Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells.
calcium-sensing receptor
hypercalcemia
mineral metabolism
transgenic mouse
vascular calcification
vascular smooth muscle
Journal
Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
30
04
2021
accepted:
07
03
2022
pubmed:
18
5
2022
medline:
6
7
2022
entrez:
17
5
2022
Statut:
ppublish
Résumé
Impaired mineral ion metabolism is a hallmark of CKD-metabolic bone disorder. It can lead to pathologic vascular calcification and is associated with an increased risk of cardiovascular mortality. Loss of calcium-sensing receptor (CaSR) expression in vascular smooth muscle cells exacerbates vascular calcification To determine the role of the CaSR in vascular calcification, we characterized mice with targeted Vascular smooth muscle cells cultured from the knockout (KO) mice calcified more readily than those from control (wild-type) mice These results suggest that, in addition to CaSR's established role in the parathyroid-kidney-bone axis, expression of CaSR in vascular smooth muscle cells directly contributes to total body mineral ion homeostasis.
Sections du résumé
BACKGROUND
Impaired mineral ion metabolism is a hallmark of CKD-metabolic bone disorder. It can lead to pathologic vascular calcification and is associated with an increased risk of cardiovascular mortality. Loss of calcium-sensing receptor (CaSR) expression in vascular smooth muscle cells exacerbates vascular calcification
METHODS
To determine the role of the CaSR in vascular calcification, we characterized mice with targeted
RESULTS
Vascular smooth muscle cells cultured from the knockout (KO) mice calcified more readily than those from control (wild-type) mice
CONCLUSIONS
These results suggest that, in addition to CaSR's established role in the parathyroid-kidney-bone axis, expression of CaSR in vascular smooth muscle cells directly contributes to total body mineral ion homeostasis.
Identifiants
pubmed: 35581010
pii: 00001751-202207000-00018
doi: 10.1681/ASN.2021040585
pmc: PMC9257819
doi:
Substances chimiques
Minerals
0
Receptors, Calcium-Sensing
0
Fibroblast Growth Factors
62031-54-3
Klotho Proteins
EC 3.2.1.31
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1323-1340Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR066262
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG070721
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121656
Pays : United States
Organisme : Austrian Science Fund FWF
ID : P 29948
Pays : Austria
Organisme : NIDDK NIH HHS
ID : R01 DK122259
Pays : United States
Organisme : BLRD VA
ID : IK6 BX004835
Pays : United States
Organisme : BLRD VA
ID : I01 BX005851
Pays : United States
Informations de copyright
Copyright © 2022 by the American Society of Nephrology.
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