The Behavioral Phenotype of 7q11.23 Duplication Syndrome Includes Risk for Oppositional Behavior and Aggression.
Journal
Journal of developmental and behavioral pediatrics : JDBP
ISSN: 1536-7312
Titre abrégé: J Dev Behav Pediatr
Pays: United States
ID NLM: 8006933
Informations de publication
Date de publication:
01 08 2022
01 08 2022
Historique:
received:
27
04
2021
accepted:
03
01
2022
pubmed:
18
5
2022
medline:
28
7
2022
entrez:
17
5
2022
Statut:
ppublish
Résumé
7q11.23 duplication syndrome (Dup7) is a genetic disorder with a variable phenotype associated with cognitive and behavioral characteristics including a high incidence of expressive language difficulties, social anxiety, and oppositional or disruptive behavior. Correlates of aggression and oppositionality were examined. Participants were 63 children with genetically confirmed Dup7 between the ages of 4 and 17 years. A multimethod, multi-informant approach was used to assess aggression and oppositional behavior, and the contributions of cognitive functioning, expressive language, autism spectrum, social anxiety, and hyperactivity/impulsivity (H/I) symptomatology were considered. Elevated levels of aggression and oppositional behavior were found. Cognitive functioning, expressive language, and autism spectrum disorder symptomatology were not significantly related to parent ratings of aggression, although young children who had language and nonverbal cognitive delays were most likely to demonstrate examiner-observed aggression. Social anxiety and H/I symptomatology were related to defiant/aggressive and oppositional behavior. Genes in the 7q11.23 region duplicated in Dup7, in transaction with the environment, may contribute to aggressive and oppositional behavior.
Identifiants
pubmed: 35580312
doi: 10.1097/DBP.0000000000001068
pii: 00004703-202208000-00015
pmc: PMC9329151
mid: NIHMS1770230
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e390-e398Subventions
Organisme : NINDS NIH HHS
ID : R01 NS035102
Pays : United States
Informations de copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Velleman SL, Mervis CB. Children with 7q11.23 duplication syndrome: speech, language, cognitive, and behavioral characteristics and their implications for intervention. Perspect Lang Learn Educ. 2011;18:108–116.
Morris CA, Mervis CB, Paciorkowski AP, et al. 23 Duplication syndrome: physical characteristics and natural history. Am J Med Genet A. 1120;167:2916–2935.
Mervis CB, Klein-Tasman BP, Huffman MJ, et al. Children with 7q11.23 duplication syndrome: psychological characteristics. Am J Med Genet A. 2015;167:1436–1450.
Curtis PR, Frey JR, Watson CD, et al. Language disorders and problem behaviors: a meta-analysis. Pediatrics. 2018;142:e20173551.
Emerson E. Prevalence of psychiatric disorders in children and adolescents with and without intellectual disability. J Intellect Disabil Res. 2003;47(pt 1):51–58.
Holden B, Gitlesen JP. A total population study of challenging behaviour in the county of Hedmark, Norway: prevalence, and risk markers. Res Dev Disabil. 2006;27:456–465.
Ando H, Yoshimura I. Speech skill levels and prevalence of maladaptive behaviors in autistic and mentally retarded children: a statistical study. Child Psychiatry Hum Dev. 1979;10:85–90.
Kanne SM, Mazurek MO. Aggression in children and adolescents with ASD: prevalence and risk factors. J Autism Dev Disord. 2011;41:926–937.
Connor DF, Steeber J, McBurnett K. A review of attention-deficit/hyperactivity disorder complicated by symptoms of oppositional defiant disorder or conduct disorder. J Dev Behav Pediatr. 2010;31:427–440.
Dugré JR, Potvin S. Developmental multi-trajectory of irritability, anxiety, and hyperactivity as psychological markers of heterogeneity in childhood aggression. Psychol Med. 2020;5:1–10.
Beidel D, Turner S. Shy Children, Phobic Adults: Nature and Treatment of Social Anxiety Disorder. Washington, DC: American Psychological Association. 2007.
Dugré JR, Dumais A, Dellazizzo L, et al. Developmental joint trajectories of anxiety-depressive trait and trait-aggression: implications for co-occurrence of internalizing and externalizing problems. Psychol Med. 2020;50:1338–1347.
Berg JS, Brunetti-Pierri N, Peters SU, et al. Speech delay and autism spectrum behaviors are frequently associated with duplication of the 7q11.23 Williams-Beuren syndrome region. Genet Med. 2007;9:427–441.
Dixit A, McKee S, Mansour S, et al. 7q11.23 Microduplication: a recognizable phenotype. Clin Genet. 2013;83:155–161.
Dentici ML, Bergonzini P, Scibelli F, et al. 23 microduplication syndrome: clinical and neurobehavioral profiling. Brain Sci. 1120;10:839.
Klein-Tasman BP, Mervis CB. Autism spectrum symptomatology among children with duplication 7q11.23 syndrome. J Autism Dev Disord. 2018;48:1982–1994.
Lord C, Rutter M, Le Couteur A. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord. 1994;24:659–685.
Lord C, Rutter M, DiLavore PC, et al. Autism Diagnostic Observation Schedule. 2nd ed. Torrance, CA: Western Psychological Services; 2012.
Elliott CD. Differential Ability Scales. 2nd ed. San Antonio, TX: Psychological Corporation; 2007.
Secord W, Wiig E, Semel EM. CELF Preschool 2: Clinical Evaluation of Language Fundaments Preschool 2. San Antonio, TX: Pearson/PsychCorp; 2004.
Semel E, Wiig E, Secord WA. Clinical Evaluation of Language Fundamentals (CELF-4). 4th ed. Toronto, Canada: Peason/PsychCorp; 2003.
Silverman WK, Albano AM. The Anxiety Disorders Interview Schedule for DSM-IV: Parent Interview Schedule. Graywind, NY: Graywind Publication; 1996.
Conners CK. Conners Early Childhood: Manual. 3rd ed. Toronto, Canada: Multi-Health Systems Incorporated; 2009.
Conners CK. Conners Comprehensive Behavior Rating Scale. Toronto, Canada: Multi-Health Systems; 2008.
Hartley SL, Sikora DM, McCoy R. Prevalence and risk factors of maladaptive behaviour in young children with Autistic Disorder. J Intellect Disabil Res. 2008;52:819–829.
Matson JL, Rivet TT. Characteristics of challenging behaviours in adults with autistic disorder, PDD-NOS, and intellectual disability. J Intellect Dev Disabil. 2008;33:323–329.
Fitzpatrick SE, Srivorakiat L, Wink LK, et al. Aggression in autism spectrum disorder: presentation and treatment options. Neuropsychiatr Dis Treat. 2016;12:1525–1538.
Card NA, Stucky BD, Sawalani GM, et al. Direct and indirect aggression during childhood and adolescence: a meta-analytic review of gender differences, intercorrelations, and relations to maladjustment. Child Dev. 2008;79:1185–1229.
Hinshaw SP. On the distinction between attentional deficits/hyperactivity and conduct problems/aggression in child psychopathology. Psychol Bull. 1987;101:443–463.
Martel MM. Research review: a new perspective on attention-deficit/hyperactivity disorder: emotion dysregulation and trait models. J Child Psychol Psychiatry. 2009;50:1042–1051.
NICHD Early Child Care Research Network. Trajectories of physical aggression from toddlerhood to middle childhood: predictors, correlates, and outcomes. Monogr Soc Res Child Dev. 2004;69:7.
Pugliese CE, White BA, White SW, et al. Social anxiety predicts aggression in children with ASD: clinical comparisons with socially anxious and oppositional youth. J Autism Dev Disord. 2013;43:1205–1213.
White SW, Kreiser NL, Pugliese C, et al. Social anxiety mediates the effect of autism spectrum disorder characteristics on hostility in young adults. Autism. 2012;16:453–464.
Vitaro F, Brendgen M, Tremblay RE. Reactively and proactively aggressive children: antecedent and subsequent characteristics. J Child Psychol Psychiatry. 2002;43:495–505.
Kunimatsu MM, Marsee MA. Examining the presence of anxiety in aggressive individuals: the illuminating role of fight-or-flight mechanisms. Child Youth Care Forum. 2012;41:247–258.
Berkowitz G. UCLA study on friendship among women: an alternative to fight or flight. Curr Psychiatry Rep. 2002;4:441–448.
Leyfer OT, Woodruff-Borden J, Klein-Tasman BP, et al. Prevalence of psychiatric disorders in 4 to 16-year-olds with Williams syndrome. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:615–622.
Broidy LM, Nagin DS, Tremblay RE, et al. Developmental trajectories of childhood disruptive behaviors and adolescent delinquency: a six-site, cross-national study. Dev Psychol. 2003;39:222–245.