Study of the volatilization rules of volatile oil and the sustained-release effect of volatile oil solidified by porous starch.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 05 2022
17 05 2022
Historique:
received:
05
11
2020
accepted:
27
04
2022
entrez:
17
5
2022
pubmed:
18
5
2022
medline:
21
5
2022
Statut:
epublish
Résumé
Volatile oil from traditional Chinese medicine has various biological activities and has pharmacological activities in the central nervous system, digestive system, cardiovascular system, respiratory system, etc. These oils are widely used in clinical practice. However, the development of their clinical applications is restricted due to the disadvantages of volatile oils, such as high stimulation, high volatility and poor stability. To improve the stability of a volatile oil in the preparation process, its volatilization and stable release must be controlled. In this paper, porous starch was used as a solid carrier material, and liquid volatile oil was solidified by physical adsorption. GC-MS was used to determine the chemical constituents of the volatile oil, solidified powder and tablets, and the volatilization rules of 34 chemical constituents were analysed statistically. The solidified volatile oil/porous starch powder was characterized by XRD, TGA and DSC, and the VOCs of the volatile oil before and after solidification were analysed by portable GC-MS. Finally, the stable release of the volatile oil could be optimized by changing the porous starch ratio in the formulation. Volatilization was shown to be closely related to the peak retention time and chemical composition, which was consistent with the theory of flavour. The physical properties and chemical composition of the volatile oil did not change after curing, indicating that the adsorption of the volatile oil by porous starch was physical adsorption. In this paper, the porous starch-solidified volatile oil had a slow-release effect, and the production process is simple, easy to operate, and has high application value.
Identifiants
pubmed: 35581209
doi: 10.1038/s41598-022-11692-w
pii: 10.1038/s41598-022-11692-w
pmc: PMC9114342
doi:
Substances chimiques
Delayed-Action Preparations
0
Oils, Volatile
0
Powders
0
Starch
9005-25-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8153Informations de copyright
© 2022. The Author(s).
Références
Biomed Res Int. 2019 Mar 11;2019:5640173
pubmed: 31275977
Foods. 2019 Sep 07;8(9):
pubmed: 31500259
J Integr Med. 2014 Mar;12(2):115-20
pubmed: 24666677
J Ethnopharmacol. 2021 Jan 30;265:113326
pubmed: 32877718
BMC Complement Altern Med. 2019 Nov 11;19(1):306
pubmed: 31711477
Evid Based Complement Alternat Med. 2019 Jun 4;2019:9241403
pubmed: 31275424
Food Chem. 2017 Mar 1;218:365-371
pubmed: 27719922
Food Chem. 2020 Nov 30;331:127201
pubmed: 32562976
Food Chem. 2020 May 30;313:126095
pubmed: 31923873
Nat Prod Res. 2020 Sep;34(18):2621-2625
pubmed: 30908095
Cell Biol Int. 2019 Jan;43(1):2-11
pubmed: 30080277
Food Chem Toxicol. 2019 Nov;133:110802
pubmed: 31493462
Pharmaceutics. 2018 Oct 01;10(4):
pubmed: 30275390
Ultrason Sonochem. 2020 Jun;64:104997
pubmed: 32058914
Sci Rep. 2020 Feb 18;10(1):2812
pubmed: 32071359
Mini Rev Med Chem. 2019;19(17):1459-1471
pubmed: 31218957
J Agric Food Chem. 2013 Jul 3;61(26):6293-8
pubmed: 23738884
J Agric Food Chem. 2019 Nov 20;67(46):12875-12884
pubmed: 31644278
Biology (Basel). 2020 May 30;9(6):
pubmed: 32486128
Comb Chem High Throughput Screen. 2020;23(5):419-432
pubmed: 32233997
J Agric Food Chem. 2018 Oct 17;66(41):10799-10807
pubmed: 30256627
Front Pharmacol. 2019 May 09;10:472
pubmed: 31143116