Update on Exosomes in Aesthetics.
Journal
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
ISSN: 1524-4725
Titre abrégé: Dermatol Surg
Pays: United States
ID NLM: 9504371
Informations de publication
Date de publication:
01 08 2022
01 08 2022
Historique:
pubmed:
18
5
2022
medline:
5
8
2022
entrez:
17
5
2022
Statut:
ppublish
Résumé
In dermatology, exosomes have been leveraged given their roles in wound healing, cell migration, extracellular matrix reconstruction, and angiogenesis. The purpose of this article is to review the literature investigating the use of exosomes in skin rejuvenation and hair regeneration. The PubMed database was searched for studies published through October 2021. Early preclinical studies in aesthetics have demonstrated promising effects of exosomes on skin rejuvenation and hair growth in in vitro and murine models. Despite this, only 1 clinical study has been published to date, and there are no FDA-approved products on the market. Variation in purification techniques and practical issues surrounding isolation, storage, scalability, and reproducibility of an exosome product represent ongoing hindrances to the movement of exosomes into the clinical sphere.
Sections du résumé
BACKGROUND
In dermatology, exosomes have been leveraged given their roles in wound healing, cell migration, extracellular matrix reconstruction, and angiogenesis.
OBJECTIVE
The purpose of this article is to review the literature investigating the use of exosomes in skin rejuvenation and hair regeneration.
MATERIALS AND METHODS
The PubMed database was searched for studies published through October 2021.
RESULTS
Early preclinical studies in aesthetics have demonstrated promising effects of exosomes on skin rejuvenation and hair growth in in vitro and murine models. Despite this, only 1 clinical study has been published to date, and there are no FDA-approved products on the market.
CONCLUSION
Variation in purification techniques and practical issues surrounding isolation, storage, scalability, and reproducibility of an exosome product represent ongoing hindrances to the movement of exosomes into the clinical sphere.
Identifiants
pubmed: 35580250
doi: 10.1097/DSS.0000000000003487
pii: 00042728-202208000-00012
doi:
Types de publication
Journal Article
Review
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
862-865Commentaires et corrections
Type : CommentOn
Informations de copyright
Copyright © 2022 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
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