A
adenosine
immunotherapy
lymphocyte activation
lymphocytes, tumor-infiltrating
Journal
Journal for immunotherapy of cancer
ISSN: 2051-1426
Titre abrégé: J Immunother Cancer
Pays: England
ID NLM: 101620585
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
accepted:
26
04
2022
entrez:
17
5
2022
pubmed:
18
5
2022
medline:
21
5
2022
Statut:
ppublish
Résumé
Adenosine is a metabolite that suppresses antitumor immune response of T and NK cells via extracellular binding to the two subtypes of adenosine-2 receptors, A We report the synthesis and functional evaluation of five potent A We provide data for six novel small molecules: five A Our results demonstrate that A
Sections du résumé
BACKGROUND
Adenosine is a metabolite that suppresses antitumor immune response of T and NK cells via extracellular binding to the two subtypes of adenosine-2 receptors, A
METHODS
We report the synthesis and functional evaluation of five potent A
RESULTS
We provide data for six novel small molecules: five A
CONCLUSIONS
Our results demonstrate that A
Identifiants
pubmed: 35580926
pii: jitc-2022-004592
doi: 10.1136/jitc-2022-004592
pmc: PMC9115112
pii:
doi:
Substances chimiques
Purinergic P1 Receptor Antagonists
0
Receptor, Adenosine A2B
0
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared
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