
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain.

Bas Bueno-de-Mesquita (B)

Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), The Netherlands.

Chu Chen (C)

Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
Department of Otolaryngology: Head and Neck Surgery, School of Medicine, University of Washington, Seattle, Washington, USA.

Barbara A Cohn (BA)

Child Health and Development Studies, Public Health Institute, Berkeley, California, USA.

Niki L Dimou (NL)

Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
ORCID: 0000-0003-1678-9328

Luigi Ferrucci (L)

National Institute on Aging, Baltimore, Maryland, USA.

Leon Flicker (L)

Medical School, University of Western Australia, Perth, Western Australia, Australia.
Western Australian Centre for Health and Ageing, University of Western Australia, Perth, Western Australia, Australia.

Neal D Freedman (ND)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Graham G Giles (GG)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.

Edward L Giovannucci (EL)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Gary E Goodman (GE)

Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Christopher A Haiman (CA)

Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, USA.

Graeme J Hankey (GJ)

Medical School, University of Western Australia, Perth, Western Australia, Australia.

Jiaqi Huang (J)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
ORCID: 0000-0002-7808-9477

Wen-Yi Huang (WY)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
ORCID: 0000-0002-4440-3368

Lauren M Hurwitz (LM)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
ORCID: 0000-0001-8932-5028

Rudolf Kaaks (R)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Paul Knekt (P)

Department of Public Health and Welfare, National Institute for Health and Welfare, Helsinki, Finland.

Tatsuhiko Kubo (T)

Department of Public Health and Health Policy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Hilde Langseth (H)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Department of Research, Cancer Registry of Norway, Oslo, Norway.

Gail Laughlin (G)

Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, California, USA.

Loic Le Marchand (L)

University of Hawaii Cancer Center, Honolulu, Hawaii, USA.

Tapio Luostarinen (T)

Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
ORCID: 0000-0003-3231-8550

Robert J MacInnis (RJ)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.

Hanna O Mäenpää (HO)

Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.

Satu Männistö (S)

Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.

E Jeffrey Metter (EJ)

Department of Neurology, The University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee, USA.

Kazuya Mikami (K)

Departmemt of Urology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan.

Lorelei A Mucci (LA)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Anja W Olsen (AW)

Department of Public Health, Aarhus University, Aarhus, Denmark.
Danish Cancer Society, Research Center, Copenhagen, Denmark.

Kotaro Ozasa (K)

Departmemt of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan.

Domenico Palli (D)

Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy.
ORCID: 0000-0002-5558-2437

Kathryn L Penney (KL)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Elizabeth A Platz (EA)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
ORCID: 0000-0003-3676-8954

Harri Rissanen (H)

Department of Public Health and Welfare, National Institute for Health and Welfare, Helsinki, Finland.

Norie Sawada (N)

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
ORCID: 0000-0002-9936-1476

Jeannette M Schenk (JM)

Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Pär Stattin (P)

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Akiko Tamakoshi (A)

Hokkaido University Faculty of Medicine, Sapporo, Japan.

Elin Thysell (E)

Department of Medical Biosciences, Umeå University, Umeå, Sweden.

Chiaojung Jillian Tsai (CJ)

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Shoichiro Tsugane (S)

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.

Lars Vatten (L)

Department of Public Health and Nursing, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Elisabete Weiderpass (E)

Director Office, International Agency for Research on Cancer, World Health Organization, Lyon, France.
ORCID: 0000-0003-2237-0128

Stephanie J Weinstein (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Lynne R Wilkens (LR)

University of Hawaii Cancer Center, Honolulu, Hawaii, USA.

Bu B Yeap (BB)

Medical School, University of Western Australia, Perth, Western Australia, Australia.
Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia.

Naomi E Allen (NE)

Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
UK Biobank Ltd, Stockport, UK.

Timothy J Key (TJ)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Ruth C Travis (RC)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Circulating free testosterone and risk of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Circulating free testosterone and risk of...
questionsmedicales.fr › Techniques d'investigation › Analyse de randomisation mendélienne › Circulating free testosterone and risk of...
questionsmedicales.fr › Tissus › Glandes exocrines › Prostate › Circulating free testosterone and risk of...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Circulating free testosterone and risk of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Circulating free testosterone and risk of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › bêta-Globulines › Globuline de liaison aux hormones sexuelles › Circulating free testosterone and risk of...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › Testostérone › Circulating free testosterone and risk of...